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Mebendazole in the treatment of Hymenolepis nana infections in the captive ring-tailed lemur (Lemur catta), China

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Abstract

The present study was conducted to evaluate the effectiveness of mebendazole in the treatment of Hymenolepis nana infection in ring-tailed lemurs (Lemur catta). Ten (L. catta) from the Chengdu Zoological Garden in China, which were naturally infected with H. nana, were treated with mebendazole (10 mg/kg for 5 days). A posttreatment fecal examination was conducted 10 and 20 days after the start of treatment. All treatments resulted in a decrease in the number of eggs per gram in the posttreatment sample compared with the pretreatment sample. Reduction of mean egg count was 97.6% and 100% on days 10 and 20, respectively. The results indicated that mebendazole has marked efficacy against H. nana infections in L. catta.

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References

  • Ben-Ismail R (1984) Evaluation of the activity of mebendazole in taeniasis caused by Hymenolepis nana in Tunisia. Bull Soc Pathol Exot Filiales 77:363–368

    PubMed  CAS  Google Scholar 

  • Brack M, Rietschel W (1986) Ivermectin for the control of Strongyloides fuelleborni in rhesus monkeys. Kleintierpraxis 31:29

    Google Scholar 

  • Bernacky BJ, Gibson SV, Keeling ME, Abee CR (2005) Nonhuman primates. In: Fox JG, Anderson LC, Loew FM, Quimby FW (eds) Laboratory animal medicine, 2nd edn. Academic, New York, pp 675–791

  • Cheng XB, Wu GL, Sun X (2002) Modern parasitology. People's Military Medical Press, Beijing, pp 781–786 (in Chinese)

    Google Scholar 

  • Coles GC, Bauer C, Borgsteede FHM, Geerts S, Klei TR, Taylor MA, Waller PJ (1992) World Association for the Advancement of Veterinary Parasitology (WAAVP) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol 44:35–44

    Article  PubMed  CAS  Google Scholar 

  • Dufour JP, Cogswell FB, Phillippi-Falkenstein KM, Bohm RP (2006) Comparison of efficacy of moxidectin and ivermectin in the treatment of Strongyloides fulleborni infection in rhesus macaques. J Med Primatol 35:172–176

    Article  PubMed  CAS  Google Scholar 

  • El-Ridi AM, El-Gamal RL, Farghaly AM, Nada SM (1989) Effect of some anthelmintics on Hymenolepis nana in albino mice. J Egypt Soc Parasitol 19:477–482

    PubMed  CAS  Google Scholar 

  • Hamlen HJ, Lawrence JM (1994) Giardiasis in laboratory housed squirrel monkeys: a retrospective study. Lab Anim Sci 44:235–239

    PubMed  CAS  Google Scholar 

  • Mario TP, Jeanette EP (2005) Modeling parasitic diseases in nonhuman primates: malaria, chagas' disease, and filariasis. In: Sonia WC (eds) The laboratory primate, USA, pp 91–99

  • Karr SL, Henrickson RV, Else JG (1980) A survey for intestinal helminths in recently wild-caught Macaca mulatta and results of treatment with mebendazole and thiabendazole. J Med Primatol 9:200–204

    PubMed  Google Scholar 

  • Khalil HM, El SS, Sarwat MA, Fawzy AF, El SA (1991) Recent study of Hymenolepis nana infection in Egyptian children. J Egypt Soc Parasitol 21:293–300

    PubMed  CAS  Google Scholar 

  • Levi MH, Raucher BG, Teicher E, Sheehan DJ, Mckitrick JC (1987) Hymenolepis diminuta: one of three enteric pathogens isolated from a child. Diagn Microbiol Infect Dis 7:255–259

    Article  PubMed  CAS  Google Scholar 

  • Liu J, Wang BN, Fan WH, Zhou HF (2009) Infection and analysis of one case with Hymenolepis nana. Acta Parasitologica et Medica 16:55–56

    Google Scholar 

  • Maki J, Yanagisawa T (1985) Anthelmintic effects of bithionol, paromomycin sulphate, flubendazole and mebendazole on mature and immature Hymenolepis nana in mice. J Helminthol 59:211–216

    Article  PubMed  CAS  Google Scholar 

  • Miller RA, Bronsdon MA, Kuller L, Morton WR (1990) Clinical and parasitologic aspects of cryptosporidiosis in nonhuman primates. Lab Anim Sci 40:42–46

    PubMed  CAS  Google Scholar 

  • Novak M, Evans WS (1981) Mebendazole and the development of Hymenolepis nana in mice. Int J Parasitol 11:277–280

    Article  PubMed  CAS  Google Scholar 

  • Panaitescu D, Capraru T, Bugarin V (1995) Study of the incidence of intestinal and systemic parasitoses in a group of children with handicaps. Roum Arch Microbiol Immunol 54:65–74

    PubMed  CAS  Google Scholar 

  • Shen LJ, Li W, Qian TJ, Luo ZY (2002) Investigation on Hymenolepis nana infection in wild small mammals in Xiaguan, Dali, Yunnan. Endemic Diseases Bull 17:23–25

    Google Scholar 

  • Sirivichayakul C, Radomyos P, Praevanit R, Pojjaroen-Anant C, Wisetsing P (2000) Hymenolepis nana infection in Thai children. J Med Assoc Thai 83:1035–1038

    PubMed  CAS  Google Scholar 

  • Wang HZ, Zhang LL (2006) One case of Taenia nana infection. J Pathogen Biol 1:383–390

    Google Scholar 

  • Wang T, Yang GY, Yan HJ, Wang S, Bian Y, Chen AC, Bi FJ (2008) Comparison of efficacy of selamectin, ivermectin and mebendazole for the control of gastrointestinal nematodes in rhesus macaques, China. Vet Parasitol 153:121–125

    Article  PubMed  CAS  Google Scholar 

  • William H, Deaderick MD (1906) Hymenolepis nana and hymenolepis diminuta with report of cases. J Am Med Assoc XLVII:2087–2090

    Article  Google Scholar 

  • Xu LQ, Yu SH, Xu SH (2000) Distribution and hazard of human parasites in China. People's Military Medical Press, Beijing, pp 216–217 (in Chinese)

    Google Scholar 

Download references

Acknowledgments

This project was supported by the Program for Changjiang Scholars and Innovative Research Team in University (IRT0848) and Research Fund for the Chengdu Research of Giant Panda Breeding (project no. CPF-08005). The authors thank Ying-wang Wang, Bing Peng, Yan Fu, Yu-xiang Fei, and Xing-ming Yu for their kind help and thorough review of the manuscript.

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Correspondence to Guang-you Yang.

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Bo Li and Bo Zhao equally contributed to this work.

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Li, B., Zhao, B., Yang, Gy. et al. Mebendazole in the treatment of Hymenolepis nana infections in the captive ring-tailed lemur (Lemur catta), China. Parasitol Res 111, 935–937 (2012). https://doi.org/10.1007/s00436-012-2838-5

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  • DOI: https://doi.org/10.1007/s00436-012-2838-5

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