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Neutrophils: important contributors to tumor progression and metastasis

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Abstract

The presence of neutrophils in tumors has traditionally been considered to be indicative of a failed immune response against cancers. However, there is now evidence showing that neutrophils can promote tumor growth, and increasingly, the data support an active role for neutrophils in tumor progression to distant metastasis. Neutrophils have been implicated in promoting metastasis in cancer patients, where neutrophil numbers and neutrophil-related factors and functions have been associated with progressive disease. Nevertheless, the role of neutrophils in tumors, both at the primary and secondary sites, remains controversial, with some studies reporting their anti-tumor functions. This review will focus on the data demonstrating a role for neutrophils in both tumor growth and metastasis and will attempt to clarify the discrepancies in the literature.

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Acknowledgments

The authors wish to acknowledge funding from the National Health and Medical Research Council (NHMRC) of Australia, research fellowships to JAH (NHMRC) and RLA (National Breast Cancer Foundation), and scholarship support to AS (NHMRC) and KAM (Monash University).

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Research Division, Peter MacCallum Cancer Centre, East Melbourne, VIC, 3002, Australia

    Agnieszka Swierczak, Kellie A. Mouchemore & Robin L. Anderson

  2. Arthritis and Inflammation Research Centre, Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Melbourne, Australia

    Agnieszka Swierczak & John A. Hamilton

  3. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

    Kellie A. Mouchemore

  4. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Melbourne, Australia

    Robin L. Anderson

  5. Department of Pathology, The University of Melbourne, Parkville, Melbourne, Australia

    Robin L. Anderson

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  1. Agnieszka Swierczak
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  2. Kellie A. Mouchemore
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  3. John A. Hamilton
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  4. Robin L. Anderson
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Correspondence to Robin L. Anderson.

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John A. Hamilton and Robin L. Anderson joint senior authors

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Swierczak, A., Mouchemore, K.A., Hamilton, J.A. et al. Neutrophils: important contributors to tumor progression and metastasis. Cancer Metastasis Rev 34, 735–751 (2015). https://doi.org/10.1007/s10555-015-9594-9

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