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Treatment of frozen shoulder with subcutaneous TNF-alpha blockade compared with local glucocorticoid injection: a randomised pilot study

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Abstract

We compared the effect of subcutaneous adalimumab injections with intraarticular glucocorticoid injections on frozen shoulder of 18 patients with unilateral joint involvement. Ten patients were randomised to subcutaneous injections with adalimumab and eight to intraarticular glucocorticoid injections administered every other week for a total of three administrations. The evaluation included validated scores. No effect of subcutaneous injections of adalimumab on frozen shoulder symptoms was demonstrated.

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Acknowledgments

This study was funded by Abbot Pharmaceuticals, Denmark. Abbott Denmark had no influence on, or involvement in, the planning or design of the study, data collection, data analysis or manuscript preparation. We thank Abbott Pharmaceuticals for the financial support and technical assistance.

Disclosures

Pierre Schydlowsky has received consulting fees from Abbott. Ole Rintek Madsen has received consulting fees, speaking fees and research grants from Abbott. Marcin Szkudlarek has no financial grants to disclose.

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Authors and Affiliations

  1. Arthro Rheumatology Clinic, Bymidten 11, 1., 3500, Værløse, Denmark

    Pierre Schydlowsky

  2. Department of Rheumatology, University of Copenhagen Hospital at Køge, Køge, Denmark

    Marcin Szkudlarek

  3. Department of Medicine C/Rheumatology Unit, Copenhagen University Hospital Gentofte, Hellerup, Denmark

    Ole Rintek Madsen

Authors
  1. Pierre Schydlowsky
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  2. Marcin Szkudlarek
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  3. Ole Rintek Madsen
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Corresponding author

Correspondence to Pierre Schydlowsky.

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Schydlowsky, P., Szkudlarek, M. & Madsen, O.R. Treatment of frozen shoulder with subcutaneous TNF-alpha blockade compared with local glucocorticoid injection: a randomised pilot study. Clin Rheumatol 31, 1247–1251 (2012). https://doi.org/10.1007/s10067-012-1993-5

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  • DOI: https://doi.org/10.1007/s10067-012-1993-5

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