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Characterization of an osteomyelitis case caused by dalbavancin, ceftaroline, and vancomycin non-susceptible methicillin-resistant Staphylococcus aureus

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Abstract

We report a case of osteomyelitis due to methicillin-resistant Staphylococcus aureus (MRSA) that is also non-susceptible to vancomycin, dalbavancin, ceftaroline, and ceftobiprole, in the absence of exposure to the latter three antibiotics. It was isolated from a patient with a 26-year history of cranial surgeries and episodes of osteomyelitis. Whole-genome sequencing was performed. It was found to belong to ST247 and the mecA gene was detected within the SSCmec type I (1B) gene cassette that lacked the E447K mutation known to produce resistance to ceftobiprole and ceftaroline. However, mutations in other genes related to resistance to these antibiotics were found.

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Authors and Affiliations

  1. Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain

    Elias Dahdouh, Iker Falces-Romero, Jesús Mingorance & Rosa Gómez-Gil

  2. Clinical Microbiology and Infectious Diseases Unit, Hospital Universitario La Paz, Madrid, Spain

    Beatriz Díaz-Pollán

Authors
  1. Elias Dahdouh
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  2. Beatriz Díaz-Pollán
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  3. Iker Falces-Romero
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  4. Jesús Mingorance
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  5. Rosa Gómez-Gil
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Correspondence to Elias Dahdouh.

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Dahdouh, E., Díaz-Pollán, B., Falces-Romero, I. et al. Characterization of an osteomyelitis case caused by dalbavancin, ceftaroline, and vancomycin non-susceptible methicillin-resistant Staphylococcus aureus. Eur J Clin Microbiol Infect Dis 40, 2029–2032 (2021). https://doi.org/10.1007/s10096-021-04219-0

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  • DOI: https://doi.org/10.1007/s10096-021-04219-0

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