Abstract
Objective: During the last 50 years there have been significant improvements in life expectancy among people with intellectual disability (ID), and so their incidence of age-associated diseases, such as cancer, is rising. The aim of this study was to compare the rate of cancer in people with ID with that found in the general population.
Methods: Information on 9409 individuals registered with the Disability Services Commission of Western Australia was linked to the State Cancer Registry, with 200 cases of cancer detected over 156,729 person-years. Standardised incidence ratios (SIRs) and 95% confidence intervals were calculated for both sexes separately by 5-year age groups for the period 1982–2001. The same procedures were adopted in the estimation of SIRs for specific types of cancers.
Results: The age-standardised incidence of all cancers in people with ID was not significantly different from the general population. However, males with ID were observed to have a significantly increased risk of leukaemia, brain and stomach cancers, and a reduced risk of prostate cancer, while leukaemia, corpus uteri and colorectal cancers were significantly higher in females.
Conclusions: Health practitioners need to be aware that with improvements in life expectancy the incidence of cancer in people with ID is likely to rise. More proactive health promotion campaigns may be needed for people with ID, who are likely to be poor users of screening services and whose symptoms may not be reported until they are in more advanced, less treatable stages of disease.
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References
Wen X (1997)The Definition and Prevalence of Intellectual Disability. Canberra: Australian Institute of Health and Welfare. Report No.:DIS-2.
WHO (2000)Healthy Ageing:Adults with Intellectual Disabilities. Summative Report. Geneva: World Health Organization. Report No.:WHO/MSD/HPS/MDP/00.3
Roeleveld N, Zielhuis GA, Gabreels F (1997)The prevalence of mental retardation:a critical review of recent literature. Dev Med Child Neurol 39: 125–32.
Durkin MS, Hasan ZM, Hasan KZ (1998)Prevalence and correlates of mental retardation among children in Karachi, Pakistan. Am J Epidemiol 147: 281–288.
Hogg J, Northfield J, Turnbull J (2001)Cancer and People with Learning Disabilities:The Evidence from Published Studies and Experiences from Cancer Services. Kidderminster: Bild Publications.
Bittles AH, Petterson BA, Sullivan SG, et al. (2002)The influence of intellectual disability on life expectancy. J Gerontol A Biol Sci Med Sci 57: M470–M472.
Patja K, Iivanainen M, Vesala H, Oksanen H, Ruoppila I (2000) Life expectancy of people with intellectual disability:a 35-year follow-up study. J Intellect Disabil Res 44: 591–599.
Jancar J (1990)Cancer and mental handicap. A further study (1976–85). Br J Psychiatry 156: 531–533.
Satge D, Sommelet D, Geneix A, et al. (1998)A tumor pro le in Down syndrome. Am J Med Genet 78: 207–216.
Hill DA, Gridley G, Cnattingius S, et al. (2003)Mortality and cancer incidence among individuals with Down syndrome. Arch Intern Med 163: 705–711.
Hasle H, Clemmensen IH, Mikkelsen M (2000)Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet 355: 165–169.
Pritchard-Jones K, Renshaw J, King-Underwood L (1994)The Wilms tumour (WT1)gene is mutated in a secondary leukaemia in a WAGR patient. Hum Mol Genet 3: 1633–1637.
Al-Saleem T, Wessner LL, Scheithauer BW, et al. (1998)Malig-nant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex. Cancer 83: 2208–2216.
Reynolds RM, Browning GG, Nawroz I, Campbell IW (2003)Von Recklinghausen's neurofibromatosis:neurofibromatosis type 1. Lancet 361: 1552–1554.
Boultwood J (2001)Ataxia telangiectasia gene mutations in leukaemia and lymphoma. J Clin Pathol 54: 512–516.
Wallace RA, Webb PM, Schluter PJ (2002)Environmental, medical, behavioural and disability factors associated with Helicobacter pylori infection in adults with intellectual disability. J Intellect Disabil Res 46: 51–60.
Duff M, Scheepers M, Cooper M, Hoghton M, Baddeley P (2001) Helicobacter pylori: has the killer escaped from the institution?A possible cause of increased stomach cancer in a population with intellectual disability. J Intellect Disabil Res 45: 219–225.
Patja K, Eero P, Iivanainen M (2001)Cancer incidence among people with intellectual disability. J Intellect Disabil Res 45: 300–307.
Leonard H, Petterson B, Bower C, Sanders R (2003)Prevalence of intellectual disability in Western Australia. Paediatr Perinat Epidemiol 17: 58–67.
Heber R (1959)A manual on terminology and classification in mental retardation. Am J Ment Defic 64: 1–111.
NCCH (1998)The International Statistical Classification of Dis-eases and Related Health Problems, 10th Revision, Australian modi cation (ICD-10-AM), 1st edn. Sydney: National Centre for Classification in Health.
Taeger D (1999–2001)PAMCOMP Version 1.41. Munster: Uni-versity of Munster.
ABS (2001)Population by Age and Sex, Western Australia. Canberra: Australian Bureau of Statistics. Report No.:3235.5.
Cooke LB (1997)Cancer and learning disability. J Intellect Disabil Res 41: 312–316.
Turner S, Moss S (1996)The health needs of adults with learning disabilities and the health of the nation strategy. J Intellect Disabil Res 40: 438–450.
Higginbotham S, Zhang ZF, Lee IM, et al. (2004)Dietary glycemic load and risk of colorectal cancer in the Women's Health Study. J Natl Cancer Inst 96: 229–233.
Sullivan SG, Glasson EJ, Hussain R, et al. (2003)Breast cancer and use of mammography screening services among women with intellectual disabilities. Prev Med 37: 507–512.
Tracy J, Hosken R (1997)The importance of smoking education and preventative health strategies for people with intellectual disability. J Intellect Disabil Res 41: 416–421.
Lennox NG, Beange H, Edwards NS (2000)The health needs of people with intellectual disability. Med J Aust 173: 328–330.
Cowie M, Fletcher J (1998)Breast awareness project for women with a learning disability. Br J Nurs 7: 774–778.
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Sullivan, S.G., Hussain, R., Threlfall, T. et al. The incidence of cancer in people with intellectual disabilities. Cancer Causes Control 15, 1021–1025 (2004). https://doi.org/10.1007/s10552-004-1256-0
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DOI: https://doi.org/10.1007/s10552-004-1256-0