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Improvement on biocompatibility and corrosion resistance of a Ti3Zr2Sn3Mo25Nb alloy through surface nanocrystallization and micro-arc oxidation

  • Metals & corrosion
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Abstract

This paper reported a surface modification method to improve corrosion resistance and biocompatibility of a Ti3Zr2Sn3Mo25Nb alloy (named as TLM). A 100-μm-thick layer with an average grain size of 70 nm was created on the alloy surface through sliding friction treatment (SFT), followed by a micro-arc oxidation treatment (MAO) to create a porous coating. Phase composition, morphology, structural characteristics, and elemental characteristics of the MAO coating were inspected by scanning electron microscope (SEM), energy-dispersive spectrometer (EDS) and X-ray photoelectron spectroscopy (XPS). Corrosion resistance of the MAO coating was tested by electrochemical method, and the biocompatibility of the MAO coating was evaluated by cell adhesion and proliferation, and protein adsorption tests. It has found that the surface morphology and chemical composition of the MAO coating produced on the SFT surface (NG-MAO) were not significantly different from those of the MAO coating formed on the original TLM substrate without SFT (CG-MAO). However, the corrosion current density of the NG-MAO coating in 0.9% NaCl solution (PS) and simulated body fluid (SBF) solution decreased 43.4 and 46.7%, respectively, as compared to the CG-MAO coating. The polarization resistance of the NG-MAO coating was also 122% higher than that of the CG-MAO coating in PS. And the protein adsorption capacity and cell proliferation have been significantly increased on the NG-MAO coating compared to its counterpart, the CG-MAO coating.

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References

  1. Geetha M, Singh AK, Asokamani R, Gogia AK (2008) Ti based biomaterials, ultimate choice for orthopedic implants. Prog Mater Sci 54:397–425. https://doi.org/10.1016/j.pmatsci.2008.06.004

    Article  CAS  Google Scholar 

  2. Kaur M, Singh K (2019) Review on titanium and titanium based alloys as biomaterials for orthopaedic applications. Mater Sci Eng C 102:844–862. https://doi.org/10.1016/j.msec.2019.04.064

    Article  CAS  Google Scholar 

  3. Sidhu SS, Singh H, Gepreel MAH (2020) A review on alloy design, biological response, and strengthening of β-titanium alloys as biomaterials. Mater Sci Eng C 121:111661. https://doi.org/10.1016/j.msec.2020.111661

    Article  CAS  Google Scholar 

  4. Fu YB, Chen HN, Guo RQ, Huang YD, Yabo Fu, Mohammad RT (2021) Extraordinary strength-ductility in gradient amorphous structured Zr-based alloy. J Alloys Compd 888:161507. https://doi.org/10.1016/j.jallcom.2021.161507

    Article  CAS  Google Scholar 

  5. Xu XX, Jia ZJ, Zheng YF, Wang YJ (2021) Bioadaptability of biomaterials: Aiming at precision medicine. Matter 4:2648–2650. https://doi.org/10.1016/j.matt.2021.06.033

    Article  CAS  Google Scholar 

  6. Tardelli JDC, Bolfarini C, Dos Reis AC (2020) Comparative analysis of corrosion resistance between beta titanium and Ti-6Al-4V alloys: a systematic review. J Trace Elem Med Biol 62:126618. https://doi.org/10.1016/j.jtemb.2020.126618

    Article  CAS  Google Scholar 

  7. Ibrahim MZ, Sarhan AAD, Yusuf F, Hamdi M (2017) Biomedical materials and techniques to improve the tribological, mechanical and biomedical properties of orthopedic implants-a review article. J Alloys Comps 714:636–667. https://doi.org/10.1016/j.jallcom.2017.04.231

    Article  CAS  Google Scholar 

  8. Pjetursson BE, Thoma D, Jung R, Zwahlen M, Zembic A (2012) A systematic review of the survival and complication rates of implant-supported fixed dental prostheses (FDPs) after a mean observation period of at least 5 years. Clin Oral Implants Res 23:22–38. https://doi.org/10.1111/j.1600-0501.2012.02546.x

    Article  Google Scholar 

  9. Devgan S, Sidhu SS (2019) Evolution of surface modification trends in bone related biomaterials: a review. Mater Chem Phys 233:68–78. https://doi.org/10.1016/j.matchemphys.2019.05.039

    Article  CAS  Google Scholar 

  10. Aglietta M, Iorio Siciliano V, Blasi A, Sculean A, Brägger U, Lang NP, Salvi GE (2012) Clinical and radiographic changes at implants supporting single-unit crowns (SCs) and fixed dental prostheses (FDPs) with one cantilever extension. A retrospective study. Clin Oral Implants Res 23:550–555. https://doi.org/10.1111/j.1600-0501.2011.02391.x

    Article  Google Scholar 

  11. Wysotzki P, Sancho A, Gimsa J, Groll J (2020) A comparative analysis of detachment forces and energies in initial and mature cell-material interaction. Colloids Surf B 190:110894. https://doi.org/10.1016/j.colsurfb.2020.110894

    Article  CAS  Google Scholar 

  12. Yu S, Yu ZT, Wang G, Han JY, Ma X, Dargusch MS (2011) Biocompatibility and osteoconduction of active porous calcium-phosphate films on a novel Ti-3Zr-2Sn-3Mo-25Nb biomedical alloy. Colloids Surf B 85:83–115. https://doi.org/10.1016/j.colsurfb.2011.02.025

    Article  CAS  Google Scholar 

  13. Deng CH, Shen XK, Yang WH, Luo Z, Ma PP, Shen TT, Liu J, Cai KY (2018) Construction of zinc-incorporated nano-network structures on a biomedical titanium surface to enhance bioactivity. Appl Surf Sci 453:263–270. https://doi.org/10.1016/j.apsusc.2018.05.097

    Article  CAS  Google Scholar 

  14. Kurup A, Dhatrak P, Khasnis N (2021) Surface modification techniques of titanium and titanium alloys for biomedical dental applications: a review. Mater Today Proc 39:84–90. https://doi.org/10.1016/j.matpr.2020.06.163

    Article  CAS  Google Scholar 

  15. Zhang LC, Chen LY, Wang LQ (2020) Surface modification of titanium and titanium alloys: technologies, developments, and future interests. Adv Eng Mater 22:2070017. https://doi.org/10.1002/adem.201901258

    Article  CAS  Google Scholar 

  16. Wang YJ (2016) Bioadaptability: an innovative concept for biomaterials. J Mater Sci Technol 32:801–809. https://doi.org/10.1016/j.jmst.2016.08.002

    Article  CAS  Google Scholar 

  17. Yu S, Yu Z, Guo DG, Zhu H, Zhang MH, Han JY, Zhe Yu, Yu ZT et al (2022) Enhanced bioactivity and interfacial bonding strength of Ti3Zr2Sn3Mo25Nb alloy through graded porosity and surface bioactivation. J Mater Sci Technol 100:137–149. https://doi.org/10.1016/j.jmst.2021.06.008

    Article  Google Scholar 

  18. Wang L, Zhou WH, Yu ZT, Yu S, Zhou L, Cao YM, Dargusch M, Wang G (2021) An in vitro evaluation of the hierarchical micro/nanoporous structure of a Ti3Zr2Sn3Mo25Nb Alloy after surface dealloying. ACS Appl Mater Interfaces 13:15017–15030. https://doi.org/10.1021/acsami.1c02140

    Article  CAS  Google Scholar 

  19. Liu XY, Chu PK, Ding CX (2004) Surface modification of titanium, titanium alloys, and related materials for biomedical applications. Mater Sci Eng R Rep 47:49–121. https://doi.org/10.1016/j.mser.2004.11.001

    Article  CAS  Google Scholar 

  20. Song C, Liu M, Deng ZQ, Niu SP, Deng CM, Liao HL (2018) A novel method for in-situ synthesized TiN coatings by plasma spray-physical vapor deposition. Mater Lett 217:127–130. https://doi.org/10.1016/j.matlet.2018.01.068

    Article  CAS  Google Scholar 

  21. Yu S, Guo DG, Han JY, Sun LJ, Zhu H, Yu ZT, Dargusch M, Wang G (2020) Enhancing antibacterial performance and bioactivity of pure titanium by a two-step electrochemical surface coating. ACS Appl Mater Interfaces 12:44433–44446. https://doi.org/10.1021/acsami.0c10032

    Article  CAS  Google Scholar 

  22. Doe Y, Ida H, Seiryu M et al (2020) Titanium surface treatment by calcium modification with acid-etching promotes osteogenic activity and stability of dental implants. Materialia 12:100801. https://doi.org/10.1016/j.mtla.2020.100801

    Article  CAS  Google Scholar 

  23. Cao Y, Dhahad HA, El-Shorbagy MA, Alijani HQ, Zakeri M, Heydari A, Bahonar E, Slouf M et al (2021) Green synthesis of bimetallic ZnO–CuO nanoparticles and their cytotoxicity properties. Sci Rep 11:23479. https://doi.org/10.1038/s41598-021-02937-1

    Article  CAS  Google Scholar 

  24. Hu MR, Wang YF, Yan ZF, Zhao YX, Xia L, Bowen C, Di YB, Zhuang XP (2021) Hierarchical dual-nanonet of polymer nanofibers and supramolecular nanofibrils for air filtration with high filtration efficiency, low air resistance and high moisture permeation. J Mater 24. https://doi.org/10.1039/D1TA01505B

  25. Gu YH, Chen LL, Yue W, Chen P, Chen F, Ning CY (2016) Corrosion behavior and mechanism of MAO coated Ti6Al4V with a grain-fined surface layer. J Alloys Compd 664:770–776. https://doi.org/10.1016/j.jallcom.2015.12.108

    Article  CAS  Google Scholar 

  26. Huo WT, Lin X, Cao HH, Yu S, Yu ZT, Zhang YS (2018) Manipulating the degradation behavior and biocompatibility of Mg alloy through a two-step treatment combining sliding friction treatment and micro-arc oxidation. J Mater Chem B 6:6431–6443. https://doi.org/10.1039/C8TB01072B

    Article  CAS  Google Scholar 

  27. Uvarov V, Popov I (2007) Metrological characterization of X-ray diffraction methods for determination of crystallite size in nano-scale materials. Mater Charact 58:883–891. https://doi.org/10.1016/j.matchar.2006.09.002

    Article  CAS  Google Scholar 

  28. Li XY, Lu L, Li JG, Zhang X, Gao HJ (2020) Mechanical properties and deformation mechanisms of gradient nanostructured metals and alloys. Nat Rev Mater 5:706–723. https://doi.org/10.1038/s41578-020-0212-2

    Article  CAS  Google Scholar 

  29. Zhang YS, Zhang LC, Niu HZ, Bai XF, Yu S, Ma XQ, Yu ZT (2014) Deformation twinning and localized amorphization in nanocrystalline tantalum induced by sliding friction. Mater Lett 127:4–7. https://doi.org/10.1016/j.matlet.2014.04.079

    Article  CAS  Google Scholar 

  30. Liu CQ, Chen XH, Zhang W, Zhang YS, Pan FS (2020) Microstructural evolution in the ultrafine-grained surface layer of Mg-Zn-Y-Ce-Zr alloy processed by sliding friction treatment. Mater Charact 166:110423. https://doi.org/10.1016/j.matchar.2020.110423

    Article  CAS  Google Scholar 

  31. Yu ZT, Yu S, Ma XQ, Cheng J (2017) Development and application of novel biomedical titanium alloy materials. Acta Metall Sin-Engl 53: 1238–64. https://doi.org/10.11900/0412.1961.2017.00288.

  32. Li RY, Wei YJ, Gu L, Qin YG, Li DD (2020) Sol–gel-assisted micro-arc oxidation synthesis and characterization of a hierarchically rough structured Ta–Sr coating for biomaterials. RSC Adv 10:20020–20027. https://doi.org/10.1039/D0RA01079K

    Article  CAS  Google Scholar 

  33. Pesode P, Barve S (2021) Surface modification of titanium and titanium alloy by plasma electrolytic oxidation process for biomedical applications: a review. Mater Today Proc 46:594–602. https://doi.org/10.1016/j.matpr.2020.11.294

    Article  CAS  Google Scholar 

  34. Huang R, Han Y (2013) The effect of SMAT-induced grain refinement and dislocations on the corrosion behavior of Ti-25Nb-3Mo-3Zr-2Sn alloy. Mater Sci Eng C 33:2353–2359. https://doi.org/10.1016/j.msec.2013.01.068

    Article  CAS  Google Scholar 

  35. Gheytani M, Bagheri HR, Masiha HR, Aliofkhazraei M (2014) Effect of SMAT preprocessing on MAO fabricated nanocomposite coating. Surf Eng 30:244–255. https://doi.org/10.1179/1743294414Y.0000000251

    Article  CAS  Google Scholar 

  36. Jin L, Cui WF, Song X, Liu G, Zhou L (2014) Surface nanocrystalline characteristics and corrosion resistance of β-type titanium alloy. Rare Metal Mat Eng 43:80–84

    Article  Google Scholar 

  37. Huang R, Zhuang HY, Han Y (2013) Second-phase-dependent grain refinement in Ti–25Nb–3Mo–3Zr–2Sn alloy and its enhanced osteoblast response. Mater Sci Eng C 35:144–152. https://doi.org/10.1016/j.msec.2013.10.037

    Article  CAS  Google Scholar 

  38. Xu L, Wu C, Lei XC, Zhang K, Liu CC, Ding JN, Shi XL (2018) Effect of oxidation time on cytocompatibility of ultrafine-grained pure Ti in micro-arc oxidation treatment. Surf Coat Technol 342:12–22. https://doi.org/10.1016/j.surfcoat.2018.02.044

    Article  CAS  Google Scholar 

  39. Cao HH, Huo WT, Ma SF, Zhang YS, Zhou L (2018) Microstructure and corrosion behavior of composite, coating on pure Mg acquired by sliding friction, treatment and micro-arc oxidation. Materials 11:1232. https://doi.org/10.3390/ma11071232

    Article  CAS  Google Scholar 

  40. Li GL, Cao HL, Zhang WJ, Ding X, Yang GZ, Qiao YQ, Liu XY, Jiang XQ (2016) Enhanced osseointegration of hierarchical micro/nanotopographic titanium fabricated by microarc oxidation and electrochemical treatment. ACS Appl Mater Interfaces 8:3840–3852. https://doi.org/10.1021/acsami.5b10633

    Article  CAS  Google Scholar 

  41. Zhao QM, Yi L, Jiang LB, Ma YQ, Lin H, Dong J (2019) Surface functionalization of titanium with zinc/strontium-doped titanium dioxide microporous coating via microarc oxidation. Nanomedicine 16:149–161. https://doi.org/10.1016/j.nano.2018.12.006

    Article  CAS  Google Scholar 

  42. Souza JCM, Sordi MB, Kanazawa M, Ravindran S, Henriques B, Silva FS, Aparicio C, Cooper LF (2019) Nano-scale modification of titanium implant surfaces to enhance osseointegration. Acta Biomater 94:112–131. https://doi.org/10.1016/j.actbio.2019.05.045

    Article  CAS  Google Scholar 

  43. Bigerelle M, Anselme K, Noël B, Ruderman I, Hardouin P, Lost A (2002) Improvement in the morphology of Ti-based surfaces: a new process to increase in vitro human osteoblast response. Biomaterials 23:1563–1577. https://doi.org/10.1016/S0142-9612(01)00271-X

    Article  CAS  Google Scholar 

  44. Guo Y, Duan TG, Chen Y, Wen Q (2015) Solvothermal fabrication of three-dimensionally sphere-stacking Sb–SnO2 electrode based on TiO2 nanotube arrays. Ceram 41:8723–8729. https://doi.org/10.1016/j.ceramint.2015.03.092

    Article  CAS  Google Scholar 

  45. Zhu WQ, Shao SY, Xu LN, Chen WQ, Yu XY, Tang KM, Tang ZH, Zhang FM et al (2019) Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment. J Nanobiotechnol 17:55. https://doi.org/10.1186/s12951-019-0488-9

    Article  Google Scholar 

  46. Balusamy T, Jamesh M, Kumar S, Sankara Narayanan TSN (2012) Corrosion resistant Ti alloy for sulphuric acid medium: suitability of Ti–Mo alloys. Werkst Korros 63:9. https://doi.org/10.1002/maco.201106275

    Article  CAS  Google Scholar 

  47. Gheytani M, Aliofkhazraei M, Bagheri HR, Masiha HR, Rouhaghdam AS (2015) Wettability and corrosion of alumina embedded nanocomposite MAO coating on nanocrystalline AZ31B magnesium alloy. J Alloys Compd 649:666–673. https://doi.org/10.1016/j.jallcom.2015.07.139

    Article  CAS  Google Scholar 

  48. Wei GB, Ma PX (2004) Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering. Biomaterials 25:4749–4757. https://doi.org/10.1016/j.biomaterials.2003.12.005

    Article  CAS  Google Scholar 

  49. Mendonça G, Mendonça DBS, Aragão FJL, Cooper LF (2008) Advancing dental implant surface technology: From micro- to nanotopography. Biomaterials 29:3822–3835. https://doi.org/10.1016/j.biomaterials.2008.05.012

    Article  CAS  Google Scholar 

  50. Richert L, Vetrone F, Yi J-H, Zalzal SF, Wuest JD, Rosei F, Nanci A (2008) Surface Nanopatterning to Control Cell Growth. Adv Mater 20:1488–1492. https://doi.org/10.1002/adma.200701428

    Article  CAS  Google Scholar 

  51. Variola F, Vetrone F, Richert L et al (2009) Improving biocompatibility of implantable metals by nanoscale modification of surfaces: an overview of strategies, fabrication methods, and challenges. Small 5:996–1006. https://doi.org/10.1002/smll.200801186

    Article  CAS  Google Scholar 

  52. Andrukhov O, Huber R, Shi B, Berner S, Fan XHR, Moritz A, Spencer ND, Schedle A (2016) Proliferation, behavior, and differentiation of osteoblasts on surfaces of different microroughness. Dent Mater 32:1374–1384. https://doi.org/10.1016/j.dental.2016.08.217

    Article  CAS  Google Scholar 

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Acknowledgements

The authors acknowledge the financial support of the National Natural Science Foundation of China (32071327), National Key Research and Development Program of China (2016YFC1102003), International Science and Technology Cooperation Base of Shaanxi Province (2017GHJD-014) and Science and Technology Program of Shaanxi Province (2019GY-200). And G.W. was grateful for the support from the Queensland Centre for Advanced Materials Processing and Manufacturing (AMPAM) and the ARC Research Hub for Advanced Manufacturing of Medical Devices.

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Authors and Affiliations

  1. State Key Laboratory for Mechanical Behavior of Materials, School of Material Science and Engineering, Xi’an Jiaotong University, Xi’an, 710049, People’s Republic of China

    Sen Yu, Hui Zhu & Dagang Guo

  2. Shaanxi Key Laboratory of Biomedical Metallic Materials, Northwest Institute for Non-Ferrous Metal Research, Xi’an, 710016, People’s Republic of China

    Sen Yu, Depeng Zeng, Wei Zhang, Zhentao Yu & Wangtu Huo

  3. School of Materials Science and Engineering, Northeastern University, Shenyang, 110004, People’s Republic of China

    Depeng Zeng & Lan Wang

  4. Centre of Advanced Materials Processing and Manufacturing (AMPAM), The University of Queensland, St Lucia, QLD, 4072, Australia

    Meili Zhang & Gui Wang

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  1. Sen Yu
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Prime Novelty Statement: This paper reported that a micro-arc oxidation coating was created on a nanograined layer induced by sliding friction treatment on a β-titanium Ti3Zr2Sn3Mo25Nb alloy. The nanocrystalline layer reduced the porosity and increased the thickness of the MAO coating, leading to an enhanced corrosion resistance. The specific porous structure and roughness are favorable for cells to adhere and grow in and enhanced the hydrophilicity to absorb proteins.

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Yu, S., Zeng, D., Zhu, H. et al. Improvement on biocompatibility and corrosion resistance of a Ti3Zr2Sn3Mo25Nb alloy through surface nanocrystallization and micro-arc oxidation. J Mater Sci 57, 5298–5314 (2022). https://doi.org/10.1007/s10853-022-06977-4

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