Effects of chronic overcrowding on the development of depressive-like behavior and changes in monoamine contents in the brain structures involved in the development of depression were studied in rats. It was shown that overcrowding increased grooming duration and did not change the number of crossed squares and postures in the open-field test. In the forced swimming test, overcrowding increased immobility time and deceased the duration of the first episode of active swimming, which attested to depressive-like behavior. Overcrowding reduced the content of dopamine in the striatum, its metabolites (homovanilic and dioxyphenylacetic acids) and dopamine metabolism rate in the hypothalamus, and increased the concentrations of norepinephrine, homovanilic acid, and dioxyphenylacetic acid in the olfactory bulb and homovanilic acid in the prefrontal cortex. No changes were found in the nucleus accumbens. Serotonin content did not change in all analyzed structures. It was hypothesized that the observed changes in the content of monoamines and their metabolites in certain brain structures could underlie the depressive-like behavior induced by overcrowding in rats.
Similar content being viewed by others
References
S. I. Knyazeva, N. A. Loginova, and E. V. Loseva, Bull. Exp. Biol. Med., 154, No. 1, 3-6 (2012).
E. V. Loseva, N. A. Loginova, M. V. Mezentseva, et al., Bull. Exp. Biol. Med., 155, No. 4, 470-473 (2013).
E. V. Loseva, N. V. Pasikova, N. A. Loginova, et al., Zh. Vyssh. Nervn. Deyat., 57, No. 3, 323-325 (2007).
Yu. V. Moiseeva, N. M. Khonicheva, M. G. Airapetyants, et al., Neirokhimiya, No. 1, 64-71 (2009).
K. Yu. Sarkisova, M. A. Kulikov, V. S. Kudrin, et al., Zh. Vyssh. Nervn. Deyat., 63, No. 3, 303 (2013).
W. M. Daniels, C. Y. Pietersen, M. E. Carstens, et al., Metab. Brain Dis., 15, No. 4, 287-295 (2000).
M. Kivimäki, J. Vahtera, I. Kawachi, et al., Am. J. Epidemiol., 172, No. 2, 167-172 (2010).
D. A. Morilak and A. Frazer, Int. J. Neuropsychopharmacol., 7, No. 2, 193-218 (2004).
H. Naitoh, S. Nomura, Y. Kunimi, and K. Yamaoka, Keio J. Med., 41, No. 4, 221-224 (1992).
E. Palazidou, Br. Med. Bull., 101, 127-145 (2012).
H. Sadowski, B. Ugarte, I. Kolvin, et al., Br. J. Psychiatry., 174, 112-120 (1999).
K. Y. Sarkisova, I. S. Midzianovskaia, and M. A. Kulikov, Behav. Brain Res., 144, Nos. 1-2, 211-226 (2003).
T. P. Sheehan, R. A. Chambers, and D. S. Russell, Brain Res. Brain Res. Rev., 46, No. 1, 71-117 (2004).
P. C. Sprivulis, J. A. Da Silva, I. G. Jacobs, et al., Med. J. Aust., 184, No. 5, 208-212 (2006).
I. Toth and I. D. Neumann, Cell Tissue Res., 354, No. 1, 107-118 (2013).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 304-307, March, 2015
Rights and permissions
About this article
Cite this article
Loseva, E.V., Sarkisova, K.Y., Loginova, N.A. et al. Depressive Behavior and Monoamine Contents in Brain Structures of Rats During Chronic Overcrowding. Bull Exp Biol Med 159, 327–330 (2015). https://doi.org/10.1007/s10517-015-2953-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-015-2953-2