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Polycaprolactone and poly-β-cyclodextrin polymer blend: a Biopolymers composite film for drug release

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Abstract

Nowadays, biomedical films containing drug carriers are preferred over conventional ones, since the protection of the injury and the therapy is joined within a single device. In the current work, we prepared polycaprolactone (PCL) composite films with β-cyclodextrin (βCD) or its epichlorohydrin crosslinked polymer (βCDP) as ibuprofen (Ibu) drug carrier. The composite films were prepared at different PCL/additive ratios (2, 5, 10 and 20 wt%). ATR-FTIR spectroscopy and water contact angle (WCA) measurements indicated a scarce presence of the additives on the surface. Cross-section scanning electron micrographs showed the presence of aggregates corresponding to βCD and βCDP in the inner regions of the films. The incorporation of βCD and βCDP into the PCL films did not affect their thermal properties as was determined from differential scanning calorimetry (DSC). PCL-films with 10 wt% of the inclusion complexes Ibu@βCD and Ibu@βCDP were prepared and the release studies were performed. At pH = 7.2, PCL-Ibu@βCDP composite film released 55% of Ibu within the first six hours; eight times the amount released by PCL-Ibu@βCD within the same time interval. A plausible mechanism for ibuprofen release is discussed based on the cross-section SEM micrographs of composite films.

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Acknowledgements

The authors acknowledge the support by internal projects of investigation number L19-01 and L217-15 from the Universidad Tecnológica Metropolitana and the program of Magíster en Química mención Tecnología de los Materiales held by the Universidad Tecnológica Metropolitana. Rudy Martin-Trasanco would like to acknowledge the support of the Fondo Nacional de Desarrollo Científico y Tecnológico Grant 11190555.

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Authors and Affiliations

  1. Programa de Magister en Química con mención en Tecnología de los Materiales, Facultad de Ciencias Naturales, Matemática y del Medio Ambiente, Universidad Tecnológica Metropolitana, Av. José Pedro Alessandri 1242, Santiago, Chile

    Francesca Antonella Sepúlveda, Guadalupe del C. Pizarro & Rudy Martin-Trasanco

  2. Grupo Polímeros, Facultad de Química y Biología, Universidad de Santiago de Chile, USACH, Casilla 40, Coreo 33, Santiago, Chile

    Francesca Antonella Sepúlveda & Paula A. Zapata

  3. Universidad de Santiago de Chile (USACH), Facultad de Química y Biología, Departamento de Ciencias del Ambiente, Casilla 40, Coreo 33, Santiago, Chile

    Julio Sánchez

  4. Research Laboratory for Organic Polymers (RLOP), Department of Organic Chemistry, Pontificia Universidad Católica de Chile, 7820436, Macul, Chile

    Fidel E. Rodríguez-González & Alain Tundidor-Camba

  5. Departamento de Ingeniería Mecánica, Universidad de Santiago de Chile, Avda. Lib. Bdo. O’Higgins 3363, 9170002, Santiago, Chile

    Claudio García-Herrera

  6. Departamento de Química y Biología, Facultad de Ciencias Naturales, Universidad de Atacama, Copayapu 485, Copiapó, Chile

    Diego P. Oyarzun

  7. UC Energy Research Center, Pontificia Universidad Católica de Chile, Santiago, Chile

    Alain Tundidor-Camba

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  1. Francesca Antonella Sepúlveda
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  3. Diego P. Oyarzun
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  4. Fidel E. Rodríguez-González
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  8. Guadalupe del C. Pizarro
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  9. Rudy Martin-Trasanco
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Correspondence to Guadalupe del C. Pizarro or Rudy Martin-Trasanco.

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Sepúlveda, F.A., Sánchez, J., Oyarzun, D.P. et al. Polycaprolactone and poly-β-cyclodextrin polymer blend: a Biopolymers composite film for drug release. J Incl Phenom Macrocycl Chem 102, 65–76 (2022). https://doi.org/10.1007/s10847-021-01101-6

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