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Prospective associations of cardiovascular disease with physical performance and disability

A longitudinal cohort study in the Osteoarthritis Initiative

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Summary

Background

Literature regarding cardiovascular disease (CVD) and incident physical performance limitations and disability in older people is equivocal.

Aims

This study aimed to investigate whether CVD is longitudinally associated with incident physical performance limitations and disability in a large population-based sample.

Methods

This was an 8‑year prospective study using data collected as part of the Osteoarthritis Initiative. Participants were community-dwelling adults with knee osteoarthritis or at high risk for this condition. Diagnosed CVD was self-reported. Physical performance was assessed with measures of chair stand time and gait speed, whereas disability was assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Longitudinal associations between CVD and changes in physical performance tests (chair stand time and gait speed) and disability score were analyzed using generalized linear models with repeated measurements.

Results

The analyzed sample comprised 4796 adults (mean age 61.2 years, 58.5% female), of whom 313 people (6.5%) reported CVD at baseline. During 8 years of follow-up, after adjustment for 11 potential confounders measured at baseline, those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD (p = 0.006).

Conclusion

In a cohort of middle-aged and older adults with knee osteoarthritis or at high risk for this condition those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD; however, CVD was not significantly associated with an increased incidence of poor gait speed and disability over 8 years of follow-up. Importantly, no associations were observed when utilizing propensity score matching.

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Author information

Authors and Affiliations

  1. Aging Branch, Neuroscience Institute, National Research Council, Padova, Italy

    Nicola Veronese & Stefania Maggi

  2. Department of Geriatric Care, Orthogeriatrics and Rehabilitation, E. O. Galliera Hospital, National Relevance & High Specialization Hospital, Genoa, Italy

    Nicola Veronese & Stefania Maggi

  3. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, De Crespigny Park, Box, SE5 8AF, London, UK

    Brendon Stubbs

  4. Department of Behavioural Science and Health, University College London, London, UK

    Sarah E Jackson

  5. Research and Development Unit, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Parc Sanitari Sant Joan de Déu, Carrer Del Dr. Antoni Pujadas 42, Barcelona, Spain

    Ai Koyanagi

  6. Primary Care Department, Azienda ULSS (Unità Locale Socio Sanitaria) 3 “Serenissima”, 30031, Dolo, Mirano District, Italy

    Vania Noventa

  7. Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria) 3 “Serenissima”, 30031, Dolo, Mirano District, Italy

    Francesco Bolzetta & Alberto Cester

  8. Department of geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey

    Pinar Soysal

  9. Faculty of Sport Sciences, University of Murcia, Murcia, Spain

    Guillermo F. López-Sánchez

  10. Institute of Sport Exercise and Health Sciences, University College London Hospital, London, UK

    Mike Loosemore

  11. Primary Care Department, Azienda USL Toscana Sud Est, 58100, Grosseto, Italy

    Jacopo Demurtas

  12. The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK

    Lee Smith

Authors
  1. Nicola Veronese
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  2. Brendon Stubbs
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  3. Sarah E Jackson
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  4. Ai Koyanagi
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  5. Vania Noventa
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  6. Francesco Bolzetta
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  7. Alberto Cester
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  8. Pinar Soysal
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  9. Stefania Maggi
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  10. Guillermo F. López-Sánchez
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  11. Mike Loosemore
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  12. Jacopo Demurtas
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  13. Lee Smith
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Corresponding author

Correspondence to Lee Smith.

Ethics declarations

Conflict of interest

N. Veronese, B. Stubbs, S.E. Jackson, A. Koyanagi, V. Noventa, F. Bolzetta, A. Cester, P. Soysal, S. Maggi, G.F. López-Sánchez, M. Loosemore, J. Demurtas, and L. Smith declare that they have no competing interests.

Ethical standards

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from all individual participants included in the study.

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Caption Electronic Supplementary Material

508_2019_1567_MOESM1_ESM.docx

Supplementary Table 1. Regression analysis using chair stand time at the last follow-up as outcome. Supplementary Table 2. Regression analysis using walking speed at the last follow-up as outcome. Supplementary Table 3. Regression analysis using disability at the last follow-up as outcome.

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Veronese, N., Stubbs, B., Jackson, S.E. et al. Prospective associations of cardiovascular disease with physical performance and disability. Wien Klin Wochenschr 132, 73–78 (2020). https://doi.org/10.1007/s00508-019-01567-y

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