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Comparison of the Additive Effects of Nipradilol and Carteolol to Latanoprost in Open-Angle Glaucoma

  • CLINICAL INVESTIGATION
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Abstract

Purpose

To compare the effects of nipradilol and carteolol on intraocular pressure (IOP) when added to latanoprost treatment for glaucoma patients.

Methods

Fifty patients with primary open-angle glaucoma were treated with latanoprost 0.005% once daily for 3 months. Then they were assigned to one of two groups randomly. One group received nipradilol 0.25% twice daily (nipradilol preceding group; n = 25), and the other carteolol hydrochloride 2% twice daily (carteolol preceding group; n = 25), for 3 months in addition to latanoprost. Then, nipradilol and carteolol were switched, and the subjects were treated for 3 more months. One eye was selected randomly for analysis.

Results

In the nipradilol preceding group, IOP was 21.4 ± 2.3 mmHg (mean ± SD) at baseline, and 16.8 ± 1.9 mmHg at the end of latanoprost monotherapy (P < 0.01). The addition of nipradilol decreased IOP to 15.8 ± 1.7 mmHg, and the change to carteolol, to 15.3 ± 2.0 mmHg. In the carteolol preceding group, IOP was 21.2 ± 2.0 mmHg at baseline, and 17.0 ± 2.1 mmHg at the end of latanoprost monotherapy (P < 0.01). The addition of carteolol decreased IOP to 15.4 ± 1.8 mmHg, and the change to nipradilol, to 16.3 ± 1.9 mmHg. Additional IOP reduction was greater with carteolol than with nipradilol (cross-over analysis of variance; P = 0.0005).

Conclusions

Both nipradilol and carteolol have additive effects when used in combination with latanoprost. Carteolol, however, may have a more potent effect than nipradilol. Jpn J Ophthalmol 2006;50:33–37 © Japanese Ophthalmological Society 2006

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Authors and Affiliations

  1. Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan

    Mai Haneda, Shiroaki Shirato & Katsuhiko Maruyama

  2. Department of Mathematical Health Science, Course of Health Science, Graduate School of Medicine, Osaka University, Osaka, Japan

    Yuko Ohno

Authors
  1. Mai Haneda
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  2. Shiroaki Shirato
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  3. Katsuhiko Maruyama
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  4. Yuko Ohno
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Corresponding author

Correspondence to Mai Haneda.

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Haneda, M., Shirato, S., Maruyama, K. et al. Comparison of the Additive Effects of Nipradilol and Carteolol to Latanoprost in Open-Angle Glaucoma. Jpn J Ophthalmol 50, 33–37 (2006). https://doi.org/10.1007/s10384-005-0256-2

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  • DOI: https://doi.org/10.1007/s10384-005-0256-2

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