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Metal and metalloid containing natural products and a brief overview of their applications in biology, biotechnology and biomedicine

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Abstract

Bioinorganic natural product chemistry is a relatively unexplored but rapidly developing field with enormous potential for applications in biology, biotechnology (especially in regards to nanomaterial development, synthesis and environmental cleanup) and biomedicine. In this review the occurrence of metals and metalloids in natural products and their synthetic derivatives are reviewed. A broad overview of the area is provided followed by a discussion on the more common metals and metalloids found in natural sources, and an overview of the requirements for future research. Special attention is given to metal hyperaccumulating plants and their use in chemical synthesis and bioremediation, as well as the potential uses of metals and metalloids as therapeutic agents. The potential future applications and development in the field are also discussed.

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References

  • Adeyemi AO, Gadd GM (2005) Fungal degradation of calcium-, lead- and silicon-bearing minerals. Biometals 18:269–281

    Article  CAS  PubMed  Google Scholar 

  • Ang WH, Casini A, Sava G, Dyson PJ (2011) Organometallic ruthenium-based antitumor compounds with novel modes of action. J Organomet Chem 696:989–998

    Article  CAS  Google Scholar 

  • Baker MV, Barnard PJ, Berners-Price SJ, Brayshaw SK, Hickey JL, Skelton BW, White AH (2006) Cationic, linear Au(I) N-heterocyclic carbene complexes: synthesis, structure and anti-mitochondrial activity. Dalton Trans 14:3708–3715

    Article  CAS  Google Scholar 

  • Banker R, Carmeli S (1998) Tenuecyclamides A–D, cyclic hexapeptides from the cyanobacterium Nostoc spongiaeforme var. tenue. J Nat Prod 61:1248–1251

    Article  CAS  PubMed  Google Scholar 

  • Beers C, Mousavi A (2013) Mercury speciation and safety evaluation of cinnabar-containing traditional medicines: a mini-review. Toxicol Environ Chem 95:207–213

    Article  CAS  Google Scholar 

  • Bertrand B, Casini A (2014) A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds. Dalton Trans 43:4209–4219

    Article  CAS  PubMed  Google Scholar 

  • Bird ML, Challenger F, Charlton PT, Smith JO (1948) Studies on biological methylation. 11. The action of moulds on inogranic compounds of arsenic. Biochem J 43:78–83

    Article  PubMed Central  CAS  Google Scholar 

  • Blisard KS, Harrington DA, Long DA, Jackson JE (1991) Relative lack of toxicity of transplatin compared with cisplatin in rodents. J Comp Pathol 105:367–375

    Article  CAS  PubMed  Google Scholar 

  • Boriova K, Cernansky S, Matus P, Bujdos M, Simonovicova A (2014) Bioaccumulation and biovolatilization of various elements using filamentous fungus Scopulariopsis brevicaulis. Lett Appl Microbiol 59:217–223

    Article  CAS  PubMed  Google Scholar 

  • Bouriche H, Meziti H, Senator A, Arnhold J (2011) Anti-inflammatory, free radical-scavenging, and metal-chelating activities of Malva parviflora. Pharm Biol 49:942–946

    Article  CAS  PubMed  Google Scholar 

  • Brown SD, Nativo P, Smith J-A, Stirling D, Edwards PR, Venugopal B, Flint DJ, Plumb JA, Graham D, Wheate NJ (2010) Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. J Am Chem Soc 132:4678–4684

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Bruijnincx PCA, Sadler PJ (2009) Controlling platinum, ruthenium and osmium reactivity for anticancer drug design. Adv Inorg Chem 61:1–62

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Byrne AR, Tusek-Znidaric M, Puri BK, Irgolic KJ (1991) Studies on the uptake and binding of trace metals in fungi. Part II: Arsenic compounds in Laccaria amethystina. Appl Organomet Chem 5:25

    Article  CAS  Google Scholar 

  • Byrne AR, Šlejkovec Z, Stijve T, Fay L, Gössler W, Gailer J, Lrgolic KJ (1995) Arsenobetaine and other arsenic species in mushrooms. Appl Organomet Chem 9:305–313

    Article  CAS  Google Scholar 

  • Calvert CC, Smith LW (1980) Arsenic in tissues of sheep and milk of dairy cows fed arsanilic acid and 3-nitro-4-hydroxyphenylarsonic acid. J Anim Sci 51:414–421

    CAS  PubMed  Google Scholar 

  • Cases J, Vacchina V, Napolitano A, Caporiccio B, Besançon P, Lobinski R, Rouanet JM (2001) Selenium from selenium-rich Spirulina is less bioavailable than selenium from sodium selenite and selenomethionine in selenium-deficient rats. J Nutr 9:2343–2350

    Google Scholar 

  • Casini A, Reedijk J (2012) Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry? Chem Sci 3:3135–3144

    Article  CAS  Google Scholar 

  • Ceresia GB, Brusch CA (1955) An introduction to the history of medicinal chemistry. Am J Pharm Sci Support Public Health 127:384–395

    CAS  PubMed  Google Scholar 

  • Chakraborty P, Ramteke D, Chakraborty S, Nagender Nath B (2014) Mar Pollut Bull. Changes in metal contamination levels in estuarine sediments around India—an assessment 78:15–25

    CAS  Google Scholar 

  • Chasteen TG, Bentley R (2002) Biomethylation of selenium and tellurium: microorganisms and plants. Chem Rev 103:1–26

    Article  CAS  Google Scholar 

  • Corbi PP, Quintão FA, Ferraresi DKD, Lustri WR, Amaral AC, Massabni AC (2010) Chemical, spectroscopic characterization, and in vitro antibacterial studies of a new gold(I) complex with N-acetyl-l-cysteine. J Coord Chem 63:1390–1397

    Article  CAS  Google Scholar 

  • Cullen WR (2008) Is arsenic an aphrodisiac? The sociochemistry of an element. The Royal Society of Chemistry, Cambridge, pp 1–412

    Book  Google Scholar 

  • David B, Wolfender J-L, Dias D (2015) The pharmaceutical industry and natural products: historical status and new trends. Phytochemistry Rev 14:299–315

    Article  CAS  Google Scholar 

  • deMorais MG, Vaz Bda S, de Morais EG and Costa JA (2015) Biologically Active Metabolites Synthesized by Microalgae. BioMed Res Int 2015:Epub 2015 Aug 3

  • Dias D, Urban S, Roessner U (2012) A Historical Overview of Natural Products in Drug Discovery. Metabolites 2:303–336

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Dimise EJ, Condurso HL, Stokera GE, Bruner SD (2012) Synthesis and structure confirmation of fuscachelins A and B, structurally unique natural product siderophores from Thermobifida fusca. Org Biomol Chem 10:5353

    Article  CAS  PubMed  Google Scholar 

  • Dollwet HHA and Sorenson JRJ (1985) Historic uses of copper compounds in medicine. J Trace Elem Med Bio 2:80–87

    Google Scholar 

  • Dutta S, Snyder MJ, Rosile D, Binz KL, Roll EH, Suryadi J, Bierbach U, Guthold M (2013) PT-ACRAMTU, a platinum-acridine anticancer agent, lengthens and aggregates, but does not stiffen or soften DNA. Cell Biochem Biophys 67:1103–1113

    Article  CAS  PubMed  Google Scholar 

  • Edmonds JS, Morita M, Shibata Y (1987) Isolation and identification of arsenic-containing ribofuranosides and inorganic arsenic from Japanese edible seaweed hizikia fusiforme. J Chem Soc Perkin Trans I:577–580

    Article  Google Scholar 

  • Eiter LC, Hall NW, Day CS, Saluta G, Kucera GL, Bierbach U (2009) Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against mycobacterium tuberculosis. J Med Chem 52:6519–6522

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Elshahawi SI, Trindade-Silva AE, Hanora A, Han AW, Flores MS, Vizzoni V, Schrago CG, Soares CA, Concepcion GP, Distel DL, Schmidt EW, Haygood MG (2013) Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills. Proc Natl Acad Sci USA 110:E295–E304

    Article  PubMed Central  PubMed  Google Scholar 

  • Escande V, Renard BL, Grison C (2015) Lewis acid catalysis and Green oxidations: sequential tandem oxidation processes induced by Mn-hyperaccumulating plants. Environ Sci Pollut Res Int 22:5633–5652

    Article  CAS  PubMed  Google Scholar 

  • FDA (2011) FDA response to citizen petition on arsenic-based animal drugs. U.S. Food and Drug Administration. http://www.fda.gov/. Accessed 10 Feb 2015

  • Fransisca Y, Small DM, Morrison PD, Spencer MJ, Ball AS, Jones OA (2015) Assessment of arsenic in Australian grown and imported rice varieties on sale in Australia and potential links with irrigation practises and soil geochemistry. Chemosphere 138:1008–10013

    Article  CAS  PubMed  Google Scholar 

  • Gao J-P, Chao D-Y, Lin H-X (2007) Understanding abiotic stress tolerance mechanisms: recent studies on stress response in rice. J Integr Plant Biol 49:742–750

    Article  CAS  Google Scholar 

  • Geldenhuys WJ, Van Der Schyf CJ (2013) Rationally designed multi-targeted agents against neurodegenerative diseases. Curr Med Chem 20:1662–1672

    Article  CAS  PubMed  Google Scholar 

  • Graham LA, Wilson GM, West TK, Day CS, Kucera GL, Bierbach U (2011) Unusual reactivity of a potent platinum-acridine hybrid antitumor agent. ACS Med Chem Lett 2:687–691

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Greene ME (2008) Understanding biosilification: biomaterials. Mater Today 11:8

    Google Scholar 

  • Grison C, Escande V, Petit E, Garoux L, Boulanger C, Grison C (2013) Psychotria douarrei and Geissois pruinosa, novel resources for the plant-based catalytic chemistry. RSC Adv 3:22340–22345

    Article  CAS  Google Scholar 

  • Groudev SN, Spasova II, Ivanov IM (1996) Two-stage microbial leaching of a refractory gold-bearing pyrite ore. Miner Eng 9:707–713

    Article  CAS  Google Scholar 

  • Grümping R, Michalke K, Hirner AV, Hensel R (1999) Microbial degradation of octamethylcyclotetrasiloxane. Appl Environ Microb 65:2276–2278

    Google Scholar 

  • Han G, Ghosh P, Rotello VM (2007) Functionalized gold nanoparticles for drug delivery. Nanomedicine-UK 2:113–123

    Article  CAS  Google Scholar 

  • Hanson LE, Hill EG, Ferrin EF (1956) The comparative value of antibiotics and arsonic acids for growing pigs. J Anim Sci 15:280–287

    CAS  Google Scholar 

  • Hashimoto H, Itadani A, Kudoh T, Fukui S, Kuroda Y, Seno M, Kusano Y, Ikeda Y, Benino Y, Nanba T, Nakanishi M, Fujii T, Takada J (2013) Nano-micrometer-architectural acidic silica prepared from iron oxide of leptothrix ochracea origin. ACS Appl Mater Interfaces 5:5194–5200

    Article  CAS  PubMed  Google Scholar 

  • Hemscheidt T, Puglisi MP, Larsen LK, Patterson GML, Moore RE (1994) Structure and biosynthesis of borophycin, a new boeseken complex of boric acid from a marine strain of the blue-green alga Nostoc linckia. J Org Chem 59:3467–3471

    Article  CAS  Google Scholar 

  • Henstock JR, Canham LT, Anderson SI (2015) Silicon: the evolution of its use in biomaterials. Acta Biomater 11:17–26

    Article  CAS  PubMed  Google Scholar 

  • Honschopp S, Brunken N, Nehrkorn A, Breunig HJ (1996) Isolation and characterization of a new arsenic methylating bacterium from soil. Microbiol Res 151:37–41

    Article  CAS  PubMed  Google Scholar 

  • Hutter R, Keller-Schierlein W, Knusel F, Prelog V, Rodgers Jr GC, Suter P, Vogel G, Voser W, Zahner H (1967) Stoffwechselprodukte von Mikroorganismen. Helv Chim Acta 50:1533–1539

    Article  CAS  PubMed  Google Scholar 

  • Ikeda S, Ishino S, Harada T, Okamoto N, Sakata T, Mori H, Kuwabata S, Torimoto T, Matsumura M (2006) Ligand-free platinum nanoparticles encapsulated in a hollow porous carbon shell as a highly active heterogeneous hydrogenation catalyst. Angew Chem Int Ed 45:7063–7066

    Article  CAS  Google Scholar 

  • Irschik H, Schummer D, Gerth K, Hofle G, Reichenbach H (1995) Tartrolons, new boron-containing antibiotics from a myxobacterium, Sorangium cellulosum. J Antibiot 48:26–30

    Article  CAS  PubMed  Google Scholar 

  • Islam ASM, Fukushi K, Yamamoto K (2005) Development of an enumeration method for arsenic methylating bacteria from mixed culture samples. Biotechnol Lett 27:1885–1890

    Article  CAS  PubMed  Google Scholar 

  • Jaffre T, Brooks RR, Trow JM (1979) Hyperaccumulation of nickel by Geissois species. Plant Soil 51:157–161

    Article  CAS  Google Scholar 

  • Jerez CA, Moo-Young M (2011) Bioleaching and biomining for the industrial recovery of metals. In: Comprehensive biotechnology, 2nd edn. Academic Press, Burlington, pp 717–729

  • Kelly PC, Brooks RR, Dilli S, Jaffré T (1975) Preliminary observations on the ecology and plant chemistry of some nickel-accumulating plants from New Caledonia. Proc Roy Soc Lond B 189:69–80

    Article  CAS  Google Scholar 

  • Kloss F, Pidot S, Goerls H, Friedich T, Hertweck C (2013) Formation of a dinuclear copper(I) complex from the clostridium-derived antibiotic closthioamide. Angew Chem Int Ed Engl 52:10745–10748

    Article  CAS  PubMed  Google Scholar 

  • Koch R (1890) Über bakteriologische forschung. Deutsche Med Wochenschrift 16:756–757

    Google Scholar 

  • Kohno J, Kawahata T, Otake T, Morimoto M, Mori H, Ueba N, Nishio M, Kinumaki A, Komatsubara S, Kawashima K (1996) Boromycin, an anti-HIV antibiotic. Biosci Biotechnol Biochem 60:1036–1037

    Article  CAS  PubMed  Google Scholar 

  • Krämer U (2010) Metal hyperaccumulation in plants. Annu Rev Plant Biol 61:517–534

    Article  CAS  PubMed  Google Scholar 

  • Kuehnelt D, Lintschinger J, Goessler W (2000) Arsenic compounds in terrestrial organisms. IV. Green plants and lichens from an old arsenic smelter site in Austria. Appl Organomet Chem 14:411–420

    Article  CAS  Google Scholar 

  • Kumar KS, Dahms H-U, Won W-J, Lee J-S, Shin K-H (2015) Microalgae—a promising tool for heavy metal remediation. Ecotox Environ Safe 113:329–352

    Article  CAS  Google Scholar 

  • Lamottke K, Ripoll C, Walczak R (2011) The roots of innovation. EBR 15:52–56

    Google Scholar 

  • Lansdown ABG (2014) The carcinogenicity of metals: human risk through occupational and environmental exposure. R Soc Chem Book 18:1–448

    Google Scholar 

  • Lehmann RG, Miller JR, Kozerski GE (2000) Degradation of silicone polymer in a field soil under natural conditions. Chemosphere 41:743–749

    Article  CAS  PubMed  Google Scholar 

  • Lerch M, Ressler T, Krumeich F, Cosson J-P, Hnawia E, Grohmann A (2010) Carbon-supported nickel nanoparticles from a wood sample of the tree Sebertia acuminata Pierre ex. Baillon. Aust J Chem 63:830–835

    Article  CAS  Google Scholar 

  • Lewer P, Chapin EL, Graupner PR, Gilbert JR, Peacock C (2003) Tartrolone C: a novel insecticidal macrodiolide produced by Streptomyces sp. CP1130. J Nat Prod 66:143–145

    Article  CAS  PubMed  Google Scholar 

  • Li J, Liu Y, Cheng JJ, Mos M, Daroch M (2015) Biological potential of microalgae in China for biorefinery-based production of biofuels and high value compounds. New Biotechnol 32:588–596

    Article  CAS  Google Scholar 

  • Lutz TG, Clevette DJ, Rettig SJ, Orvig C (1989) Metal chelation with natural products: isomaltol complexes of aluminum, gallium, and indium. Inorg Chem 28:715–719

    Article  CAS  Google Scholar 

  • Marchiol L, Mattiello A, Poscic F, Giordano C, Musetti R (2014) In vivo synthesis of nanomaterials in plants: location of silver nanoparticles and plant metabolism. Nanoscale Res Lett 9:101

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Martins ET, Baruah H, Kramarczyk J, Saluta G, Day CS, Kucera GL, Bierbach U (2001) Design, synthesis, and biological activity of a novel non-cisplatin-type platinum-acridine pharmacophore. J Med Chem 44:4492–4496

    Article  CAS  PubMed  Google Scholar 

  • McMaster H (2013) Unlocking the potential of resveratrol in the battle against bowel cancer—see more at: http://www.thecitizen.org.au/features/wine-0#sthash.Jjdvjcaw.dpuf. Accessed 27 Oct 2015

  • Meyer J, Schmidt A, Michalke K, Hensel R (2006) Volatilisation of metals and metalloids by the microbial population of an alluvial soil. Syst Appl Microbiol 30:229–238

    Article  CAS  PubMed  Google Scholar 

  • Mishra BB, Tiwari VK (2011) Natural products: an evolving role in future drug discovery. Euro J Med Chem 46:4769–4807

    Article  CAS  Google Scholar 

  • Mjos KD, Orvig C (2014) Metallodrugs in medicinal inorganic chemistry. Chem Rev 114:4540–4563

    Article  CAS  PubMed  Google Scholar 

  • Muckter H, Liebl B, Reichl FX, Hunder G, Walther U, Fichtl B (1997) Are we ready to replace dimercaprol (BAL) as an arsenic antidote? Hum Exp Toxicol 16:460–465

    Article  CAS  PubMed  Google Scholar 

  • Okazaki T, Kitahara T, Okami Y (1975) Studies on marine microorganisms. IV. A new antibiotic SS-228 Y produced by Chainia isolated from shallow sea mud. J Antibiot 28:176–184

    Article  CAS  PubMed  Google Scholar 

  • Ollivier PRL, Bahrou AS, Marcus S, Cox T, Church TM, Hanson TE (2008) Volatilization and precipitation of tellurium by aerobic, tellurite-resistant marine microbes. Appl Environ Microb 74:7163–7173

    Article  CAS  Google Scholar 

  • Ollivier PRL, Bahrou AS, Church TM, Hanson TE (2011) Aeration controls the reduction and methylation of tellurium by the aerobic, tellurite-resistant marine yeast rhodotorula mucilaginosa. Appl Environ Microb 77:4610–4617

    Article  CAS  Google Scholar 

  • Orvig C, Abrams MJ (1999) Medicinal inorganic chemistry: introduction. Chem Rev 99:2201–2204

    Article  CAS  PubMed  Google Scholar 

  • Ott I, Qian X, Xu Y, Vlecken DH, Marques IJ, Kubutat D, Will J, Sheldrick WS, Jesse P, Prokop A, Bagowski CP (2009) A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor. J Med Chem 52:763–770

    Article  CAS  PubMed  Google Scholar 

  • Pillai MS, Latha SP (2012) Designing of some novel metallo antibiotics tuning biochemical behaviour towards therapeutics: synthesis, characterisation and pharmacological studies of metal complexes of cefixime. J Saudi Chem Soc. doi:10.1016/j.jscs.2012.09.004

    Google Scholar 

  • Qin S, Lin HZ, Jiang P (2012) Advances in genetic engineering of marine algae. Biotechnol Adv 30:1602–1613

    Article  CAS  PubMed  Google Scholar 

  • Rahman MA, Hasegawa H, Lim RP (2012) Bioaccumulation, biotransformation and trophic transfer of arsenic in the aquatic food chain. Environ Res 116:118–135

    Article  CAS  PubMed  Google Scholar 

  • Rezanka T, Sigler K (2008) Biologically active compounds of semi-metals. Phytochemistry 69:585–606

    Article  CAS  PubMed  Google Scholar 

  • Rosenberg B, Vancamp L, Trosko JE, Mansour VH (1969) Platinum compounds: a new class of potent antitumour agents. Nature 222:385–386

    Article  CAS  PubMed  Google Scholar 

  • Sabourin CL, Carpenter JC, Leib TK, Spivack JL (1996) Biodegradation of dimethylsilanediol in soils. Appl Environ Microb 62:4352–4360

    CAS  Google Scholar 

  • Salata OV (2004) Applications of nanoparticles in biology and medicine. J Nanobiotechnol 2:3

    Article  Google Scholar 

  • Sato K, Okazaki T, Imaeda K, Okami Y (1978) New antibiotics, aplasmomycins-B and aplasmomycins-C. J Antibiot 31:632–635

    Article  CAS  PubMed  Google Scholar 

  • Shaw CFI (1999) Gold-based therapeutic agents. Chem Rev 99:2589–2600

    Article  CAS  Google Scholar 

  • Shukla R, Bansal V, Chaudhary M, Basu A, Bhonde RR, Sastry M (2005) Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 21:10644–10654

    Article  CAS  PubMed  Google Scholar 

  • Siddik ZH (2003) Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22:7265–7279

    Article  CAS  PubMed  Google Scholar 

  • Sloth JJ, Larsen EH, Julshamn K (2005) Report on three aliphatic dimethylarsinoyl compounds as common minor constituents in marine samples. An investigation using high-performance liquid chromatography/inductively coupled plasma mass spectrometry and electrospray ionisation tandem mass spectrometry. Rapid Commun Mass Spectrom 19:227–235

    Article  CAS  PubMed  Google Scholar 

  • Sommer M, Kaczorek D, Kuzyakov Y, Breuer J (2006) Silicon pools and fluxes in soils and landscapes—a review. J Plant Nutr Soil Sci 169:310–329

    Article  CAS  Google Scholar 

  • Stout TJ, Clardy J, Pathirana IC, Fenical W (1991) Aplasmomycin-C—structural studies of a marine antibiotic. Tetrahedron 47:3511–3520

    Article  CAS  Google Scholar 

  • Tampa M, Sarbu I, Matei C, Benea V, Georgescu SR (2014) Brief history of syphilis. J Med Life 7:4–10

    PubMed Central  CAS  PubMed  Google Scholar 

  • Tang J (2013) Microbial organic fertilizer prepared using selenium-enriched maggot, selenium-enriched plant waste, selenium-enriched mushroom waste, mineral, vitamin and composite microbial inoculum. CN103664354-A CN10587397 21 Nov 2013

  • Taylor A (1996) Biochemistry of tellurium. Biol Trace Elem Res 55:231–239

    Article  CAS  PubMed  Google Scholar 

  • Thakkar KN, Mhatre SS, Parikh RY (2010) Biological synthesis of metallic nanoparticles. Nanomed Nantotechnol Biol Med 6:257–262

    Article  CAS  Google Scholar 

  • Tiekink ER (2003) Phosphinegold(I) thiolates—pharmacological use and potential. Bioinorg Chem Appl 1:53–67

    Article  PubMed Central  CAS  Google Scholar 

  • Tukai R, Maher WA, McNaught IJ, Ellwood MJ (2002) Measurement of arsenic species in marine macroalgae by microwave-assistedextraction and high performance liquid chromatography–inductively coupled plasma mass spectrometry. Anal Chim Acta 457:173–185

    Article  CAS  Google Scholar 

  • Turel I (2015) Special issue: practical applications of metal complexes. Molecules 20:7951–7956

    Article  CAS  PubMed  Google Scholar 

  • van Hullebusch ED, Yin NH, Seignez N, Labanowski J, Gauthier A, Lens PNL, Avril C, Sivry Y (2015) Bio-alteration of metallurgical wastes by Pseudomonas aeruginosa in a semi flow-through reactor. J Environ Manag 147:297–305

    Article  CAS  Google Scholar 

  • van Rijt SH, Sadler PJ (2009) Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discov Today 14:1089–1097

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Vidal FV, Vidal VMV (1980) Arsenic metabolism in marine-bacteria and yeast. Mar Biol 60:1–7

    Article  CAS  Google Scholar 

  • Wang H-M, Chen C-Y, Chen C-Y, Ho M-L, Chou Y-T, Chang H-C, Lee C-H, Wang C-Z, Chu I-M (2010) (-)-N-formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant. Bioorg Med Chem 18:5241–5247

    Article  CAS  PubMed  Google Scholar 

  • Whanger PD (2002) Selenocompounds in plants and animals and their biological significance. J Am Coll Nutr 21:223–232

    Article  CAS  PubMed  Google Scholar 

  • Wickenheiser EB, Michalke K, Drescher C, Hirner AV, Hensel R (1998) Development and application of liquid and gas-chromatographic speciation techniques with element specific (ICP-MS) detection to the study of anaerobic arsenic metabolism. Fresenius J Anal Chem 362:498–501

    Article  CAS  Google Scholar 

  • Williams KJ (2009) The introduction of ‘chemotherapy’ using arsphenamine—the first magic bullet. J R Soc Med 102:343–348

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Williams PN, Islam MR, Adomako EE, Raab A, Hossain SA, Zhu YG, Feldmann J, Meharg AA (2006) Increase in rice grain arsenic for regions of Bangladesh irrigating paddies with elevated arsenic in groundwaters. Environ Sci Technol 40:4903–4908

    Article  CAS  PubMed  Google Scholar 

  • Winter M (2015) WebElements: the periodic table on the web. https://www.webelements.com. Accessed 31 July 2015

  • Yezhelyev MV, Gao X, Xing Y, Al-Hajj A, Nie S, O’Regan RM (2006) Emerging use of nanoparticles in diagnosis and treatment of breast cancer. Lancet Oncol 7:657–667

    Article  CAS  PubMed  Google Scholar 

  • Yuan C, Lu X, Qin J, Rosen BP, Le Chris X (2008) Volatile arsenic species released from Escherichia Coli expressing the AsIII S-adenosylmethionine methyltransferase gene. Environ Sci Technol 42:3201–3206

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Zhang J, Li T, Yang YL, Liu HG, Wang YZ (2015) Arsenic concentrations and associated health risks in Laccaria mushrooms from Yunnan (SW China). Biol Trace Elem Res 164:261–266

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The authors gratefully acknowledge help from colleagues from the Australia and New Zealand Metabolomics Network (ANZMN) and Proteomics and Metabolomics Victoria (PMV) for useful discussions on the manuscript.

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Dias, D.A., Kouremenos, K.A., Beale, D.J. et al. Metal and metalloid containing natural products and a brief overview of their applications in biology, biotechnology and biomedicine. Biometals 29, 1–13 (2016). https://doi.org/10.1007/s10534-015-9892-2

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