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Host-imposed manganese starvation of invading pathogens: two routes to the same destination

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Abstract

During infection invading pathogens must acquire all essential nutrients, including first row transition metals, from the host. To combat invaders, the host exploits this fact and restricts the availability of these nutrients using a defense mechanism known as nutritional immunity. While iron sequestration is the most well-known aspect of this defense, recent work has revealed that the host restricts the availability of other essential elements, notably manganese (Mn), during infection. Furthermore, these studies have revealed that the host utilizes multiple strategies that extend beyond metal sequestration to prevent bacteria from obtaining these metals. This review will discuss the mechanisms by which bacteria attempt to obtain the essential first row transition metal ion Mn during infection, and the approaches utilized by the host to prevent this occurrence. In addition, this review will discuss the impact of host-imposed Mn starvation on invading bacteria.

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Acknowledgments

We apologize to our colleagues whose work we were unable to cite due to length restrictions. J.R.M. is supported by an Australian Postgraduate Award. This work was supported by the Australian Research Council Grants DP120103957 and DP150104515 to C.A.M., the National Health and Medical Research Council Project Grants 1022240 and 1080784 to C.A.M., and a K22 AI104805 from the National Institutes of Health as well as by Research Grant No. 5-FY15-30 from the March of Dimes Foundation to T.E.K. This work is solely the responsibility of the authors and does not reflect the views of the National Institutes of Health.

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The authors declare no competing financial interests.

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  1. Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA, 5005, Australia

    Jacqueline R. Morey & Christopher A. McDevitt

  2. Department of Microbiology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA

    Thomas E. Kehl-Fie

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  1. Jacqueline R. Morey
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  2. Christopher A. McDevitt
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  3. Thomas E. Kehl-Fie
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Correspondence to Christopher A. McDevitt or Thomas E. Kehl-Fie.

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Morey, J.R., McDevitt, C.A. & Kehl-Fie, T.E. Host-imposed manganese starvation of invading pathogens: two routes to the same destination. Biometals 28, 509–519 (2015). https://doi.org/10.1007/s10534-015-9850-z

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