Abstract
Eye and Tissue donation has the capacity to transform lives, yet the vast majority of potential in-hospital donors are not recognised. Studies which describe the relative importance of specific units or wards in determining the size of the donor pool are limited. The aim of this study was to map the distribution of potential Eye and Tissue donors within the study hospital. A 12-month retrospective analysis of all patient deaths at the study hospital was undertaken. The ability to donate corneal, heart valve, bone and skin tissue was investigated. Patients were classified as potential donors if they met specific age criteria and had an absence of contraindications based on electronic database search. There were 985 deaths during the study period. Deaths occurred under the care of 26 separate clinical units, and within 28 unique wards and treatment spaces. Four hundred and forty nine (45.6%) patients were identified as potential eye or tissue donors. The majority of potential donors occurred in ICU, Emergency and palliative care units. Of the subset of 328 deaths ≤ 70 years, the frequency of potential tissue donors was 55% (n = 181). ED and ICU had significantly higher frequencies of potential donor than other wards (86 and 77%, p < 0.01). The current study has identified the ED, ICU and PCUs are being important sites for potential Eye and Tissue Donors within our hospital. These will provide an important focus for future interventions to improve the rate of eye and tissue donation.
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Appendix: ICD contraindications to donation
Appendix: ICD contraindications to donation
Eye tissue contraindications
A81 Atypical virus infections of central nervous system |
B16 Acute hepatitis B |
B17 Other acute viral hepatitis |
B18.0 Chronic viral hepatitis B with delta-agent |
B18.1 Chronic viral hepatitis B without delta-agent |
B18.2 Chronic viral hepatitis C |
B21 Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms |
B22 Human immunodeficiency virus [HIV] disease resulting in other specified diseases |
B23 Human immunodeficiency virus [HIV] disease resulting in other conditions |
B24 Unspecified human immunodeficiency virus [HIV] disease |
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx |
C15-C26 Malignant neoplasms of digestive organs |
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs |
C45-C49 Malignant neoplasms of mesothelial and soft tissue |
C50-C50 Malignant neoplasm of breast |
C51 Malignant neoplasm of vulva |
C51 Malignant neoplasm of vulva |
C52 Malignant neoplasm of vagina |
C52 Malignant neoplasm of vagina |
C54 Malignant neoplasm of corpus uteri |
C55 Malignant neoplasm of uterus, part unspecified |
C56 Malignant neoplasm of ovary |
C57 Malignant neoplasm of other and unspecified female genital organs |
C58 Malignant neoplasm of placenta |
C60-C63 Malignant neoplasms of male genital organs |
C64-C68 Malignant neoplasms of urinary tract |
C69 Malignant neoplasm of eye and adnexa |
C73-C75 Malignant neoplasms of thyroid and other endocrine glands |
C81 Hodgkin lymphoma |
C82 Follicular lymphoma |
C83 Non-follicular lymphoma |
C84 Mature T/NK-cell lymphomas |
C85 Other and unspecified types of non-Hodgkin lymphoma |
C86 Other specified types of T/NK-cell lymphoma |
C88 Malignant immunoproliferative diseases |
C90 Multiple myeloma and malignant plasma cell neoplasms |
C91 Lymphoid leukaemia |
C92 Myeloid leukaemia |
C93 Monocytic leukaemia |
C94 Other leukaemias of specified cell type |
C95 Leukaemia of unspecified cell type |
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue |
G02 Meningitis in other infectious and parasitic diseases classified elsewhere |
G04 Encephalitis, myelitis and encephalomyelitis |
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere |
G10 Huntington disease |
G11 Hereditary ataxia |
G12 Spinal muscular atrophy and related syndromes |
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere |
G14 Postpolio syndrome |
G20 Parkinson disease |
G21 Secondary parkinsonism |
G22 Parkinsonism in diseases classified elsewhere |
G23 Other degenerative diseases of basal ganglia |
G24 Dystonia |
G25 Other extrapyramidal and movement disorders |
G26 Extrapyramidal and movement disorders in diseases classified elsewhere |
G30 Alzheimer disease |
G31 Other degenerative diseases of nervous system, not elsewhere classified |
G32 Other degenerative disorders of nervous system in diseases classified elsewhere |
G35 Multiple sclerosis |
G36 Other acute disseminated demyelination |
G37 Other demyelinating diseases of central nervous system |
H15 Disorders of sclera |
H16 Keratitis |
H17 Corneal scars and opacities |
H18 Other disorders of cornea |
H19 Disorders of sclera and cornea in diseases classified elsewhere |
H20 Iridocyclitis |
H21 Other disorders of iris and ciliary body |
H22 Disorders of iris and ciliary body in diseases classified elsewhere |
Contraindications common to bone, skin and valve donation
A50 Congenital syphilis |
A51 Early syphilis |
A52 Late syphilis |
A53 Other and unspecified syphilis |
A81 Atypical virus infections of central nervous system |
B16 Acute hepatitis B |
B17 Other acute viral hepatitis |
B18.0 Chronic viral hepatitis B with delta-agent |
B18.1 Chronic viral hepatitis B without delta-agent |
B18.2 Chronic viral hepatitis C |
B21 Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms |
B22 Human immunodeficiency virus [HIV] disease resulting in other specified diseases |
B23 Human immunodeficiency virus [HIV] disease resulting in other conditions |
B24 Unspecified human immunodeficiency virus [HIV] disease |
G02 Meningitis in other infectious and parasitic diseases classified elsewhere |
G04 Encephalitis, myelitis and encephalomyelitis |
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere |
G10 Huntington disease |
G11 Hereditary ataxia |
G12 Spinal muscular atrophy and related syndromes |
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere |
G14 Postpolio syndrome |
G20 Parkinson disease |
G21 Secondary parkinsonism |
G22 Parkinsonism in diseases classified elsewhere |
G23 Other degenerative diseases of basal ganglia |
G24 Dystonia |
G25 Other extrapyramidal and movement disorders |
G26 Extrapyramidal and movement disorders in diseases classified elsewhere |
G30 Alzheimer disease |
G31 Other degenerative diseases of nervous system, not elsewhere classified |
G32 Other degenerative disorders of nervous system in diseases classified elsewhere |
G35 Multiple sclerosis |
G36 Other acute disseminated demyelination |
G37 Other demyelinating diseases of central nervous system |
Contraindications specific to bone donation
E10 Type 1 diabetes mellitus |
E24.2 Drug-induced Cushing syndrome |
E27.3 Drug-induced adrenocortical insufficiency |
M80.4 Drug-induced osteoporosis with pathological fracture |
T38.0 Poisoning: Glucocorticoids and synthetic analogues |
Contraindications specific to skin donation
E66 Obesity |
Contraindications specific to valve donation
I05 Rheumatic mitral valve diseases |
I06 Rheumatic aortic valve diseases |
I07 Rheumatic tricuspid valve diseases |
I08 Multiple valve diseases |
I09 Other rheumatic heart diseases |
I33 Acute and subacute endocarditis |
I34 Nonrheumatic mitral valve disorders |
I35 Nonrheumatic aortic valve disorders |
I40 Acute myocarditis |
I41 Myocarditis in diseases classified elsewhere |
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts |
Z95.4 Presence of other heart-valve replacement |
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Dutch, M.J., Denahy, A.F. Distribution of potential eye and tissue donors within an Australian teaching hospital. Cell Tissue Bank 19, 323–331 (2018). https://doi.org/10.1007/s10561-017-9676-8
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DOI: https://doi.org/10.1007/s10561-017-9676-8