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Development of a DNA sensor using a molecular logic gate

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Abstract

This communication reports the increase in fluorescence resonance energy transfer (FRET) efficiency between two laser dyes in the presence of deoxyribonucleic acid (DNA). Two types of molecular logic gates have been designed where DNA acts as input signal and fluorescence intensity of different bands are taken as output signal. Use of these logic gates as a DNA sensor has been demonstrated.

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Acknowledgements

The author SAH is grateful to DST, CSIR, and DAE for financial support to carry out this research work through DST Fast-Track project Ref. No. SE/FTP/PS-54/2007, CSIR project Ref. 03(1146)/09/EMR-II, and DAE Young Scientist Research Award (No. 2009/20/37/8/BRNS/3328).

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Authors and Affiliations

  1. Thin Film and Nanoscience Laboratory, Department of Physics, Tripura University, Suryamaninagar, 799022, Tripura, India

    D. Bhattacharjee, Dibyendu Dey, S. Chakraborty & Syed Arshad Hussain

  2. Department of Botany, Tripura University, Suryamaninagar, 799022, Tripura, India

    S. Sinha

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  1. D. Bhattacharjee
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  2. Dibyendu Dey
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  3. S. Chakraborty
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  4. Syed Arshad Hussain
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  5. S. Sinha
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Correspondence to Syed Arshad Hussain.

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Bhattacharjee, D., Dey, D., Chakraborty, S. et al. Development of a DNA sensor using a molecular logic gate. J Biol Phys 39, 387–394 (2013). https://doi.org/10.1007/s10867-012-9295-3

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  • DOI: https://doi.org/10.1007/s10867-012-9295-3

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