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Poly(2-hydroxyethyl methacrylate-co-dodecyl methacrylate-co-acrylic acid): synthesis, physico-chemical characterisation and nafcillin carrier

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Abstract

In the present study polymeric microbeads of poly(2-hydroxyethyl methacrylate-co-dodecyl methacrylate-co-acrylic acid) or p(HEMA-co-dDMA-co-AA) were synthesised and characterized through FT-IR and scanning electron microscopy (SEM); their swelling behavior against saline solution was explored and their in vitro cytotoxicity was evaluated. Further, in order to elucidate kinetic aspects regarding the ternary system p(HEMA-co-dDMA-co-AA), a mathematical model of the reactivity ratios of the comonomers in the terpolymer has been conceived and analyzed. An intensified tendency of AA units accumulation in the copolymer has been noticed, in spite of HEMA units, while dDMA conserves in the copolymer the fraction from the feed. Three compositions have been selected for nafcillin-loading and their in vitro release capacity was evaluated. The compositions of 80:10:10 and 75:10:15 M ratios appear suitable for further in vivo testing, in order to be used as drug delivery systems in the treatment of different osseous diseases.

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Acknowledgments

Professor Georgios Staikos from University of Patras is gratefully acknowledged for his kind support with the elemental analysis. The project PN II IDEAS 729/2009 Polymer biomaterials for bone regeneration. Biomimetism through surface nanostructing is gratefully acknowledged.

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Authors and Affiliations

  1. University Politehnica of Bucharest, 149 Calea Victoriei, 010072, Bucharest, Romania

    Teodora Zecheru, Edina Rusen, Bogdan Mărculescu, Florin Miculescu, Laura Alexandrescu, Iulian Antoniac & Izabela-Cristina Stancu

  2. CBRN Defense and Ecology Scientific Research Center, 225 Şos. Olteniţei, 041309, Bucharest, Romania

    Teodora Zecheru

  3. Military Technical Academy, 81-83 Bd. George Coşbuc, 050141, Bucharest, Romania

    Traian Rotariu

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  1. Teodora Zecheru
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  8. Izabela-Cristina Stancu
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Correspondence to Izabela-Cristina Stancu.

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Zecheru, T., Rotariu, T., Rusen, E. et al. Poly(2-hydroxyethyl methacrylate-co-dodecyl methacrylate-co-acrylic acid): synthesis, physico-chemical characterisation and nafcillin carrier. J Mater Sci: Mater Med 21, 2793–2804 (2010). https://doi.org/10.1007/s10856-010-4129-y

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  • DOI: https://doi.org/10.1007/s10856-010-4129-y

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