Skip to main content
Log in

Depressive Behavior and Monoamine Contents in Brain Structures of Rats During Chronic Overcrowding

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Effects of chronic overcrowding on the development of depressive-like behavior and changes in monoamine contents in the brain structures involved in the development of depression were studied in rats. It was shown that overcrowding increased grooming duration and did not change the number of crossed squares and postures in the open-field test. In the forced swimming test, overcrowding increased immobility time and deceased the duration of the first episode of active swimming, which attested to depressive-like behavior. Overcrowding reduced the content of dopamine in the striatum, its metabolites (homovanilic and dioxyphenylacetic acids) and dopamine metabolism rate in the hypothalamus, and increased the concentrations of norepinephrine, homovanilic acid, and dioxyphenylacetic acid in the olfactory bulb and homovanilic acid in the prefrontal cortex. No changes were found in the nucleus accumbens. Serotonin content did not change in all analyzed structures. It was hypothesized that the observed changes in the content of monoamines and their metabolites in certain brain structures could underlie the depressive-like behavior induced by overcrowding in rats.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. I. Knyazeva, N. A. Loginova, and E. V. Loseva, Bull. Exp. Biol. Med., 154, No. 1, 3-6 (2012).

    Article  CAS  PubMed  Google Scholar 

  2. E. V. Loseva, N. A. Loginova, M. V. Mezentseva, et al., Bull. Exp. Biol. Med., 155, No. 4, 470-473 (2013).

    Article  CAS  PubMed  Google Scholar 

  3. E. V. Loseva, N. V. Pasikova, N. A. Loginova, et al., Zh. Vyssh. Nervn. Deyat., 57, No. 3, 323-325 (2007).

    CAS  Google Scholar 

  4. Yu. V. Moiseeva, N. M. Khonicheva, M. G. Airapetyants, et al., Neirokhimiya, No. 1, 64-71 (2009).

  5. K. Yu. Sarkisova, M. A. Kulikov, V. S. Kudrin, et al., Zh. Vyssh. Nervn. Deyat., 63, No. 3, 303 (2013).

  6. W. M. Daniels, C. Y. Pietersen, M. E. Carstens, et al., Metab. Brain Dis., 15, No. 4, 287-295 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. M. Kivimäki, J. Vahtera, I. Kawachi, et al., Am. J. Epidemiol., 172, No. 2, 167-172 (2010).

    Article  PubMed Central  PubMed  Google Scholar 

  8. D. A. Morilak and A. Frazer, Int. J. Neuropsychopharmacol., 7, No. 2, 193-218 (2004).

    Article  CAS  PubMed  Google Scholar 

  9. H. Naitoh, S. Nomura, Y. Kunimi, and K. Yamaoka, Keio J. Med., 41, No. 4, 221-224 (1992).

    Article  CAS  PubMed  Google Scholar 

  10. E. Palazidou, Br. Med. Bull., 101, 127-145 (2012).

    Article  CAS  PubMed  Google Scholar 

  11. H. Sadowski, B. Ugarte, I. Kolvin, et al., Br. J. Psychiatry., 174, 112-120 (1999).

    Article  CAS  PubMed  Google Scholar 

  12. K. Y. Sarkisova, I. S. Midzianovskaia, and M. A. Kulikov, Behav. Brain Res., 144, Nos. 1-2, 211-226 (2003).

    Article  CAS  PubMed  Google Scholar 

  13. T. P. Sheehan, R. A. Chambers, and D. S. Russell, Brain Res. Brain Res. Rev., 46, No. 1, 71-117 (2004).

    Article  PubMed  Google Scholar 

  14. P. C. Sprivulis, J. A. Da Silva, I. G. Jacobs, et al., Med. J. Aust., 184, No. 5, 208-212 (2006).

    PubMed  Google Scholar 

  15. I. Toth and I. D. Neumann, Cell Tissue Res., 354, No. 1, 107-118 (2013).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to E. V. Loseva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 304-307, March, 2015

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Loseva, E.V., Sarkisova, K.Y., Loginova, N.A. et al. Depressive Behavior and Monoamine Contents in Brain Structures of Rats During Chronic Overcrowding. Bull Exp Biol Med 159, 327–330 (2015). https://doi.org/10.1007/s10517-015-2953-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-015-2953-2

Key Words

Navigation