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Activités antioxydante et antiplasmodiale d’extraits de Massularia acuminata (Rubiaceae)

Antioxidant and antiplasmodial activities of extracts of Massularia acuminata (Rubiaceae)

  • Phytothérapie Vétérinaire
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Phytothérapie

Résumé

L’utilisation de Massularia acuminata (MA) par les populations Nkundo en médecine traditionnelle à Lui-Kotale en R.D. Congo aussi bien que par les bonobos nous a amenés à des investigations pharmacognosiques et phytochimiques. Le screening phytochimique des extraits aqueux de fruits (AF) et EtOH 80% d’écorces de tronc (EE) de MA ont révélé la présence d’alcaloïdes, flavonoïdes, leucoanthocyanes, saponosides et tanins. Mais également la présence d’anthocyanes, oses et holosides, quinones, sucres réducteurs dans les extraits AF, et ceux d’EE de stérols et triterpènes. La meilleure activité antioxydante est obtenue avec les extraits d’EE (CI50 = 27,45 ± 2,56 µg/ml), et la plus forte activité antiplasmodiale avec ceux d’AF (CI50 < 9,77 µg/ml) de MA. Ces résultats suggéreraient un possible comportement d’automédication, auxquels s’ajouteraient les besoins nutritionnels pour le bien-être de la santé animale.

Abstract

Using Massularia acuminata (MA) by by Nkundo populations in traditional medicine at Lui-Kotale in D.R. Congo, and by both bonobos and has led us to pharmacognostic and phytochemical investigations. The phytochemical screening of the aqueous extracts of fruit (AF) and EtOH 80% bark trunk (EA) of MA revealed the presence of alkaloids, flavonoids, leucoanthocyanes, saponins and tannins. But also the presence of anthocyanins, monosaccharides and holosides, quinones, reducing sugars in the AF, and those extracts EA sterols and triterpenes. The best antioxidant activity was obtained with extracts of EA (IC50 = 27.45 ± 2.56 mg/ml), and the highest antiplasmodial activity with those of AF (IC50 < 9.77 mg/ml) of MA. These results suggest a possible selfmedication behavior, which in addition to the nutritional needs for the welfare of the animal health.

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Authors and Affiliations

  1. Comité scientifique pour la recherche, la conservation et le développement de la biodiversité, département de biologie, Faculté des sciences, université de Kinshasa, BP 190, Kinshasa XI, Congo

    U. Maloueki, I. D. Mbomba, K. N. Ngbolua, K. S. P. Ndimbo & N. B. Mbomba

  2. Département des Sciences de base, service de physiologie, Faculté de Médecine, université de Kinshasa, BP 834, Kinshasa XI, Congo

    K. P. Kunyima

  3. Service de parasitologie, Institut National de Recherche biomédicale, avenue de la Démocratie, Kinshasa, Congo

    N. A. Dani & K. A. Lukuka

  4. Programme national de lutte contre le paludisme, Kinshasa, Congo

    K. A. Lukuka

  5. Département de chimie médicinale et pharmacognosie, faculté des Sciences Pharmaceutiques, université de Kinshasa, BP 212, Kinshasa XI, Congo

    N. J. Lami & C. D. Musuyu Muganza

  6. Laboratoire des substances naturelles et chimie médicinale, département de chimie, faculté des Sciences, université de Kinshasa, BP 190, Kinshasa XI, Congo

    P. T. Mpiana & K. N. Ngbolua

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  1. U. Maloueki
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  2. K. P. Kunyima
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  3. I. D. Mbomba
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  8. K. N. Ngbolua
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  9. K. S. P. Ndimbo
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  10. N. B. Mbomba
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  11. C. D. Musuyu Muganza
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Maloueki, U., Kunyima, K.P., Mbomba, I.D. et al. Activités antioxydante et antiplasmodiale d’extraits de Massularia acuminata (Rubiaceae). Phytothérapie 13, 389–395 (2015). https://doi.org/10.1007/s10298-015-0937-z

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