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Highly porous 45S5 bioglass-derived glass–ceramic scaffolds by gelcasting of foams

  • Ceramics
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Abstract

Several types of alloplastic (artificial) grafts, known as scaffolds, have been developed for the treatment of bone defects caused by trauma and/or infection. Among the materials used to manufacture scaffolds, 45S5 Bioglass is a bioceramic that arouses significant interest due to ease preparation and excellent bioactive response. Among the various processing methods cited in the literature for the production of bioactive glass scaffolds, gelcasting is a method that produces macroporous structures, with interconnected and spherical pores and high mechanical strength. However, in the literature there are few reports about bioactive glass scaffolds produced by gelcasting method. In this work, 45S5-BG scaffolds were produced by gelcasting of foams varying the amount of foaming agent in order to optimize the desirable characteristics of the scaffold. The scaffolds show porosity between 70 and 86% and compressive strength of 1.22 ± 0.7 and 0.78 ± 0.4 MPa. In the biological studies, all 45S5-BG scaffolds showed cytocompatibility towards human osteoblastic cells and bioactive properties using SBF assay.

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Acknowledgements

The authors would like to thank the São Paulo Research Foundation—FAPESP (Grant: 2015/24659-7), the National Council for Scientific and Technological Development (Grant: 456461/2014-0) and the Erasmus Mundus Program (Be Mundus Project) for the financial support. The authors also acknowledge the use of the analytical instrumentation facility at I3S—Instituto de Investigação e Inovação em Saúde (Portugal) and the Brazilian Nanotechnology National Laboratory (LNNano) for X-ray microtomography images.

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Authors and Affiliations

  1. Bioceramics Laboratory (BIOCERAM), Science and Technology Institute - ICT, Universidade Federal de São Paulo – UNIFESP, São José dos Campos, SP, 12231-280, Brazil

    Lilian de Siqueira & Eliandra S. Trichês

  2. Brazilian Nanotechnology National Laboratory (LNNANO), Centro Nacional de Pesquisa em Energia e Materiais – CNPEM, P.O. Box 6192, Campinas, SP, 13083-970, Brazil

    Rubia F. Gouveia

  3. Laboratory for Bone Metabolism and Regeneration, Faculdade de Medicina Dentária, Universidade do Porto - FMDUP, 4200-393, Porto, Portugal

    Liliana Grenho & Maria H. Fernandes

  4. Instituto de Investigação e Inovação em Saúde - i3S, Universidade do Porto - UP, Porto, Portugal

    Fernando J. Monteiro

  5. Instituto de Engenharia Biomédica - INEB, Universidade do Porto - UP, Porto, Portugal

    Fernando J. Monteiro

  6. Departamento de Engenharia Metalúrgica e Materiais, Faculdade de Engenharia, Universidade do Porto, s/n, 4200-465, Porto, Portugal

    Fernando J. Monteiro

  7. Associated Laboratory for Green Chemistry (LAQV/REQUIMTE), University of Porto, 4051-401, Porto, Portugal

    Maria H. Fernandes

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  1. Lilian de Siqueira
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Correspondence to Eliandra S. Trichês.

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de Siqueira, L., Gouveia, R.F., Grenho, L. et al. Highly porous 45S5 bioglass-derived glass–ceramic scaffolds by gelcasting of foams. J Mater Sci 53, 10718–10731 (2018). https://doi.org/10.1007/s10853-018-2337-x

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