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Solubility of Baicalein in Different Solvents from (287 to 323) K

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Abstract

The solubility of baicalein in methanol, ethanol, n-propanol, propan-2-ol, n-butanol, isobutyl alcohol, 1,3-propanediol, and ethyl acetate was measured from (287 to 323) K at atmospheric pressure using high-performance liquid chromatography analysis. Its corresponding (solid + liquid) equilibrium data should provide essential support for the purification of baicalein. The solubility data were correlated by the modified Apelblat equation and the van’t Hoff equation. The solubility data indicated that ethyl acetate might be the best choice for purification of baicalein among these solvents. The correlated results showed that the two equations were both in good agreement with the experimental values, but the correlation of the modified Apelblat equation had smaller deviations than those of the van’t Hoff equation.

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Abbreviations

\(a, b, c\) :

Empirical constants in Eq. 4

\(x\) :

Mole fraction of the solute (\(\hbox {mol}{\cdot }\hbox {mol}^{-1}\))

\(x_\mathrm{cal}, x_\mathrm{exp}\) :

Calculated solubility and experimental values (\(\hbox {mol}{\cdot }\hbox {mol}^{-1}\))

\(\Delta H_\mathrm{f}\) :

Enthalpy of fusion (\(\hbox {kJ}{\cdot }\hbox {mol}^{-1}\))

\(\Delta S_\mathrm{f}\) :

Entropy of fusion of the solute (\(\hbox {J}{\cdot }\hbox {mol}^{-1}{\cdot }\hbox {K} ^{-1}\))

\(\Delta H_\mathrm{s}\) :

Dissolution enthalpy of solute (\(\hbox {kJ}{\cdot }\hbox {mol}^{-1}\))

\(\Delta S_\mathrm{s}\) :

Dissolution entropy of solute (\(\hbox {J} {\cdot } \hbox {mol}^{-1}{\cdot } \hbox {K}^{-1}\))

\(\Delta C_\mathrm{pf}\) :

Difference in the solute heat capacity between the solid and liquid at the melting temperature

\(T\) :

Solution temperature (K)

\(T_\mathrm{f}\) :

Melting temperature of the solute (K)

\(\gamma _\mathrm{c}\) :

Activity coefficient

\(R\) :

Gas constant, 8.314 472 \(\hbox {J} {\cdot } \hbox {mol}^{-1}{\cdot } \hbox {K}^{-1}\)

\(n\) :

Number of experimental points

\(A\) and \(B\) :

Empirical constants in Eqs. 2 and 3

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Acknowledgments

This research was supported by the Natural Science Foundation of Jiangsu Province of China under Grant No. BK20141252.

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Authors and Affiliations

  1. Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, School of Life Science, Huaiying Normal University, Changjiang West Road 111, Huai’an, 223300, Jiangsu, People’s Republic of China

    Jianguo Wu, Liwen Gu, Haining Wang, Lijing Tao & Xinfeng Wang

  2. Jiangsu Key Laboratory for Biomass-based Energy and Enzyme Technology, School of Life Science, Huaiying Normal University, Changjiang West Road 111, Huai’an, 223300, Jiangsu, People’s Republic of China

    Jianguo Wu & Xinfeng Wang

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  1. Jianguo Wu
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  2. Liwen Gu
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  3. Haining Wang
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Correspondence to Jianguo Wu.

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Wu, J., Gu, L., Wang, H. et al. Solubility of Baicalein in Different Solvents from (287 to 323) K. Int J Thermophys 35, 1465–1475 (2014). https://doi.org/10.1007/s10765-014-1740-z

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  • DOI: https://doi.org/10.1007/s10765-014-1740-z

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