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On the utility of data from the International HapMap Project for Australian association studies

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Abstract

We compare patterns of linkage disequilibrium (LD) for 633 SNPs in two regions between samples collected in two Australian states and HapMap samples collected from Utah residents of Northern and Western (NW) European ancestry (CEU). Patterns of LD in the Australian and HapMap samples are similar, and tag SNPs chosen using HapMap genotypes perform almost as well on Australian samples as tags chosen using Australian genotypes.

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Authors and Affiliations

  1. Division of Genetics and Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 3050, Parkville, Victoria, Australia

    Jim Stankovich, Rachel B. Tan, Stewart J. Huxtable, Terence P. Speed, Melanie Bahlo & Simon J. Foote

  2. GlaxoSmithKline R&D, Harlow, UK

    Charles J. Cox, Douglas S. Montgomery, Margaret G. Ehm & Allen D. Roses

  3. The Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia

    Justin P. Rubio, Laura Johnson, Helmut Butzkueven & Trevor J. Kilpatrick

  4. Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia

    Simon J. Foote

Authors
  1. Jim Stankovich
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  2. Charles J. Cox
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  3. Rachel B. Tan
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  4. Douglas S. Montgomery
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  5. Stewart J. Huxtable
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  6. Justin P. Rubio
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  7. Margaret G. Ehm
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  8. Laura Johnson
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  9. Helmut Butzkueven
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  10. Trevor J. Kilpatrick
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  11. Terence P. Speed
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  12. Allen D. Roses
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  13. Melanie Bahlo
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  14. Simon J. Foote
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Corresponding author

Correspondence to Jim Stankovich.

Additional information

Electronic database information: URLs for the data in this article are as follows. Haploview Software, including Tagger program: http://www.broad.mit.edu/mpg/haploview; The International Hapmap Project: http://www.hapmap.org; Australian Bureau of Statistics, for population ancestry information: http://www.abs.gov.au

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Stankovich, J., Cox, C., Tan, R. et al. On the utility of data from the International HapMap Project for Australian association studies. Hum Genet 119, 220–222 (2006). https://doi.org/10.1007/s00439-005-0120-y

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  • DOI: https://doi.org/10.1007/s00439-005-0120-y

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