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A mechanostatistical approach to cortical bone remodelling: an equine model

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Abstract

In this study, the development of a mechanostatistical model of three-dimensional cortical bone remodelling informed with in vivo equine data is presented. The equine model was chosen as it is highly translational to the human condition due to similar Haversian systems, availability of in vivo bone strain and biomarker data, and furthermore, equine models are recommended by the US Federal Drugs Administration for comparative joint research. The model was derived from micro-computed tomography imaged specimens taken from the equine third metacarpal bone, and the Frost-based ‘mechanostat’ was informed from both in vivo strain gauges and biomarkers to estimate bone growth rates. The model also described the well-known ‘cutting cone’ phenomena where Haversian canals tunnel and replace bone. In order to make this model useful in practice, a partial least squares regression (PLSR) surrogate model was derived based on training data from finite element simulations with different loads. The PLSR model was able to predict microstructure and homogenised Young’s modulus with errors less than 2.2 % and \(0.6\,\% \), respectively.

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Acknowledgments

This work was funded by the Ministry of Business, Innovation and Employment (MBIE) of New Zealand. The authors of this work acknowledge Benedicta Arhatari of the Physics Department of LaTrobe University for the micro-CT work.

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Authors and Affiliations

  1. Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand

    X. Wang & J. W. Fernandez

  2. Melbourne Dental School, University of Melbourne, Parkville, VIC, Australia

    C. D. L. Thomas & J. G. Clement

  3. Department of Mechanical Engineering, The University of Auckland, Auckland, New Zealand

    R. Das

  4. Faculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, VIC, Australia

    H. Davies

  5. Department of Engineering Science, The University of Auckland, Auckland, New Zealand

    J. W. Fernandez

Authors
  1. X. Wang
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  2. C. D. L. Thomas
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  3. J. G. Clement
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  4. R. Das
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  5. H. Davies
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  6. J. W. Fernandez
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Correspondence to X. Wang.

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Wang, X., Thomas, C.D.L., Clement, J.G. et al. A mechanostatistical approach to cortical bone remodelling: an equine model. Biomech Model Mechanobiol 15, 29–42 (2016). https://doi.org/10.1007/s10237-015-0669-x

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  • DOI: https://doi.org/10.1007/s10237-015-0669-x

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