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Phytotherapy and combined nanoformulations as a promising disease management in aquaculture: a review

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Abstract

Aquaculture-based foods have enriched nutritional and medicinal value to meet the needs of the global population. Recently, improper maintenance of aquatic organisms in aquaculture sector led to the outbreak of infectious diseases by pathogens. Treatment of disease by conventional methods (chemical) causes adverse effects to culturing organisms, the environment, and even to consumers. As an alternative to conventional methods, a variety of medicinal plant compounds like curcumin, quercetin, silymarin, Ajoene, and caffeic acid were used for disease control since they enhance the non-specific immunity. Phytotherapy-based techniques/compounds were preferred by aqua industry to develop resistance against a variety of aquatic pathogens in culture organisms since they are inexpensive and eco-friendly. Recent advances in nanotechnology pave the way to incorporate various medicinal plant-based nanoformulations to control aquatic microbial pathogens. Therefore, this review expresses in detail the versatile uses of phytotherapies and their based nanoformulation as a promising tool for disease management in aquaculture.

Highlights

• Aquaculture and their food was highly nutritive, market value. During culture practices easily affected by pathogens leads to loss of social—economic value.

• Using of chemicals causes adverse effects in culturing organisms, consumer producer and environment.

• In this review explains about using of herbs and their consequences in aquaculture industry and their beneficial effects such as increase production rate, stress relief agent, Aphrodisiac activity, Anti- pathogenic activity and also act as immunostimulants.

• Using of herbal based medicine in aquaculture industry safe to environment, farmer, consumer level. Hence to farming “ORGANIC AQUACULTURE”

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References

  • Abdel Tawwab M, Ahmad MH, Seden ME, Sakr SF (2010) Use of green tea, Camellia sinensis L., in practical diet for growth and protection of Nile tilapia, Oreochromis niloticus (L.), against Aeromonas hydrophila infection. J World Aquac Soc 41:203–213

    Article  Google Scholar 

  • Amani Denji K, Soltani M, Rajabi H, Kamali A (2020) The antifungal effect of Allium sativum and Artemisia sieberia extracts on hatching and survival of Oncorhynchus mykiss larvae. Iran J Fish Sci 19:669–680

    Google Scholar 

  • Arunachalam K.D., Kuruva J.K., Pradhoshinik., Musthafa M.S., Faggio C. (2021). Antioxidant and antigenotoxic potential of Morinda tinctoria Roxb. leaf extract succeeding cadmium exposure in Asian cat fish, Pangasius sutchi. Comparative Biochemistry and Physiology, Part C in press

  • Awad E, El-Fiqi A, Austin D, Lyndon A (2020) Possible effect of lesser galangal (Alpinia officinarum) extracts encapsulated into mesoporous silica nanoparticles on the immune status of rainbow trout (Oncorhynchus n). Aquac Res 51:3674–3684

    Article  CAS  Google Scholar 

  • Babu B, Palanisamy S, Vinosha M, Anjali R, Kumar P, Pandi B, Tabarsa M, You S, Prabhu NM (2020) Bioengineered gold nanoparticles from marine seaweed Acanthophora spicifera for pharmaceutical uses: antioxidant, antibacterial, and anticancer activities. Bioprocess Biosyst Eng 1–12.

  • Balasubramanian G, Sarathi M, Venkatesan C, Thomas J, Hameed AS (2008) Studies on the immunomodulatory effect of extract of Cynodon dactylon in shrimp, Penaeus monodon, and its efficacy to protect the shrimp from white spot syndrome virus (WSSV). Fish Shellfish Immunol 25:820–828

    Article  CAS  PubMed  Google Scholar 

  • Baldissera MD, Souza CF, Zeppenfeld CC, Velho MC, Klein B, Abbad LB, Ourique AF, Wagner R, Da Silva AS, Baldisserotto B (2020) Dietary supplementation with nerolidol nanospheres improves growth, antioxidant status and fillet fatty acid profiles in Nile tilapia: benefits of nanotechnology for fish health and meat quality. Aquaculture 516: 734635.

  • Barman D, Nen P, Mandal SC, Kumar V (2013) Immunostimulants for aquaculture health management. J Mar Sci: Res Develop 3:1

    Google Scholar 

  • Beltrán JMG, Silvera DG, Ruiz CE, Campo V, Chupani L, Faggio C, Esteban MÁ (2020) Effects of dietary Origanum vulgare on gilthead seabream (Sparus aurata L.) immune and antioxidant status. Fish Shellfish Immunol 99:452–461

    Article  CAS  Google Scholar 

  • binti Abang DNJ (2017) In-vitro screening of antioxidant, antibacterial and antifungal properties of herbs for aquaculture. Int J Fish Aquac Stud 5:259–254

    Google Scholar 

  • Bondad-Reantaso MG, Subasinghe RP, Arthur JR, Ogawa K, Chinabut S, Adlard R, Tan Z, Shariff M (2005) Disease and health management in Asian aquaculture. Vet Parasitol 132:249–272

    Article  PubMed  Google Scholar 

  • Capillo G, Savoca S, Costa R, Sanfilippo M, Rizzo C, Lo Giudice A, Albergamo A, Rando R, Bartolomeo G, Spanò N, Faggio C (2018) New insights into the culture method and antibacterial potential of Gracilaria gracilis. Mar Drugs 16:492

    Article  CAS  PubMed Central  Google Scholar 

  • Chakraborty SB, Hancz C (2011) Application of phytochemicals as immunostimulant, antipathogenic and antistress agents in finfish culture. Rev Aquac 3:103–119

    Article  Google Scholar 

  • Chika IB, Onyekachi OJ, Chioma IF, Emmanuel A, Rose ON, Bernard MO (2020) Antiparasiticidal potential of aqueous leaves extract of Moringa oleifera against Ichthyophthirius multifiliis infestation on Clarias gariepinus. J Anim Health pro 8:113–121

    Google Scholar 

  • Citarasu T (2010) Herbal biomedicines: a new opportunity for aquaculture industry. Aquac Int 18:403–414

    Article  Google Scholar 

  • Citarasu T, Sivaram V, Immanuel G, Rout N, Murugan V (2006) Influence of selected Indian immunostimulant herbs against white spot syndrome virus (WSSV) infection in black tiger shrimp, Penaeus monodon with reference to haematological, biochemical and immunological changes. Fish Shellfish Immunol 21:372–384

    Article  PubMed  Google Scholar 

  • Dawood MA, El Basuini MF, Zaineldin AI, Yilmaz S, Hasan M, Ahmadifar E, El Asely AM, Abdel-Latif HM, Alagawany M, Abu-Elala NM, Van Doan H (2021) Antiparasitic and antibacterial functionality of essential oils: an alternative approach for sustainable aquaculture. Pathogens 10(2):185

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • de Castro Nizio DA, Fujimoto RY, Maria AN, Carneiro PCF, França CCS, da Costa SN, de Andrade BF, Sampaio TS, de Fátima A-B, Blank AF (2018) Essential oils of Varronia curassavica accessions have different activity against white spot disease in freshwater fish. Parasitol Res 117:97–105

    Article  PubMed  Google Scholar 

  • dos Santos DS, Majolo C, dos Santos WB, de Oliveira MIB, Farias CFS, Brandão FR, Chagas EC (2021) Anthelmintic activity of eugenol, tannin and thymol against Neoechinorhynchus buttnerae. Arch Veterinary Sci 117–127.

  • El Hajam M, Plavan GI, Kandri NI, Dumitru G, Nicoara MN, Zerouale A, Faggio C (2020) Evaluation of softwood and hardwood sawmill wastes impact on the common carp “Cyprinus carpio” and its aquatic environment: an oxidative stress study. Environ Toxicol Pharmacol. 75: 103327.

  • El-Galil MAA, Aboelhadid SM (2012) Trials for the control of trichodinosis and gyrodactylosis in hatchery reared Oreochromis niloticus fries by using garlic. Vet Parasitol 185(2–4):57–63

    Article  CAS  Google Scholar 

  • Elumalai P, Kurian A, Lakshmi S, Faggio C, Esteban MA, Ringø, E (2020) Herbal immunomodulators in aquaculture. Rev Fish Sci Aquac 1–25.

  • Fu YW, Guo SQ, Luo JJ, Sang CG, Lin DJ, Liu YM, Zhang QZ (2021) Effectiveness assessment of plant mixtures against Ichthyophthirius multifiliis in grass carp Ctenopharyngodon idella. Aquaculture 530: 735742.

  • Hamed H, Ismal S, Faggio C (2020) Effect of allicin on antioxidant defense system, after carbofuran exposure in Nile tilapia, Oreochromis niloticus. Com Bio-Chem Phys C Toxicol Pharmacol 240:108919

  • Hasan MR (2000) Nutrition and feeding for sustainable aquaculture development in the third millennium. In Aquaculture in the third millennium. Technical proceedings of the conference on aquaculture in the third millennium, Bangkok, Thailand, 20:25

  • Hodar AR, Vasava R, Mahavadiya DR, Joshi NH, Nandaniya VV, Solanki HK (2021) Herbs and herbal medicines: A prominent source for sustainable aquaculture. J Experiment Zoo India 24:719–732

    Google Scholar 

  • Hoseinifar SH, Shakouri M, Yousefi S, Van Doan H, Shafiei S, Yousefi M, Mazandarani M, Mozanzadeh T, Tulino MG, Faggio C (2020a) Humoral and skin mucosal immune parameters, intestinal immune related genes expression and antioxidant defense in rainbow trout (Oncorhynchus mykiss) fed olive (Olea europea L.) waste. Fish Shellfish Immunol 100:171–178

    Article  CAS  PubMed  Google Scholar 

  • Hoseinifar SH, Yousefi S, Capillo G, Paknejad H, Khalili M, Tabarraei A, Van Doan H, Spanò N, Faggio C (2018) Mucosal immune parameters, immune and antioxidant defence related genes expression and growth performance of zebrafish (Danio rerio) fed on Gracilaria gracilis powder. Fish Shellfish Immunol 83:232–237

    Article  CAS  PubMed  Google Scholar 

  • Hoseinifar SH, Shakouri M, Yousefi S, Van Doan H, Shafiei S, Yousefi M, Mazandarani M, Torfi MM, Tulino MG, Faggio C (2020b) Humoral and skin mucosal immune parameters, intestinal immune related genes and antioxidant defense of rainbow trout (Oncorhynchus mykiss) fed dietary olive (Olea europea L.) waste. Fish Shellfish Immunol 100:171–178

    Article  CAS  PubMed  Google Scholar 

  • Iswarya A, Vaseeharan B, Anjugam M, Gobi N, Divya M, Faggio C (2018) β-1, 3 glucan binding protein based selenium nanowire enhances the immune status of Cyprinus carpio and protection against Aeromonas hydrophila infection. Fish Shellfish Immunol 83:61–75

    Article  CAS  PubMed  Google Scholar 

  • Jiang HF, Chen C, Jiang XY, Shen JL, Wang T, Li PF, Wang GX (2021) Luteolin in Lonicera japonica inhibits the proliferation of white spot syndrome virus in the crayfish Procambarus clarkii. Aquaculture 737852.

  • Korni FMM, Khalil F (2017) Effect of ginger and its nanoparticles on growth performance, cognition capability, immunity and prevention of motile Aeromonas septicaemia in Cyprinus carpio fingerlings. Aquac Nutr 23:1492–1499

    Article  CAS  Google Scholar 

  • Kumar PV, Pammi SVN, Kollu P, Satyanarayana KVV, Shameem U (2014) Green synthesis and characterization of silver nanoparticles using Boerhaavia diffusa plant extract and their anti bacterial activity. Ind Crop Prod 52:562–566

    Article  CAS  Google Scholar 

  • Kunjiappan, S, Bhattacharjee, C, Chowdhury R (2015) Hepatoprotective and antioxidant effects of Azolla microphylla based gold nanoparticles against acetaminophen induced toxicity in a fresh water common carp fish (Cyprinus carpio L.). Nanomed J. 2 (2): 88–110.

  • Kurian A, Elumalai P (2021b) Study on the impacts of chemical and green synthesized (Leucas aspera and oxy-cyclodextrin complex) dietary zinc oxide nanoparticles in Nile tilapia (Oreochromis niloticus). Environ Sci Pollut Res 1–18.

  • Kurian A, Lakshmi S, Fawole FJ, Faggio C, Elumalai P (2021) Combined effects of Leucas aspera, oxy-cyclodextrin and bentonite on the growth, serum biochemistry, and the expression of immune-related gene in Nile tilapia (Oreochromis niloticus). Turkish J Fish Aquat Sci 21(3):147–158

    Article  Google Scholar 

  • Le Anh DN, Phu TM, Douny C, Quetin-Leclercq J, Hue BTB, Bach LT, Quynh Nhu T, Thi Bich Hang B, Thi Thanh Huong D, Kestemont P (2020) Screening and comparative study of in vitro antioxidant and antimicrobial activities of ethanolic extracts of selected Vietnamese plants. Int J Food Prop 23(1):481–496

    Article  CAS  Google Scholar 

  • Liu M, Yu Q, Xiao H, Li M, Huang Y, Zhang Q, Li P (2020a) The Inhibitory activities and antiviral mechanism of medicinal plant ingredient quercetin against grouper Iridovirus infection. Front Microbiol 11:2457

    Google Scholar 

  • Liu M, Yu Q, Yi Y, Xiao H, Putra DF, Ke K, Zhang Q, Li P (2020a) Antiviral activities of Lonicera japonica Thunb. Components against grouper iridovirus in vitro and in vivo. Aquaculture 519: 734882.

  • Liu YM, Zhang QZ, Xu DH, Fu YW, Lin DJ, Zhou SY (2017) Antiparasitic efficacy of commercial curcumin against Ichthyophthirius multifiliis in grass carp (Ctenopharyngodon idellus). Aquaculture 480:65–70

    Article  CAS  Google Scholar 

  • Luis AI, Campos EV, De Oliveira JL, Guilger-Casagrande M, De Lima R, Castanha RF, De Castro VL, Fraceto LF (2020) Zein nanoparticles impregnated with eugenol and garlic essential oils for treating fish pathogens. ACS Omega 5(25):15557–15566

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mahanty A, Mishra S, Bosu R, Maurya UK, Netam SP, Sarkar B (2013) Phytoextracts-synthesized silver nanoparticles inhibit bacterial fish pathogen Aeromonas hydrophila. Indian J Microbio 53:438–446

    Article  CAS  Google Scholar 

  • Manju S, Malaikozhundan B, Chen JC, Vaseeharan B (2014) Essential oil of Nigella sativa based synthesis of silver nanoparticles and its effect on pathogenic Vibrio harveyi and Vibrio parahaemolyticus isolated from aquatic environments. J Taiwan Fish Soc 41:123–134

    Google Scholar 

  • Manju S, Malaikozhundan B, Vijayakumar S, Shanthi S, Jaishabanu A, Ekambaram P, Vaseeharan B (2016) Antibacterial, antibiofilm and cytotoxic effects of Nigella sativa essential oil coated gold nanoparticles. Microb Pathog 91:129–135

    Article  CAS  PubMed  Google Scholar 

  • Martinez-Porchas M, Martinez-Cordova LR (2012) World aquaculture: environmental impacts and troubleshooting alternatives. Sci World J 1–9.

  • Mehrabi Z, Firouzbakhsh F, Rahimi-Mianji G, Paknejad H (2019) Immunostimulatory effect of Aloe vera (Aloe barbadensis) on non-specific immune response, immune gene expression, and experimental challenge with Saprolegnia parasitica in rainbow trout (Oncorhynchus mykiss). Aquaculture 503:330–338

    Article  CAS  Google Scholar 

  • Muruganandam M, Chipps SR, Ojasvi PR (2019) On the advanced technologies to enhance fisheries production and management. Acta Scientific Agriculture 3(8):216–222

    Article  Google Scholar 

  • Najafi M, Zamini AA (2013) Comparative analysis of antifungal properties of Zataria multiflora Boiss, Eucalyptus spp Essence and Malachite Green on Eggs of Kutum (Rutilus frisii Kutum). Adv Biomed Res 7:163–168

    Google Scholar 

  • Nasr-Eldahan S, Nabil-Adam A, Shreadah MA, Maher AM, Ali TES (2021) A review article on nanotechnology in aquaculture sustainability as a novel tool in fish disease control. Aquac Int 1–22.

  • Nath S, Matozzo V, Bhandari D, Faggio C (2019) Growth and liver histology of Channa punctatus exposed to a common biofertilizer. Nat Prod Res 33:1591–1598

    Article  CAS  PubMed  Google Scholar 

  • Nya EJ, Austin B (2009a) Use of dietary ginger, Zingiber officinale Roscoe, as an immunostimulant to control Aeromonas hydrophila infections in rainbow trout, Oncorhynchus mykiss (Walbaum). J Fish Dis 32:971–977

    Article  CAS  PubMed  Google Scholar 

  • Nya EJ, Austin B (2009b) Use of garlic, Allium sativum, to control Aeromonas hydrophila infection in rainbow trout, Oncorhynchus mykiss (Walbaum). J Fish Dis 32:963–970

    Article  CAS  PubMed  Google Scholar 

  • Pês TS, Saccol EM, Londero ÉP, Bressan CA, Ourique GM, Rizzetti TM, Prestes OD, Zanella R, Baldisserotto B, Pavanato MA (2018) Protective effect of quercetin against oxidative stress induced by oxytetracycline in muscle of silver catfish. Aquaculture 484:120–125

    Article  CAS  Google Scholar 

  • Rashidian G, Bahrami Gorji S, Farsani MN, Prokić MD, Faggio C (2020a) The oak (Quercus brantii) acorn as a growth promoter for rainbow trout (Oncorhynchus mykiss): growth performance, body composition, liver enzymes activity and blood biochemical parameters. Nat Prod Res 34:2413–2423

    Article  CAS  PubMed  Google Scholar 

  • Rashidian G, Kajbaf K, Prokić MD, Faggio C (2020b) Extract of common mallow (Malvae sylvestris) enhances growth, immunity, and resistance of rainbow trout (Oncorhynchus mykiss) fingerlings against Yersinia ruckeri infection. Fish Shellfish Immunol 96:254–261

    Article  CAS  PubMed  Google Scholar 

  • Rashidian G, Boldaji JT, Rainis S, Prokić MD, Faggio C (2021) Oregano (Origanum vulgare) extract enhances zebrafish (Danio rerio) growth performance, serum and mucus innate immune responses and resistance against Aeromonas hydrophila challenge. Animals 11(2):299. https://doi.org/10.3390/ani11020299

    Article  PubMed  PubMed Central  Google Scholar 

  • Rashidian G, Lazado C, Mahboub HH, Mohammadi-Aloucheh R, Prokić M, Nada HS, Faggio C (2021b) Chemically and green synthesized ZnO nanoparticles alter key immunological molecules in common carp (Cyprinus carpio) skin mucus. Int J Mol Sci 22(6):3270. https://doi.org/10.3390/ijms22063270

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Romero J, Feijoó CG, Navarrete P (2012) Antibiotics in aquaculture–use, abuse and alternatives. Health Environ Aquac 159.

  • Rubeena AS, Lakshmi S, George D, Subramaniyan SB, Veerappan A, Preetham E (2020) Shrimp lectin (Md-Lec) conjugated copper sulfide nanoparticles enhance the elimination of aquatic pathogens in infected Nile tilapia (Oreochromis niloticus). RSV Adv 10(72):44216–44224

    Article  CAS  Google Scholar 

  • Saha M, Bandyopadhyay PK (2017) Phytochemical screening for identification of bioactive compound and antiprotozoan activity of fresh garlic bulb over trichodinid ciliates affecting ornamental goldfish. Aquaculture 473:181–190

    Article  CAS  Google Scholar 

  • Seibert CH, Pinto AR (2012) Challenges in shrimp aquaculture due to viral diseases: distribution and biology of the five major penaeid viruses and interventions to avoid viral incidence and dispersion. Braz J Microbiol 43:857–864

    Article  PubMed  PubMed Central  Google Scholar 

  • Shah BR, Mraz J (2020) Advances in nanotechnology for sustainable aquaculture and fisheries. Rev Aquacult 12(2):925–942

  • Shan XF, Kang YH, Bian Y, Gao YH, Wang WL, Qian AD (2014) Isolation of active compounds from methanol extracts of Toddalia asiatica against Ichthyophthirius multifiliis in goldfish (Carassius auratus). Vet Parasitol 199:250–254

    Article  CAS  PubMed  Google Scholar 

  • Sharif Rohani M, Haghighi M, Bazari Moghaddam S (2017) Study on nanoparticles of Aloe vera extract on growth performance, survival rate and body composition in Siberian sturgeon (Acipenser baerii). Iran J Fish Sci 16:457–468

    Google Scholar 

  • Shin SM, Lim JW, Kang SY, Lee MK, Jung SJ (2021) Anti-parasitic effect of lacquer tree Rhus verniciflua Stokes lignum against Miamiensis avidus (Ciliophora: Scuticociliatida). Aquaculture 535:736342

    Article  CAS  Google Scholar 

  • Sinha R, Jindal R, Faggio C (2021a) Nephroprotective effect of Emblica officinalis fruit extract against Malachite Green toxicity in piscine model: ultrastructure and oxidative stress study. Microsc Res Tech. https://doi.org/10.1002/jemt.23747

    Article  PubMed  Google Scholar 

  • Sinha R, Jindal R, Faggio C (2021b) Protective effect of Emblica officinalis in Cyprinus carpio against hepatotoxicity induced by Malachite Green: Ultrastructural and Molecular Analysis. Appl Sci 11(8):3507

    Article  CAS  Google Scholar 

  • Snieszko SF (1974) The effects of environmental stress on outbreaks of infectious diseases of fishes. J Fish Biol 6:197–208

    Article  Google Scholar 

  • Soares BV, Neves LR, Oliveira MSB, Chaves FCM, Dias MKR, Chagas EC, Tavares-Dias M (2016) Antiparasitic activity of the essential oil of Lippia alba on ectoparasites of Colossoma macropomum (tambaqui) and its physiological and histopathological effects. Aquaculture 452:107–114

    Article  CAS  Google Scholar 

  • Souza CF, Baldissera MD, Santos RC, Raffin RP, Baldisserotto B (2017) Nanotechnology improves the therapeutic efficacy of Melaleuca alternifolia essential oil in experimentally infected Rhamdia quelen with Pseudomonas aeruginosa. Aquaculture 473:169–171

    Article  CAS  Google Scholar 

  • Subasinghe R (2009) Disease control in aquaculture and the responsible use of veterinary drugs and vaccines: the issues, prospects and challenges. East Mediterr Health J 86:5–11

    Google Scholar 

  • Sudheer NS, Philip R, Singh IB (2011) In vivo screening of mangrove plants for anti WSSV activity in Penaeus monodon, and evaluation of Ceriops tagal as a potential source of antiviral molecules. Aquaculture 311:36–41

    Article  CAS  Google Scholar 

  • Sun ZC, Chen C, Xu FF, Li BK, Shen JL, Wang T, Jiang HF, Wang GX (2021) Evaluation of the antiviral activity of naringenin, a major constituent of Typha angustifolia, against white spot syndrome virus in crayfish Procambarus clarkii. J Fish Dis 44(10):1503–1513

    Article  CAS  PubMed  Google Scholar 

  • Talpur AD, Ikhwanuddin M (2012) Dietary effects of garlic (Allium sativum) on haemato-immunological parameters, survival, growth, and disease resistance against Vibrio harveyi infection in Asian sea bass, Lates calcarifer (Bloch). Aquaculture 364:6–12

    Article  CAS  Google Scholar 

  • Talpur AD, Ikhwanuddin M (2013) Azadirachta indica (neem) leaf dietary effects on the immunity response and disease resistance of Asian seabass, Lates calcarifer challenged with Vibrio harveyi. Fish Shellfish Immunol 34:254–264

    Article  CAS  PubMed  Google Scholar 

  • Talpur AD, Ikhwanuddin M, Bolong AMA (2013) Nutritional effects of ginger (Zingiber officinale Roscoe) on immune response of Asian sea bass, Lates calcarifer (Bloch) and disease resistance against Vibrio harveyi. Aquaculture 400:46–52

    Article  CAS  Google Scholar 

  • Tu X, Duan C, Wu S, Fu S, Ye J (2021) Identification of plumbagin as an effective chemotherapeutic agent for treatment of Gyrodactylus infections. Aquaculture 535: 736372.

  • Valladão GMR, Gallani SU, Ikefuti CV, Da Cruz C, Levy-Pereira N, Rodrigues MVN, Pilarski F (2016) Essential oils to control ichthyophthiriasis in pacu, Piaractus mesopotamicus (Holmberg): special emphasis on treatment with Melaleuca alternifolia. J Fish Dis 39:1143–1152

    Article  CAS  PubMed  Google Scholar 

  • Van Doan H, Hoseinifar SH, Chitmanat C, Jaturasitha S, Paolucci M, Ashouri G, Dawood MA, Esteban MÁ (2019) The effects of Thai ginseng, Boesenbergia rotunda powder on mucosal and serum immunity, disease resistance, and growth performance of Nile tilapia (Oreochromis niloticus) fingerlings. Aquaculture 513: 734388.

  • Van Doan H, Hoseinifar SH, Faggio C, Chitmanat C, Mai NT, Jaturasitha S, Ringø E (2018) Effects of corncob derived xylooligosaccharide on innate immune response, disease resistance, and growth performance in Nile tilapia (Oreochromis niloticus) fingerlings. Aquaculture 495:786–793

    Article  CAS  Google Scholar 

  • Van Hai N (2015) The use of medicinal plants as immunostimulants in aquaculture: a review. Aquaculture 446:88–96

    Article  CAS  Google Scholar 

  • Vaseeharan B, Thaya R (2014) Medicinal plant derivatives as immunostimulants: an alternative to chemotherapeutics and antibiotics in aquaculture. Aquac Int 22:1079–1091

    Article  CAS  Google Scholar 

  • Vaseeharan B, Sargunar CG, Lin YC, Chen JC (2012) Green synthesis of silver nanoparticles through Calotropis gigantea leaf extracts and evaluation of antibacterial activity against Vibrio alginolyticus. J Nanotechnol 2:e3–e3

    Google Scholar 

  • Vaseeharan B, Sivakamavalli J, Thaya R (2015) Synthesis and characterization of chitosan-ZnO composite and its antibiofilm activity against aquatic bacteria. J Compos Mater 49(2):177–184

  • Vazirzadeh A, Marhamati A, Rabiee R (2020) Immunomodulation, antioxidant enhancement and immune genes up-regulation in rainbow trout (Oncorhynchus mykiss) fed on seaweeds included diets. Fish Shellfish Immunol 106:852–858

    Article  CAS  PubMed  Google Scholar 

  • Vijayakumar S, Vaseeharan B, Sudhakaran R, Jeyakandan J, Ramasamy P, Sonawane A, Padhi A, Velusamy P, Anbu P, Faggio C (2019) Bioinspired zinc oxide nanoparticles using Lycopersicon esculentum for antimicrobial and anticancer applications. J Clust Sci 30:1465–1479

    Article  CAS  Google Scholar 

  • Wang G, Zhou Z, Cheng C, Yao J, Yang Z (2008) Osthol and isopimpinellin from Fructus cnidii for the control of Dactylogyrus intermedius in Carassius auratus. Vet Parasitol 158:144–151

    Article  CAS  PubMed  Google Scholar 

  • Wang GX, Han J, Zhao LW, Jiang DX, Liu YT, Liu XL (2010a) Antihelmintic activity of steroidal saponins from Paris polyphylla. Phytomedicine 17:1102–1105

    Article  CAS  PubMed  Google Scholar 

  • Wang GX, Zhou Z, Jiang DX, Han J, Wang JF, Zhao LW, Li J (2010b) In vivo anthelmintic activity of five alkaloids from Macleaya microcarpa (Maxim) Fedde against Dactylogyrus intermedius in Carassius auratus. Vet Parasitol 171:305–313

    Article  CAS  PubMed  Google Scholar 

  • Wang J, Zhou H, Wang X, Mai K, He G (2019) Effects of silymarin on growth performance, antioxidant capacity and immune response in turbot (Scophthalmus maximus L.). J World Aquac Soc 50(6):1168–1181

    Article  CAS  Google Scholar 

  • Wei L, Wu P, Zhou XQ, Jiang WD, Liu Y, Kuang SY, Tang L, Feng L (2020) Dietary silymarin supplementation enhanced growth performance and improved intestinal apical junctional complex on juvenile grass carp (Ctenopharyngodon idella) Aquaculture 735311.

  • Williams CF, Vacca AR, Dunham L, Lloyd D, Coogan MP, Evans G, Graz M, Cable J (2016) The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens. Mole Biochem Parasitol 206:20–28

    Article  CAS  Google Scholar 

  • Xu Z, Li X, Yang H, Liang G, Gao B, Leng X (2019) Dietary quercetin improved the growth, antioxidation, and flesh quality of grass carp (Ctenopharyngodon idella). J World Aquac Soc 50(6):1182–1195

    Article  CAS  Google Scholar 

  • Yanong RP (2003) Fungal diseases of fish. Vet Clin North Am Exot Anim Pract 6:377–400

    Article  PubMed  Google Scholar 

  • Yanuar E, Sarwana W, Umam K, Huda I, Wijaya D, Roto R, Mudasir M (2020) Green synthesis of silver nanoparticles using Kirinyuh (Chromolaena Odorata) leaf extract and their antibacterial activity against Vibrio sp. In AIP Conference Proceedings (Vol. 2243, No. 1, p. 020031). AIP Publishing LLC.

  • Yavuzcan Yildiz H, Bekcan S (2020) Control of ectoparasitosis in carp (Cyprinus carpio) induced by Gyrodactylus elegans (Monogenea) with garlic (Allium sativum) and onion (Allium cepa) extracts. Ecocycles 6:10–17

    Article  Google Scholar 

  • Yavuzcan Yildiz H, Van Phan Q, Parisi G, Dam Sao M (2019) Anti-parasitic activity of garlic (Allium sativum) and onion (Allium cepa) juice against crustacean parasite, Lernantropus kroyeri, found on European sea bass (Dicentrarchus labrax). Ital J Anim Sci 18:833–837

  • Zhang Q, Xu DH, Klesius PH (2013) Evaluation of an antiparasitic compound extracted from Galla chinensis against fish parasite Ichthyophthirius multifiliis. Vet Parasitol 198:45–53

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

The authors express their sincere thanks to RUSA phase 2.0 grant [ref-24 – 51/2014 – U, Policy] TN. Multi-Gen, Department of Education, Government of India. The authors also would like to thank Ms. Wendy Ruggeri for the English correction.

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Authors and Affiliations

  1. Biomaterials and Biotechnology in Animal Health Lab, Nanobiosciences and Nanopharmacology Division, Department of Animal Health and Management, Alagappa University, Karaikudi, 630004, Tamil Nadu, India

    Jeyaraj Jeyavani, Ashokkumar Sibiya, Mani Divya & Baskaralingam Vaseeharan

  2. Department of Biotechnology and Microbiology, National College (Autonomous), Tamil Nadu, Tiruchirappalli, India

    Jeyachandran Sivakamavalli

  3. Department of Marine Biology, Microbiology and Biochemistry, School of Marine Sciences, Cochin University of Science and Technology (CUSAT), Lakeside Campus Fine Arts Avenue, Cochin, 682 016, Kerala, India

    Elumalai Preetham

  4. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Viale Ferdinando Stagno d’Alcontres, S. Agata, Messina, Italy

    Caterina Faggio

Authors
  1. Jeyaraj Jeyavani
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  2. Ashokkumar Sibiya
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  3. Jeyachandran Sivakamavalli
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  4. Mani Divya
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  5. Elumalai Preetham
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  6. Baskaralingam Vaseeharan
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  7. Caterina Faggio
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Contributions

Jeyavani: Conceptualization, writing and editing; Ashokkumar Sibiya: Data collection, review and formal analysis; Jeyachandran Sivakamavalli: Review and formal analysis; Mani Divya: Data collection, review formal analysis and editing; Elumalai Preetham: Review and editing; Baskaralingam Vaseeharan: Conceptualization, visualization, supervision, validation; Caterina Faggio: Review and formal analysis.

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Correspondence to Baskaralingam Vaseeharan.

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Jeyavani, J., Sibiya, A., Sivakamavalli, J. et al. Phytotherapy and combined nanoformulations as a promising disease management in aquaculture: a review. Aquacult Int 30, 1071–1086 (2022). https://doi.org/10.1007/s10499-022-00848-0

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  • DOI: https://doi.org/10.1007/s10499-022-00848-0

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