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Iron, cysteine and Parkinson’s disease

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Abstract

A short review of the role of cysteine and iron in the progression of Parkinson’s disease is presented. The complex chemistry of cysteine and iron and its interactions are discussed and put into the context of oxidative stress during neurodegeneration.

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References

  1. de Rijk MC, Tzourio C, Breteler MM, Dartigues JF, Amaducci L, Lopez-Pousa S, Manubens-Bertran JM, Alperovitch A, Rocca WA (1997) J Neurol Neurosurg Psychiatry 62:10

    Article  Google Scholar 

  2. Dawson TM, Dawson VL (2003) Science 302:819

    Article  CAS  Google Scholar 

  3. van der Walt JM, Nicodemus KK, Martin ER, Scott WK, Nance MA, Watts RL, Hubble JP, Haines JL, Koller WC, Lyons K, Pahwa R, Stern MB, Colcher A, Hiner BC, Jankovic J, Ondo WG, Allen FH, Goetz CG, Small GW, Mastaglia F, Stajich JM, McLaurin AC, Middleton LT, Scott BL, Schmechel DE, Pericak-Vance MA, Vance JM (2003) Am J Hum Genet 72:804

    Article  Google Scholar 

  4. Sherer TB, Betarbet R, Greenamyre JT (2002) Neuroscientist 8:192

    CAS  Google Scholar 

  5. Sayre LM, Perry G, Smith MA (2008) Chem Res Toxicol 21:172

    Article  Google Scholar 

  6. Linert W, Herlinger E, Jameson RF, Kienzl E, Jellinger K, Youdim MBH (1996) Biochim Biophys Acta 1316:160

    Google Scholar 

  7. Napolitano A, Pezzella A, Prota G (1999) Chem Res Toxicol 12:1090

    Article  CAS  Google Scholar 

  8. Searle AJ, Willson RL (1983) Biochem J 212:549

    CAS  Google Scholar 

  9. Groves JT (2006) J Inorg Biochem 100:434

    Article  CAS  Google Scholar 

  10. Gazit V, Ben-Abraham R, Coleman R, Weizman A, Katz Y (2004) Amino Acids 26:163

    Article  CAS  Google Scholar 

  11. Linert W, Jameson GN (2000) J Inorg Biochem 79:319

    Article  CAS  Google Scholar 

  12. McBean G (2007) 7 Sulfur-containing amino acids. In: Lajtha A, Oja S, Schousboe A, Saransaari P (eds) Handbook of neurochemistry and molecular neurobiology. Springer, USA

    Google Scholar 

  13. Olney JW, Zorumski C, Price MT, Labruyere J (1990) Science 248:596

    Article  CAS  Google Scholar 

  14. Puka-Sundvall M, Eriksson P, Nilsson M, Sandberg M, Lehmann A (1995) Brain Res 705:65

    Article  CAS  Google Scholar 

  15. Stipanuk MH, Dominy JE Jr, Lee JI, Coloso RM (2006) J Nutr 136:1652S

    CAS  Google Scholar 

  16. Townsend DM, Tew KD, Tapiero H (2004) Biomed Pharmacother 58:47

    Article  CAS  Google Scholar 

  17. Janaky R, Varga V, Hermann A, Saransaari P, Oja SS (2000) Neurochem Res 25:1397

    Article  CAS  Google Scholar 

  18. Dexter DT, Wells FR, Lees AJ, Agid F, Agid Y, Jenner P, Marsden CD (1989) J Neurochem 52:1830

    Article  CAS  Google Scholar 

  19. Gerlach M, Benshachar D, Riederer P, Youdim MBH (1994) J Neurochem 63:793

    Article  CAS  Google Scholar 

  20. Ye S, Wu X, Wei L, Tang DM, Sun P, Bartlam M, Rao ZH (2007) J Biol Chem 282:3391

    Article  CAS  Google Scholar 

  21. Jameson RF, Linert W, Tschinkowitz A (1988) J Chem Soc Dalton Trans 2109

  22. Jameson RF, Linert W, Tschinkowitz A, Gutmann V (1988) J Chem Soc Dalton Trans 943

  23. Berthon G (1995) Pure Appl Chem 67:1117

    Article  CAS  Google Scholar 

  24. Jameson GNL, Zhang J, Jameson RF, Linert W (2004) Org Biomol Chem 2:777

    Article  CAS  Google Scholar 

  25. Wakamatsu K, Fujikawa K, Zucca FA, Zecca L, Ito S (2003) J Neurochem 86:1015

    Article  CAS  Google Scholar 

  26. Zecca L, Zucca FA, Wilms H, Sulzer D (2003) Trends Neurosci 26:578

    Article  CAS  Google Scholar 

  27. Bush WD, Garguilo J, Zucca FA, Albertini A, Zecca L, Edwards GS, Nemanich RJ, Simon JD (2006) Proc Natl Acad Sci U S A 103:14785

    Article  CAS  Google Scholar 

  28. Zecca L, Mecacci C, Seraglia R, Parati E (1992) Biochim Biophys Acta 1138:6

    CAS  Google Scholar 

  29. ElAyaan U, Herlinger E, Jameson RF, Linert W (1997) J Chem Soc Dalton Trans 2813

  30. Herlinger E, Jameson RF, Linert W (1995) J Chem Soc Perkin 2:259

    Google Scholar 

  31. Jameson GNL, Jameson RF, Linert W (2004) Org Biomol Chem 2:2346

    Article  CAS  Google Scholar 

  32. Double KL, Gerlach M, Schunemann V, Trautwein AX, Zecca L, Gallorini M, Youdim MBH, Riederer P, Ben-Shachar D (2003) Biochem Pharmacol 66:489

    Article  CAS  Google Scholar 

  33. Shen XM, Dryhurst G (1996) Chem Res Toxicol 9:751

    Article  CAS  Google Scholar 

  34. Shen XM, Dryhurst G (1998) Chem Res Toxicol 11:824

    Article  CAS  Google Scholar 

  35. Shen XM, Zhang F, Dryhurst G (1997) Chem Res Toxicol 10:147

    Article  CAS  Google Scholar 

  36. Zhang F, Dryhurst G (1994) J Med Chem 37:1084

    Article  CAS  Google Scholar 

  37. Sevilla MD, Yan MY, Becker D (1988) Biochem Biophys Res Commun 155:405

    Article  CAS  Google Scholar 

  38. Ehrenberg L, Harmsringdahl M, Fedorcsak I, Granath F (1989) Acta Chem Scand 43:177

    Article  CAS  Google Scholar 

  39. Claiborne A, Miller H, Parsonage D, Ross RP (1993) FASEB J 7:1483

    CAS  Google Scholar 

  40. Enami S, Hoffmann MR, Colussi AJ (2009) J Phys Chem B 113:9356

    Article  CAS  Google Scholar 

  41. Nagy P, Ashby MT (2007) J Am Chem Soc 129:14082

    Article  CAS  Google Scholar 

  42. Hawkins CL, Pattison DI, Davies MJ (2003) Amino Acids 25:259

    Article  CAS  Google Scholar 

  43. Choi D-K, Pennathur S, Perier C, Tieu K, Teismann P, Wu D-C, Jackson-Lewis V, Vila M, Vonsattel J-P, Heinecke JW, Przedborski S (2005) J Neurosci 25:6594

    Article  CAS  Google Scholar 

  44. Siakkou E, Wilbanks SM, Jameson GNL (2010) Anal Biochem 405:127

    Article  CAS  Google Scholar 

  45. Kleffmann T, Jongkees SAK, Fairweather G, Wilbanks SM, Jameson GNL (2009) J Biol Inorg Chem 14:913

    Article  CAS  Google Scholar 

  46. Dominy JE, Hirschberger LL, Coloso RM, Stipanuk MH (2006) Biochem J 394:267

    Article  CAS  Google Scholar 

  47. McNaught KSP, Olanow CW, Halliwell B, Isacson O, Jenner P (2001) Nat Rev Neurosci 2:589

    Article  CAS  Google Scholar 

  48. Muller T, Kuhn W (2009) Mov Disord 24:929

    Article  Google Scholar 

  49. Heafield MT, Fearn S, Steventon GB, Waring RH, Williams AC, Sturman SG (1990) Neurosci Lett 110:216

    Article  CAS  Google Scholar 

  50. Sofic E, Riederer P, Heinsen H, Beckmann H, Reynolds GP, Hebenstreit G, Youdim MBH (1988) J Neural Transm 74:199

    Article  CAS  Google Scholar 

  51. Lenz GR, Martell AE (1964) Biochemistry 3:745

    Article  CAS  Google Scholar 

  52. Jameson RF, Linert W (1991) Monatsh Chem 122:887

    Article  CAS  Google Scholar 

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Acknowledgments

I am grateful to Prof. R. F. Jameson and Dr. V. J. A. Jameson for useful discussions and to the Marsden Fund of the Royal Society of New Zealand for financial support.

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Authors and Affiliations

  1. Department of Chemistry, University of Otago, P.O. Box 56, Dunedin, 9054, New Zealand

    Guy N. L. Jameson

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  1. Guy N. L. Jameson
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Correspondence to Guy N. L. Jameson.

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Jameson, G.N.L. Iron, cysteine and Parkinson’s disease. Monatsh Chem 142, 325–329 (2011). https://doi.org/10.1007/s00706-011-0475-9

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  • DOI: https://doi.org/10.1007/s00706-011-0475-9

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