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Stealth dendrimers for antiarrhythmic quinidine delivery

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Abstract

Dendrimers have been attracting growing attention because of their unique well-defined globular nanoscale architecture and numerous functional groups on the surface. Attachment of PEG to the dendrimer generates stealth dendrimers, which have promising structural advantages for drug delivery. In this study, synthetic methods were explored to deliver antiarrhythmic quinidine by stealth dendrimers. In particular, quinidine was covalently attached to anionic G2.5 and cationic G3.0 polyamidoamine (PAMAM) dendrimers via a glycine spacer, respectively. The resulting quinidine-PAMAM-PEG conjugates were characterized and confirmed by FT-IR and 1H-NMR. In vitro hydrolysis was carried out in pH 7.4 PBS buffer at 37 °C to confirm the bioavailability of the conjugated quinidine.

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Acknowledgments

Hu Yang acknowledges the new faculty startup support from the Department of Biomedical Engineering at Virginia Commonwealth University. This work was supported by Stephanie Lopina’s grants from an NSF CAREER award (BES-9984840), a University of Akron Faculty Research Grant (FRG-1484), and a Sigma Xi Grant-in-Aid of Research.

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Correspondence to Hu Yang.

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Yang, H., Lopina, S.T. Stealth dendrimers for antiarrhythmic quinidine delivery. J Mater Sci: Mater Med 18, 2061–2065 (2007). https://doi.org/10.1007/s10856-007-3144-0

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  • DOI: https://doi.org/10.1007/s10856-007-3144-0

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