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Behavioral, Hormonal, and Neurotransmitter Reactions to Stress in Adult Rats with a History of High IL-1β Content in the Early Postnatal Ontogeny

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Bulletin of Experimental Biology and Medicine Aims and scope

Behavioral, hormonal, and neurotransmitter reactions to foot shock were studied in adult rats treated with IL-1β during week 3 of life. After stress, these animals differed from controls treated with saline by high levels of dopamine, serotonin, and 5-hydroxy-indolacetic acid in the hypothalamus. In contrast to controls, they developed a significant stress-induced increase of blood corticosterone level and exhibited lesser motor and exploratory activities in the open field test.

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Authors and Affiliations

  1. Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia

    O. E. Zubareva, A. P. Schwartz, L. K. Khnychenko & V. M. Klimenko

  2. State Research Institute of Extrapure Biopreparations, Federal Biomedical Agency of Russia, St. Petersburg, Russia

    A. M. Ishchenko & A. S. Simbirtsev

Authors
  1. O. E. Zubareva
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  2. A. P. Schwartz
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  3. L. K. Khnychenko
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  4. A. M. Ishchenko
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  5. A. S. Simbirtsev
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  6. V. M. Klimenko
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Corresponding author

Correspondence to O. E. Zubareva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 11, pp. 552-556, November, 2014

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Zubareva, O.E., Schwartz, A.P., Khnychenko, L.K. et al. Behavioral, Hormonal, and Neurotransmitter Reactions to Stress in Adult Rats with a History of High IL-1β Content in the Early Postnatal Ontogeny. Bull Exp Biol Med 158, 607–610 (2015). https://doi.org/10.1007/s10517-015-2817-9

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  • DOI: https://doi.org/10.1007/s10517-015-2817-9

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