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Epidemiology of childhood tuberculosis in Switzerland between 1996 and 2011

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Abstract

Approximately 9 million cases of tuberculosis (TB) are reported annually and half a million occur in children <15 years of age. Globally, TB notifications in children have been neglected for decades although childhood TB may represent a sentinel for ongoing transmission. Data included in this study were collected from the TB database of the Swiss Federal Office of Public Health, which includes culture-confirmed TB and/or cases treated with ≥3 anti-mycobacterial drugs. Data from all children <15 years of age reported between 1996 and 2011 were analyzed. A total of 320 cases of TB (166 cultures confirmed, 5 confirmed by nucleic acid amplification, 149 other than definite cases) were reported with an overall incidence rate of 1.6 per 100,000 children (range 1.2–2.2). A total of 154 (48 %) children were younger than 5 years of age and 141 (44 %) were born in Switzerland. Children below 5 years of age were more likely to be Swiss-born compared to children aged 10 to 14 years (74 % versus 26 %). When analyzing the country of origin, only 55 children (17 %) were of Swiss origin. Of all children with foreign origin, 117 (47 %) were from a country within the WHO European Region. In 288 (90 %) of all notified cases, the site of disease was the lung. Mycobacterial culture was positive in 166 cases (51.9 %) with 1.8 % multi-drug-resistance. The overall incidence of childhood TB disease reported in Switzerland remained stable over a 16-year period with a remarkable high rate of very young patients of foreign origin. Only half of the reported cases were culture confirmed, highlighting the need for better diagnostic tests in childhood TB.

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References

  1. Abubakar I, Laundy MT, French CE, Shingadia D (2008) Epidemiology and treatment outcome of childhood tuberculosis in England and Wales: 1999–2006. Arch Dis Child 93:1017–1021

    Article  CAS  PubMed  Google Scholar 

  2. Basu Roy R, Sotgiu G, Altet-Gomez N, Tsolia M, Ruga E, Velizarova S, Kampmann B (2012) Identifying predictors of interferon-gamma release assay results in pediatric latent tuberculosis: a protective role of bacillus Calmette-Guerin?: a pTB-NET collaborative study. Am J Respir Crit Care Med 186:378–384

    Article  PubMed  Google Scholar 

  3. Brandli O, Zellweger JP (2011) Tuberculosis in Switzerland. Ther Umsch Rev Therapeutique 68:365–368

    Article  Google Scholar 

  4. Bundesamt für Gesundheit (2011) Tuberkulose in der Schweiz 2005–2009. Bull BAG 10:205–213

    Google Scholar 

  5. Bundesamt für Gesundheit (2013) Tuberkulose in der Schweiz 2005 bis 2011. Bull BAG 21:343–346

  6. Bundesamt für Statistik (2011) Bevölkerung. http://www.bfs.admin.ch/. Accessed 18 Aug 2013

  7. Connell T, Tebruegge M, Ritz N, Curtis N (2009) Interferon-gamma release assays for the diagnosis of tuberculosis. Pediatr Infect Dis J 28:758–759

    Article  PubMed  Google Scholar 

  8. Connell TG, Tebruegge M, Ritz N, Bryant P, Curtis N (2011) The potential danger of a solely interferon-gamma release assay-based approach to testing for latent Mycobacterium tuberculosis infection in children. Thorax 66:263–264, author reply 265

    Article  CAS  PubMed  Google Scholar 

  9. European Centre for Disease Prevention and Control, WHO Regional Office for Europe (2013) Tuberculosis surveillance and monitoring in Europe 2013. Stockholm: European Centre for Disease Prevention and Control

  10. Graham SM (2011) Treatment of paediatric TB: revised WHO guidelines. Paediatr Respir Rev 12:22–26

    Article  PubMed  Google Scholar 

  11. Lungenliga Schweiz, Bundesamt für Gesundheitswesen (2012) Handbuch Tuberkulose. http://www.tbinfo.ch/uploads/media/Handbuch_Tuberkulose_2012_de.pdf. Accessed 18 Aug 2013

  12. Nejat S, Buxbaum C, Eriksson M, Pergert M, Bennet R (2012) Pediatric tuberculosis in Stockholm: a mirror to the world. Pediatr Infect Dis J 31:224–227

    Article  PubMed  Google Scholar 

  13. Nelson LJ, Wells CD (2004) Global epidemiology of childhood tuberculosis. Int J Tuberc Lung Dis 8:636–647

    CAS  PubMed  Google Scholar 

  14. Rieder HL, Watson JM, Raviglione MC, Forssbohm M, Migliori GB, Schwoebel V, Leitch AG, Zellweger JP (1996) Surveillance of tuberculosis in Europe. Working Group of the World Health Organization (WHO) and the European Region of the International Union Against Tuberculosis and Lung Disease (IUATLD) for uniform reporting on tuberculosis cases. Eur Respir J 9:1097–1104

    Google Scholar 

  15. Ritz N, Connell TG, Curtis N (2008) To BCG or not to BCG? Preventing travel-associated tuberculosis in children. Vaccine 26:5905–5910

    Article  PubMed  Google Scholar 

  16. Ruwende JE, Sanchez-Padilla E, Maguire H, Carless J, Mandal S, Shingadia D (2011) Recent trends in tuberculosis in children in London. J Public Health (Oxf) 33:175–181

    Article  CAS  Google Scholar 

  17. Sandgren A, Hollo V, Quinten C, Manissero D (2011) Childhood tuberculosis in the European Union/European Economic Area, 2000 to 2009. Euro surveill 16(12):pii=19825

    Google Scholar 

  18. Schneeberger Geisler S, Helbling P, Zellweger JP, Altpeter ES (2010) Screening for tuberculosis in asylum seekers: comparison of chest radiography with an interview-based system. Int J Tuberc Lung Dis 14:1388–1394

    Google Scholar 

  19. Seddon JA, Godfrey-Faussett P, Hesseling AC, Gie RP, Beyers N, Schaaf HS (2012) Management of children exposed to multidrug-resistant Mycobacterium tuberculosis. Lancet Infect Dis 12:469–479

    Article  PubMed  Google Scholar 

  20. Tebruegge M, Salo E, Ritz N, Kampmann B, On Behalf Of The Paediatric Tuberculosis Network European Trialsgroup P (2013) Inclusion of latent tuberculosis infection as a separate entity into the international classification of diseases. Thorax 68:588

    Article  PubMed  Google Scholar 

  21. The Sentinel Project for Pediatric Drug-Resistant Tuberculosis (2012) Management of drug-resistant tuberculosis in children: a field guide. http://sentinelproject.files.wordpress.com/2012/11/sentinel_project_field_guide_2012.pdf. Accessed 20 Oct 2013

  22. Winston CA, Menzies HJ (2012) Pediatric and adolescent tuberculosis in the United States, 2008–2010. Pediatrics 130:e1425–e1432

    Article  PubMed  Google Scholar 

  23. World Health Organization (2012) Global tuberculosis report 2012. http://www.who.int/tb/publications/global_report/en/. Accessed 18 Aug 2013

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Acknowledgments

NR is supported by a career advancement grant from the University of Basel and the Rozalia foundation.

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None of the authors declare a conflict of interest.

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Correspondence to Nicole Ritz.

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Oesch Nemeth, G., Nemeth, J., Altpeter, E. et al. Epidemiology of childhood tuberculosis in Switzerland between 1996 and 2011. Eur J Pediatr 173, 457–462 (2014). https://doi.org/10.1007/s00431-013-2196-z

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  • DOI: https://doi.org/10.1007/s00431-013-2196-z

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