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A simple method for simultaneous determination of some organic liquids in in-process materials and effluents produced in the manufacture of amoxicillin and ampicillin

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Abstract

A simple GC method for simultaneous determination of pivaloylchloride, methylacetoacetate, ethylacetoacetate and 2-ethylhexanoic acid in the presence of each other has been developed using glass column packed with 1% Silicone OV-17 on Gaschrom Q 100–120 mesh with temperature programming. Various performance parameters including precision, linearity and limit of detection have been evaluated. The method was found to be suitable for the analysis of these chemicals in in-process materials and effluents associated with the manufacture of amoxicillin and ampicillin. The run time was less than 15 min. The method has been successfully applied to determine the level of these hazardous organic liquids in real time samples.

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References

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  • Material Safety Data Sheet for Ethylacetoacetate (1994). Eastman Chemical Company.

  • Material Safety Data Sheet for Pivaloylchloride (1996). BASF Aktiengesellschaft., version 5.

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  • Material Safety Data Sheet for 2-Ethylhexanoic Acid (1997). BASF Aktiengesellschaft., version 7.

  • Material Safety Data Sheet for Pivaloylchloride, VAV Life Sciences Pvt. Ltd., India, (http://www.vav.in/intermediates13.htm#msds).

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Authors and Affiliations

  1. Department of Chemistry, GC University, Lahore, Pakistan

    Mohammad S Iqbal

  2. Suite # 805 2150 Roche Court, Mississauga, L5K 1T5, ON, Canada

    Muhammad A Akmal

Authors
  1. Mohammad S Iqbal
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  2. Muhammad A Akmal
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Corresponding author

Correspondence to Mohammad S Iqbal.

Additional information

The process details were provided by Dr. Tariq Mahmood the QA & Technical Manager of the plant under study.

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Iqbal, M.S., Akmal, M.A. A simple method for simultaneous determination of some organic liquids in in-process materials and effluents produced in the manufacture of amoxicillin and ampicillin. Environ Monit Assess 151, 397–400 (2009). https://doi.org/10.1007/s10661-008-0281-y

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  • DOI: https://doi.org/10.1007/s10661-008-0281-y

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