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3-Alkynyl selenophene protects against carbon-tetrachloride-induced and 2-nitropropane-induced hepatic damage in rats

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Abstract

The aim of this study was to investigate the protective effect of 3-alkynyl selenophene (3-ASP) on acute liver injury induced by carbon tetrachloride (CCl4) and 2-nitropropane (2-NP) in rats. On the first day of treatment, the animals received 3-ASP (25 mg/kg, p.o.). On the second day, the rats received CCl4 (1 mg/kg, i.p.) or 2-NP (100 mg/kg, p.o.). Twenty-four hours after CCl4 or 2-NP administration, the animals were euthanized, and their plasma and liver were removed for biochemical and histological analyses. The histological analysis revealed extensive injury in the liver of CCl4-exposed and 2-NP-exposed rats, which was attenuated by 3-ASP. 3-ASP significantly attenuated (1) the increase in plasmatic aspartate and alanine aminotransferase activities and lipid peroxidation levels induced by CCl4 and 2-NP; (2) the inhibition of δ-aminolevulinic dehydratase activity caused by 2-NP; and (3) the decrease in ascorbic acid (AA) levels and catalase (CAT) activity caused by CCl4. AA levels and CAT activity remained unaltered in the liver of rats exposed to 2-NP. The protective effect of 3-ASP on acute liver injury induced by CCl4 and 2-NP in rats was demonstrated.

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Acknowledgements

Financial support by FAPERGS, CAPES, and CNPq is gratefully acknowledged. C.W.N. and E.A.W. are recipients of CNPq fellowships.

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  1. Programa de Pós-Graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil

    Ethel Antunes Wilhelm, Cristiano Ricardo Jesse, Marina Prigol, Diego Alves, Ricardo Frederico Schumacher & Cristina Wayne Nogueira

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  1. Ethel Antunes Wilhelm
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  2. Cristiano Ricardo Jesse
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  3. Marina Prigol
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  4. Diego Alves
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  6. Cristina Wayne Nogueira
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Correspondence to Cristina Wayne Nogueira.

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Wilhelm, E.A., Jesse, C.R., Prigol, M. et al. 3-Alkynyl selenophene protects against carbon-tetrachloride-induced and 2-nitropropane-induced hepatic damage in rats. Cell Biol Toxicol 26, 569–577 (2010). https://doi.org/10.1007/s10565-010-9164-4

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