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Isolation and Characterization of Hepatoprotective Xanthones from the Fruits of Hovenia acerba

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Chemistry of Natural Compounds Aims and scope

Hovenia acerba Lindl. is not only a delicious fruit but also a traditional Chinese medicine because of its nutritional and medicinal value. A new xanthone, named 1,3-dihydroxy-2-geranyl-4-isoprenyl-5-prenyl-11,12-dimethylpyranoxanthen-10-one (1), and six known xanthones 2–7 were isolated from H. acerba Lindl. for the first time. Compounds 1–7 were assayed for their hepatoprotective activities in HepG2 cells with bicyclol as the positive control. Among them, compounds 1, 3, and 4 showed moderate hepatoprotective activities in improving HepG2 cell survival rates from 52.74 ± 1.37% (APAP, 10 mM) to 73.14 ± 3.31%, 66.26 ± 4.97%, and 61.70 ± 6.43%, respectively.

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Authors and Affiliations

  1. Department of Medical Nursing, Jiyuan Vocational and Technical College, 459000, Jiyuan, Henan, P. R. China

    Xiaogen Ma & Lin Zhang

  2. Emergency Department, Jiyuan People′s Hospital, 459000, Jiyuan, Henan, P. R. China

    Xiaoli Zhang

Authors
  1. Xiaogen Ma
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  2. Lin Zhang
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  3. Xiaoli Zhang
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Correspondence to Xiaogen Ma.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2022, pp. 215–218.

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Ma, X., Zhang, L. & Zhang, X. Isolation and Characterization of Hepatoprotective Xanthones from the Fruits of Hovenia acerba. Chem Nat Compd 58, 245–248 (2022). https://doi.org/10.1007/s10600-022-03651-8

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  • DOI: https://doi.org/10.1007/s10600-022-03651-8

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