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Preparation and evaluation of binary and ternary inclusion complexes of fenofibrate/hydroxypropyl-β-cyclodextrin

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Abstract

This study aimed to investigate the effect of hydroxypropyl methylcellulose on the complexation of fenofibrate and hydroxypropyl-β-cyclodextrin (HP-β-CD). Initially, phase solubility studies with an excess amount of drug in the HP-β-CD solutions with and without hydroxypropyl methylcellulose (HPMC) were investigated. Both of the binary and ternary complexes were prepared by ball-milling. The complexes were characterized by Fourier transform infrared spectroscopy (FI-IR), X-ray powder diffraction (XPRD), differential scanning calorimetry (DSC) and nuclear magnetic resonance spectroscopy (1H-NMR). The AL type phase-solubility diagram revealed that the complexes of fenofibrate and HP-β-CD were formed with molecular ratio of 1:1. The results of FT-IR, XPRD, DSC and 1H NMR analysis show the formulation of inclusion complexes. In conclusion, the interaction occurrs between fenofibrate and HP-β-CD in the complexes, and the existence of HPMC effectively improves the complexation efficiency and stability constant. The in vitro dissolution test suggests ternary complex is superior to binary complex in terms of the release of fenofibrate.

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Acknowledgements

This work was supported by National Natural Science Foundation of China (No. 21776254).

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Authors and Affiliations

  1. College of Pharmaceutical Sciences, Zhejiang University of Technology, No.18 Chaowang Road, Hangzhou, 310014, China

    Xizhao Ding & Xingyi Zhu

  2. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No.18 Chaowang Road, Hangzhou, 310014, China

    Mengke Zheng, Jiamin Lu & Xingyi Zhu

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  1. Xizhao Ding
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  2. Mengke Zheng
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Correspondence to Xingyi Zhu.

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Ding, X., Zheng, M., Lu, J. et al. Preparation and evaluation of binary and ternary inclusion complexes of fenofibrate/hydroxypropyl-β-cyclodextrin. J Incl Phenom Macrocycl Chem 91, 17–24 (2018). https://doi.org/10.1007/s10847-018-0793-1

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  • DOI: https://doi.org/10.1007/s10847-018-0793-1

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