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Effect of diquafosol tetrasodium 3% on the conjunctival surface and clinical findings after cataract surgery in patients with dry eye

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Abstract

Purpose

To investigate the effects of diquafosol tetrasodium (DT) 3% on conjunctival impression cytologic findings in addition to clinical symptoms and signs after cataract surgery in patients with preexisting dry eye disease (DED).

Methods

Ninety-four eyes of 94 patients with DED who underwent uneventful cataract surgery were included. In total, 50 patients were treated with DT 3% (group A), while 44 patients were treated with sodium hyaluronate 0.1% (group B) postoperatively, along with topical antibiotics and steroids. Conjunctival impression cytology was performed at baseline and at 4 and 12 weeks after surgery. Visual acuity, ocular surface disease index (OSDI), tear film breakup time (TBUT), keratoepitheliopathy score, Schirmer’s test, and tear clearance rate were measured at baseline and at 1, 4, and 12 weeks, and corneal aberration was analyzed at baseline and at 4 and 12 weeks.

Results

The grade of conjunctival squamous metaplasia was lower at 12 weeks, and goblet cell density was higher at 4 and 12 weeks in group A than in group B (P < 0.05). Compared with group B, group A showed significantly lower OSDI scores at 4 and 12 weeks, longer TBUT at 1, 4, and 12 weeks, lower keratoepitheliopathy scores at 1 and 12 weeks, and lower total root-mean-square score and spherical aberrations at 4 weeks after surgery (P < 0.05).

Conclusions

DT 3% eye drops application after cataract surgery was effective in improving conjunctival epithelial morphology and goblet cell density as well as clinical findings in patients with DED.

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Acknowledgements

This study was partially supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (2017R1A2B4003367) and the Chonnam National University Hospital Biomedical Research Institute (CRI 13906-22 and CRI16020-1).

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Authors and Affiliations

  1. Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea

    Lian Cui, Ying Li, Hyo Seok Lee, Won Choi & Kyung Chul Yoon

  2. Department of Biomedical Sciences and Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, South Korea

    Lian Cui & Kyung Chul Yoon

  3. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea

    Jee Myung Yang

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  1. Lian Cui
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  2. Ying Li
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  3. Hyo Seok Lee
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Correspondence to Kyung Chul Yoon.

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Cui, L., Li, Y., Lee, H.S. et al. Effect of diquafosol tetrasodium 3% on the conjunctival surface and clinical findings after cataract surgery in patients with dry eye. Int Ophthalmol 38, 2021–2030 (2018). https://doi.org/10.1007/s10792-017-0693-1

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  • DOI: https://doi.org/10.1007/s10792-017-0693-1

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