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Diffusion imaging for evaluation of tumor therapies in preclinical animal models

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Abstract

The increasing development of novel targeted therapies for treating solid tumors has necessitated the development of technology to determine their efficacy in preclinical animal models. One such technology that can non-invasively quantify early changes in tumor cellularity as a result of an efficacious therapy is diffusion MRI. In this overview we present some theories as to the origin of diffusion changes as a result of tumor therapy, a robust methodology for acquisition of apparent diffusion coefficient maps and some applications of determining therapeutic efficacy in a variety therapeutic regimens and animal models.

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Acknowledgments.

This work was supported by the following research grants: NIH/NCI PO1CA85878, P50CA093990, and R24CA83099

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Authors and Affiliations

  1. Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, 1150 W. Medical Center Drive, MSRB III Rm 9303, Ann Arbor, MI, 48109-0503, USA

    B. A. Moffat, D. E. Hall, J. Stojanovska, T. L. Chenevert & B. D. Ross

  2. Department of Radiation Oncology, University of Michigan, Ann Arbor, 1150 W. Medical Center Drive, MSRB III Rm 9303, Ann Arbor, MI, 48109-0503, USA

    A. Rehemtulla

  3. Molecular Imaging Research, 924 N. Main, Ann Arbor, MI, 48104, USA

    P. J. McConville & J. B. Moody

Authors
  1. B. A. Moffat
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  2. D. E. Hall
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  3. J. Stojanovska
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  4. P. J. McConville
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  5. J. B. Moody
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  6. T. L. Chenevert
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  7. A. Rehemtulla
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  8. B. D. Ross
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Corresponding author

Correspondence to B. A. Moffat.

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Moffat, B., Hall, D., Stojanovska, J. et al. Diffusion imaging for evaluation of tumor therapies in preclinical animal models. MAGMA 17, 249–259 (2004). https://doi.org/10.1007/s10334-004-0079-z

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  • DOI: https://doi.org/10.1007/s10334-004-0079-z

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