We studied the effect of gonadotropin-releasing hormone agonist surfagon (2 μg/kg, once, intraperitoneally) on anxious behavior of adult gonadectomized and non-gonadectomized male rats. It was shown that surfagon significantly increased anxiety of both gonadectomized and non-gonadectomized rats in the open-field test and in elevated plus maze
Similar content being viewed by others
References
Bureš J, Burešová O, Huston JP. Techniques and Basic Experiments for the Study of Brain and Behavior. Moscow, 1991 Russian.
Alfimtsev VN, Alfimtsev NA, Bukreev JM, Kuzin VS. Patent RU No. 2428144. Method to stimulate reproductive function in animals. Bull. No. 25. Published September 10, 2011.
Burnham V, Sundby C, Laman-Maharg A, Thornton J. Luteinizing hormone acts at the hippocampus to dampen spatial memory. Horm. Behav. 2017;89:55-63.
Chu C, Gao G, Huang W. A study on co-localization of FSH and its receptor in rat hippocampus. J. Mol. Histol. 2008; 39(1):49-55.
Jennes L, Brame B, Centers A, Janovick JA, Conn PM. Regulation of hippocampal gonadotropin releasing hormone (GnRH) receptor mRNA and GnRH-stimulated inositol phosphate production by gonadal steroid hormones. Brain Res. Mol. Brain. Res. 1995;33(1):104-110
Morote J, Tabernero ÁJ, Álvarez-Ossorio JL, Ciria JP, Domínguez- Escrig JL, Vázquez F, Angulo J, López FJ, de La Iglesia R, Romero J. Cognitive function in patients on androgen suppression: A prospective, multicentric study. Actas Urol. Esp. 2017;42(2):114-120.
Sagsöz N, Oguztürk O, Bayram M, Kamaci M. Anxiety and depression before and after the menopause. Arch. Gynecol. Obstet. 2001;264(4):199-202.9. Seidman S.N. Testosterone deficiency and mood in aging men: pathogenic and therapeutic interactions. World J. Biol. Psychiatry. 2003;4(1):14-20.
Seidman SN. Testosterone deficiency and mood in aging men: pathogenic and therapeutic interactions. World J. Biol. Psychiatry. 2003;4(1):14-20.
Suarez-Jimenez B, Gore HE, Hachey J, King HM, Lacreuse A. Testosterone modulation of anxiety in gonadally-suppressed male rhesus monkeys: a role for gonadotropins? Pharmacol. Biochem. Behav. 2013;104:97-104.
Wiechno PJ, Sadowska M, Kalinowski T, Michalski W, Demkow T. Does pharmacological castration as adjuvant therapy for prostate cancer after radiotherapy affect anxiety and depression levels, cognitive functions and quality of life? Psychooncology. 2013;22(2):346-351.
Wilson AC, Salamat MS, Haasl RJ, Roche KM, Karande A, Meethal SV, Terasawa E, Bowen RL, Atwood CS. Human neurons express type I GnRH receptor and respond to GnRH I by increasing luteinizing hormone expression. J. Endocrinol. 2006;191(3):651-663
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 7, pp. 60-62, July, 2019
Rights and permissions
About this article
Cite this article
Masalova, O.O., Kazakova, S.B., Savateeva-Lyubimova, T.N. et al. Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats. Bull Exp Biol Med 168, 52–54 (2019). https://doi.org/10.1007/s10517-019-04644-4
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-019-04644-4