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Y- and T-junction microfluidic devices: effect of fluids and interface properties and operating conditions

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Abstract

Water-in-oil emulsions were produced in microchannels with Y- and T-junction geometries by individual droplet generation. For each microchannel configuration, the effect of the fluids and interface properties as well as of the process conditions was evaluated. The size of the droplets depended mainly on the relative velocity between continuous and dispersed phases and the relative fluid viscosity between phases. Those variables were related to the shear stress between the phases, which caused the droplet detachment. In addition, the interfacial forces played a minor role in Y-junction, and they had no effect in the droplets formation in T-junction microchannels. In Y-junction, a large variation in the droplet size was observed, depending on the system composition and the operating conditions. At low relative velocity and fluid viscosity, no droplets were generated. In contrast, the process in T-junction resulted in a lower variation of droplets size and the droplets were formed even at less favorable conditions. Such results indicate that the knowledge of the mechanism of droplets generation in each microchannel geometry makes it possible to choose the appropriate configuration according to the type of fluid, and the operating conditions can be adjusted to obtain the desired final emulsion.

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References

  • Abate AR, Poitzsch A, Hwang Y, Lee J, Czerwinska J, Weitz DA (2009) Impact of inlet channel geometry on microfluidic drop formation. Phys Rev E 80:026310

    Article  Google Scholar 

  • Abate AR, Thiele J, Weitz DA (2011) One-step formation of multiple emulsions in microfluidics. Lab Chip 11:253–258

    Article  Google Scholar 

  • Anna SL, Bontoux N, Stone HA (2003) Formation of dispersions using “flow focusing” in microchannels. Appl Phys Lett 82:364–366

    Article  Google Scholar 

  • Atencia J, Beebe DJ (2005) Controlled microfluidic interfaces. Nature 437:648–655

    Article  Google Scholar 

  • Bassous E, Taub HH, Kuhn L (1977) Ink jet printing nozzle arrays etched in silicon. Appl Phys Lett 31:135–137

    Article  Google Scholar 

  • Bauer WAC, Fischlechner M, Abell C, Huck WTS (2010) Hydrophilic PDMS microchannels for high-throughput formation of oil-in-water microdroplets and water-in-oil-in-water double emulsions. Lab Chip 10:1814–1819

    Article  Google Scholar 

  • Choi CH, Jung JH, Rhee YW, Kim DP, Shim SE, Lee CS (2007) Generation of monodisperse alginate microbeads and in situ encapsulation of cell in microfluidic device. Biomed Microdevices 9:855–862

    Article  Google Scholar 

  • De Menech M, Garstecki P, Jousse F, Stone HA (2008) Transition from squeezing to dripping in a microfluidic T-shaped junction. J Fluid Mech 595:141–161

    Article  MATH  Google Scholar 

  • Garstecki P (2010) Formation of droplets and bubbles in microfluidic systems. In: Kakaç S, Kosoy B, Pramuanjaroenkij A (eds) Microfluidics based microsystems: fundamentals and applications. Springer, The Netherlands, pp 163–181

    Chapter  Google Scholar 

  • Garstecki P, Stone HA, Whitesides GM (2005) Mechanism for flow-rate controlled breakup in confined geometries: a route to monodisperse emulsions. Phys Rev Lett 94:164501

    Article  Google Scholar 

  • Garstecki P, Fuerstman MJ, Stone HA, Whitesides GM (2006) Formation of droplets and bubbles in a microfluidic T-junction—scaling and mechanism of break-up. Lab Chip 6:437–446

    Article  Google Scholar 

  • Gupta A, Kumar R (2010) Effect of geometry on droplet formation in the squeezing regime in a microfluidic T-junction. Microfluid Nanofluid 8:799–812

    Article  Google Scholar 

  • Harris KR, Woolf LA (2004) Temperature and volume dependence of the viscosity of water and heavy water at low temperatures. J Chem Eng Data 49:1064–1069

    Article  Google Scholar 

  • Liu H, Zhang Y (2011) Droplet formation in microfluidic cross-junctions. Phys Fluids 23(082101):1–12

    Google Scholar 

  • Liu L, Wu F, Ju XJ, Xie R, Wang W, Niu CH, Chu LY (2013) Preparation of monodisperse calcium alginate microcapsules via internal gelation in microfluidic-generated double emulsions. J Colloid Interface Sci 404:85–90

    Article  Google Scholar 

  • Manz A, Harrison DJ, Verpoorte EMJ, Fettinger JC, Paulus A, Lüdi H, Widmer HM (1992) Planar chips technology for miniaturization and integration of separation techniques into monitoring systems. J Chromatogr 593:253–258

    Article  Google Scholar 

  • McDonald JC, Whitesides GM (2002) Poly(dimethylsiloxane) as a material for fabricating microfluidic devices. Acc Chem Res 35:491–499

    Article  Google Scholar 

  • McDonald JC, Duffy DC, Anderson JR, Chiu DT, Wu H, Schueller OJA, Whitesides GM (2000) Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 21:27–40

    Article  Google Scholar 

  • Nie Z, Seo M, Xu S, Lewis PC, Mok M, Kumacheva E, Whitesides GM, Garstecki P, Stone HA (2008) Emulsification in a microfluidic flow-focusing device: effect of the viscosities of the liquids). Microfluid Nanofluid 5:585–594

    Article  Google Scholar 

  • Sivasamy J, Wong TN, Nguyen NT, Kao LTH (2011) An investigation on the mechanism of droplet formation in a microfluidic T-junction. Microfluid Nanofluid 11:1–10

    Article  Google Scholar 

  • Squires TM, Quake SR (2005) Microfluidics: fluid physics at the nanoliter scale. Rev Mod Phys 77:977–1026

    Article  Google Scholar 

  • Steegmans MLJ, Schroën KGPH, Boom RM (2009a) Characterization of emulsification at flat microchannel Y junctions. Langmuir 25:3396–3401

    Article  Google Scholar 

  • Steegmans MLJ, Schroën CGPH, Boom RM (2009b) Generalised insights in droplet formation at T-junctions through statistical analysis. Chem Eng Sci 64:3042–3050

    Article  Google Scholar 

  • Steegmans MLJ, De Ruiter J, Schroën KGPH, Boom RM (2010) A descriptive force-balance model for droplet formation at microfluidic Y-junctions. AIChE J 56:2641–2649

    Article  Google Scholar 

  • Sugiura S, Nakajima M, Yamamoto K, Iwamoto S, Oda T, Satake M, Seki M (2004) Preparation characteristics of water-in-oil-in-water multiple emulsions using microchannel emulsification. J Colloid Interface Sci 270:221–228

    Article  Google Scholar 

  • Sugiura S, Oda T, Izumida Y, Aoyagi Y, Satake M, Ochiai A, Ohkohchi N, Nakajima M (2005) Size control of calcium alginate beads containing living cells using micro-nozzle array. Biomaterials 26:3327–3331

    Article  Google Scholar 

  • Tan WH, Takeuchi S (2007) Monodisperse alginate hydrogel microbeads for cell encapsulation. Adv Mater 19:2696–2701

    Article  Google Scholar 

  • Thorsen T, Roberts RW, Arnold FH, Quake SR (2001) Dynamic pattern formation in a vesicle-generating microfluidic device. Phys Rev Lett 86:4163–4166

    Article  Google Scholar 

  • Turmakin E, Kumacheva E (2009) Microfluidic generation of microgels from synthetic and natural polymers. Chem Soc Rev 38:2161–2168

    Article  Google Scholar 

  • Ushikubo FY, Cunha RL (2014) Stability mechanisms of liquid water-in-oil emulsions. Food Hydrocoll 34:145–153

    Article  Google Scholar 

  • Utada AS, Fernandez-Nieves A, Stone HA, Weitz DA (2007) Dripping to jetting transitions in coflowing liquid streams. Phys Rev Lett 99:094502

    Article  Google Scholar 

  • Vladisavljević GT, Kobayashi I, Nakajima M (2012) Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices. Microfluid Nanofluid 13:151–178

    Article  Google Scholar 

  • Xu B, Ooi KT, Wong NT, Choi WK (2000) Experimental investigation of flow friction for liquid flow in microchannels. Int Commun Heat Mass 27:1165–1176

    Article  Google Scholar 

  • Xu JH, Li SW, Tan J, Luo GS (2008) Correlations of droplet formation in T-junction microfluidic devices: from squeezing to dripping. Microfluid Nanofluid 5:711–717

    Article  Google Scholar 

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Acknowledgments

The authors appreciate the technical support given by Professor Angelo Gobbi and Maria Helena de Oliveira Piazzeto of the Microfabrication Laboratory at the Brazilian Center for Research in Energy and Materials (CNPEM). The authors also would like to thank São Paulo Foundation (FAPESP 2009/54.137-1, 2010/16.708-4 and 2011/06.083-0) and National Council for Scientific and Technological Development (CNPq 304611/2009-3) for supporting this research.

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Correspondence to R. L. Cunha.

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Ushikubo, F.Y., Birribilli, F.S., Oliveira, D.R.B. et al. Y- and T-junction microfluidic devices: effect of fluids and interface properties and operating conditions. Microfluid Nanofluid 17, 711–720 (2014). https://doi.org/10.1007/s10404-014-1348-4

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  • DOI: https://doi.org/10.1007/s10404-014-1348-4

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