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Influence of vessel curvature and plaque composition on drug transport in the arterial wall following drug-eluting stent implantation

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Abstract

In the last decade, many computational models have been developed to describe the transport of drug eluted from stents and the subsequent uptake into arterial tissue. Each of these models has its own set of limitations: for example, models typically employ simplified stent and arterial geometries, some models assume a homogeneous arterial wall, and others neglect the influence of blood flow and plasma filtration on the drug transport process. In this study, we focus on two common limitations. Specifically, we provide a comprehensive investigation of the influence of arterial curvature and plaque composition on drug transport in the arterial wall following drug-eluting stent implantation. The arterial wall is considered as a three-layered structure including the subendothelial space, the media and the adventitia, with porous membranes separating them (endothelium, internal and external elastic lamina). Blood flow is modelled by the Navier–Stokes equations, while Darcy’s law is used to calculate plasma filtration through the porous layers. Our findings demonstrate that arterial curvature and plaque composition have important influences on the spatiotemporal distribution of drug, with potential implications in terms of effectiveness of the treatment. Since the majority of computational models tend to neglect these features, these models are likely to be under- or over-estimating drug uptake and redistribution in arterial tissue.

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Acknowledgements

This work was funded by the Spanish Ministry of Economy, Industry and Competitiveness through research Project No. DPI2016-76630-C2-1-R and Grant No. BES-2014-069737; the Department of Industry and Innovation (Government of Aragon) through research group Grant No. T24-17R (Fondo Social Europeo) and research Project No. LMP121-18; and the Carlos III Health Institute (ISCIII) through the CIBER initiative. Dr. McGinty acknowledges funding provided by EPSRC (Grant No. EP/S030875/1).

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Authors and Affiliations

  1. Aragón Institute for Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain

    Javier Escuer, Irene Aznar, Estefanía Peña & Miguel A. Martínez

  2. Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK

    Christopher McCormick

  3. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Zaragoza, Spain

    Estefanía Peña & Miguel A. Martínez

  4. Division of Biomedical Engineering, University of Glasgow, Glasgow, UK

    Sean McGinty

  5. María de Luna, 3, 50018, Zaragoza, Spain

    Miguel A. Martínez

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  1. Javier Escuer
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  2. Irene Aznar
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  4. Estefanía Peña
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  5. Sean McGinty
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  6. Miguel A. Martínez
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Correspondence to Miguel A. Martínez.

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Escuer, J., Aznar, I., McCormick, C. et al. Influence of vessel curvature and plaque composition on drug transport in the arterial wall following drug-eluting stent implantation. Biomech Model Mechanobiol 20, 767–786 (2021). https://doi.org/10.1007/s10237-020-01415-3

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