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Synthesis and Antitumor Activities of Resveratrol Derivatives on Cervical Cancer Hela Cells

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Chemistry of Natural Compounds Aims and scope

Using 2-thiophenecarbonyl chloride and 2-furoyl chloride to modify the structure of the natural product resveratrol, we synthesized five novel resveratrol derivatives. The target compounds were evaluated for their antitumor activities against cervical cancer HeLa cells by the MTT method. The results indicated that the compound 3a displayed the best antitumor activities, which is higher than the value of resveratrol, and its inhibition ratio was 95.1% against HeLa cells at the concentration of 75 μmol/L.

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Acknowledgment

This work was financially supported by the Innovation Program of Shanghai Municipal Education Commission (No. 12ZZ188) and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (405ZK110060002).

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Authors and Affiliations

  1. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 201418, Shanghai, P. R. China

    Lu Jin, Yu-Jie Ren & Cheng Du

Authors
  1. Lu Jin
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  2. Yu-Jie Ren
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  3. Cheng Du
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Corresponding author

Correspondence to Yu-Jie Ren.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2015, pp. 563–565.

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Jin, L., Ren, YJ. & Du, C. Synthesis and Antitumor Activities of Resveratrol Derivatives on Cervical Cancer Hela Cells. Chem Nat Compd 51, 652–655 (2015). https://doi.org/10.1007/s10600-015-1377-6

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  • DOI: https://doi.org/10.1007/s10600-015-1377-6

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