Abstract
Malaria is a parasitic disease that remains a global health issue, responsible for a significant death and morbidity toll. Various factors have impacted the use and delayed the development of antimalarial therapies, such as the associated financial cost and parasitic resistance. In order to discover new drugs and validate parasitic targets, a powerful omics tool, metabolomics, emerged as a reliable approach. However, as a fairly recent method in malaria, new findings are timely and original practices emerge frequently. This review aims to discuss recent research towards the development of new metabolomic methods in the context of uncovering antiplasmodial mechanisms of action in vitro and to point out innovative metabolic pathways that can revitalize the antimalarial pipeline.
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References
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This work was supported by the Belgian National Fund for Scientific Research (FNRS, grant PDR T.0092.20).
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Allison Ledoux, Pascal De Tullio, Joëlle Quetin-Leclercq, and Michel Frédérich had the idea for the review. Lúcia Mamede and Fanta Fall did the bibliographic search. Lúcia Mamede wrote the main manuscript text and prepared the figures. Fanta Fall, Matthieu Schoumacher, Allison Ledoux, Pascal De Tullio, Joëlle Quetin-Leclercq, and Michel Frédérich read the manuscript and participated in the preparation of the final version of the manuscript. All authors reviewed and approved the final manuscript.
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Mamede, L., Fall, F., Schoumacher, M. et al. Recent metabolomic developments for antimalarial drug discovery. Parasitol Res 121, 3351–3380 (2022). https://doi.org/10.1007/s00436-022-07673-7
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DOI: https://doi.org/10.1007/s00436-022-07673-7