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Complete Response to tenalisib and romidepsin with long-term maintenance using tenalisib monotherapy in a patient with relapsed and refractory sézary syndrome

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Summary

Mycosis fungoides (MF) and Sézary Syndrome (SS) are the most common subtypes of cutaneous T cell lymphomas (CTCL). Advanced-stage MF/SS have poor prognoses and may be refractory to multiple systemic treatments. These cases can be difficult to achieve and maintain complete response and there is a need for novel therapeutics. Inhibition of the phosphatidylinositol 3-kinase (PI3K) pathway by Tenalisib presents one such emerging drug. We report a relapsed/refractory SS patient achieving complete remission using the combination of Tenalisib and Romidepsin and subsequently maintaining long-duration CR with Tenalisib monotherapy.

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Acknowledgements

AOH conceptualized the paper. SPI, MD, and AOH participated in patient care. CNN wrote the original manuscript draft. CNN, SPI, MD, PJB, AN, KVR, and AOH reviewed and edited the manuscript.

Funding

This work was supported by Rhizen Pharmaceuticals AG, Basel, Switzerland.

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Authors and Affiliations

  1. Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Christopher N. Nguyen, Madeleine Duvic & Auris O. Huen

  2. Department of Lymphoma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Swaminathan P. Iyer

  3. Rhizen Pharmaceuticals AG, Basel, Switzerland

    Prajak J. Barde, Ajit Nair & Kasi Viswanath Routhu

Authors
  1. Christopher N. Nguyen
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  2. Swaminathan P. Iyer
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  3. Madeleine Duvic
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  4. Prajak J. Barde
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  5. Ajit Nair
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  6. Kasi Viswanath Routhu
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  7. Auris O. Huen
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Correspondence to Christopher N. Nguyen.

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Nguyen, C.N., Iyer, S.P., Duvic, M. et al. Complete Response to tenalisib and romidepsin with long-term maintenance using tenalisib monotherapy in a patient with relapsed and refractory sézary syndrome. Invest New Drugs 41, 350–355 (2023). https://doi.org/10.1007/s10637-022-01315-6

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  • DOI: https://doi.org/10.1007/s10637-022-01315-6

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