Abstract
Genome-wide association study results have linked ADCK1 genetic variation with paliperidone efficacy in a European cohort. However, the generalizability of this locus to non-European populations is unknown. Han Chinese schizophrenia patients (n = 159) were treated with paliperidone palmitate and symptom severity was assessed over 3 months. Examination of 13 ADCK1 genetic variants revealed two single nucleotide polymorphisms (rs12590199, rs11159291) and one haplotype (rs2364747–rs12590199) associated with paliperidone palmitate response. Future work into ADCK1’s function and its potential interaction with paliperidone is warranted.
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References
Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M, Karczewski KJ, Park J, Hitz BC, Weng S, Cherry JM, Snyder M (2012) Annotation of functional variation in personal genomes using RegulomeDB. Genome Res 22(9):1790–1797. https://doi.org/10.1101/gr.137323.112
Brandl EJ, Kennedy JL, Muller DJ (2014) Pharmacogenetics of antipsychotics. Can J Psychiatry 59(2):76–88. https://doi.org/10.1177/070674371405900203
Consortium GT (2013) The Genotype-tissue expression (GTEx) project. Nat Genet 45(6):580–585. https://doi.org/10.1038/ng.2653
Hough D, Lindenmayer JP, Gopal S, Melkote R, Lim P, Herben V, Yuen E, Eerdekens M (2009) Safety and tolerability of deltoid and gluteal injections of paliperidone palmitate in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 33(6):1022–1031. https://doi.org/10.1016/j.pnpbp.2009.05.014
Kane J, Canas F, Kramer M, Ford L, Gassmann-Mayer C, Lim P, Eerdekens M (2007) Treatment of schizophrenia with paliperidone extended-release tablets: a 6-week placebo-controlled trial. Schizophr Res 90(1–3):147–161. https://doi.org/10.1016/j.schres.2006.09.012
Li Q, Wineinger NE, Fu DJ, Libiger O, Alphs L, Savitz A, Gopal S, Cohen N, Schork NJ (2017) Genome-wide association study of paliperidone efficacy. Pharmacogenet Genom 27(1):7–18. https://doi.org/10.1097/FPC.0000000000000250
Marder SR, Davis JM, Chouinard G (1997) The effects of risperidone on the five dimensions of schizophrenia derived by factor analysis: combined results of the North American trials. J Clin Psychiatry 58(12):538–546
Marder SR, Kramer M, Ford L, Eerdekens E, Lim P, Eerdekens M, Lowy A (2007) Efficacy and safety of paliperidone extended-release tablets: results of a 6-week, randomized, placebo-controlled study. Biol Psychiatry 62(12):1363–1370. https://doi.org/10.1016/j.biopsych.2007.01.017 pii].
Meltzer HY, Bobo WV, Nuamah IF, Lane R, Hough D, Kramer M, Eerdekens M (2008) Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 6-week, placebo-controlled studies. J Clin Psychiatry 69(5):817–829
Mi W, Liu F, Liu Y, Du B, Xiao W, Li L, Huang L, Lu T, He J, Shi L, Yue W, Zhang H (2016) Association of ABCB1 gene polymorphisms with efficacy and adverse reaction to risperidone or paliperidone in han chinese schizophrenic patients. Neurosci Bull 32 (6):547–549. https://doi.org/10.1007/s12264-016-0050-9
Narum SR (2006) Beyond bonferroni: less conservative analyses for conservation genetics. Conserv Genet 7(5):783–787
Pouget JG, Shams TA, Tiwari AK, Muller DJ (2014) Pharmacogenetics and outcome with antipsychotic drugs. Dialogues Clin Neurosci 16(4):555–566
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81(3):559–575. https://doi.org/10.1086/519795
Wang D, Fu DJ, Wu X, Shapiro A, Favis R, Savitz A, Chung H, Alphs L, Gopal S, Haas M, Cohen N, Li Q (2015) Large-scale candidate gene study to identify genetic risk factors predictive of paliperidone treatment response in patients with schizophrenia. Pharmacogenet Genom 25(4):173–185. https://doi.org/10.1097/FPC.0000000000000122
Zhang JP, Malhotra AK (2011) Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction. Expert Opin Drug Metab Toxicol 7(1):9–37. https://doi.org/10.1517/17425255.2011.532787
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This research was supported by the National Natural Science Foundation of China (Nos. 81630031, 81571312), Capital Medical Development Research Fund (2016-1-4111), Beijing Municipal Science and Technology Project (Z171100000117016) and National Key Technology R&D Program (2015BAI13B01).
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Su, YA., Bousman, C., Li, Q. et al. Genetic variations in the ADCK1 gene predict paliperidone palmitate efficacy in Han Chinese patients with schizophrenia. J Neural Transm 126, 19–25 (2019). https://doi.org/10.1007/s00702-018-1953-6
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DOI: https://doi.org/10.1007/s00702-018-1953-6