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Conjugated polymer nanoparticles and their nanohybrids as smart photoluminescent and photoresponsive material for biosensing, imaging, and theranostics

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Abstract

The emergence of conjugated polymers (CPs) has provided a pathway to attain smart multifunctional conjugated polymer nanoparticles (CPNs) with enhanced properties and diverse applications. CPNs based on π-extended CPs exhibit high fluorescence brightness, low cytotoxicity, excellent photostability, reactive oxygen species (ROS) generation ability, high photothermal conversion efficiency (PCE), etc. which endorse them as an excellent theranostic tool. Furthermore, the unique light-harvesting and energy transfer properties of CPNs enables their transformation into smart functional nanohybrids with augmented performance. Owing to such numerous features, simple preparation method and an easy separation process, the CPNs and their hybrids have been constantly rising as a frontrunner in the domain of medicine and much work has been done in the respective research area. This review summarizes the recent progress that has been made in the field of CPNs for biological and biomedical applications with special emphasis on biosensing, imaging, and theranostics. Following an introduction into the field, a first large section provides overview of the conventional as well as recently established synthetic methods for various types of CPNs. Then, the CPNs-based fluorometric assays for biomolecules based on different detection strategies have been described. Later on, examples of CPNs-based probes for imaging, both in vitro and in vivo using cancer cells and animal models have been explored. The next section highlighted the vital theranostic applications of CPNs and corresponding nanohybrids, mainly via imaging-guided photodynamic therapy (PDT), photothermal therapy (PTT) and drug delivery. The last section summarizes the current challenges and gives an outlook on the potential future trends on CPNs as advanced healthcare material.

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Funding

Financial support from National Natural Science Foundation of China (Nos. 21305107, 81701830), the Natural Science Foundation of Shaanxi Province (Nos. 2020JM-066, 2020JQ-019), the Fundamental Research Funds for the Central Universities (Nos. xjh012020001, xjj2017028) and China Postdoctoral Science Foundation (No. 2020M673368) is gratefully acknowledged.

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  1. Xi Chen and Sameer Hussain contributed equally to the work.

Authors and Affiliations

  1. School of Chemistry, Xi’an Jiaotong University, Xi’an, 710049, Shaanxi, China

    Xi Chen, Sameer Hussain, Ansar Abbas, Xuemeng Tian & Ruixia Gao

  2. School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, 710061, Shaanxi, China

    Yi Hao

  3. Department of Chemistry, Government Degree College, Sopore , 193201, Jammu & Kashmir, India

    Akhtar H. Malik

  4. Department of Urology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710004, Shaanxi, China

    Huijia Song

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  1. Xi Chen
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Chen, X., Hussain, S., Abbas, A. et al. Conjugated polymer nanoparticles and their nanohybrids as smart photoluminescent and photoresponsive material for biosensing, imaging, and theranostics. Microchim Acta 189, 83 (2022). https://doi.org/10.1007/s00604-021-05153-w

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