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Neglected N-Truncated Amyloid-β Peptide and Its Mixed Cu–Zn Complexes

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Abstract

Amyloid-β (Aβ) peptides are involved in Alzheimer’s disease (AD) development. The interactions of these peptides with copper and zinc ions also seem to be crucial for this pathology. Although Cu(II) and Zn(II) ions binding by Aβ peptides has been scrupulously investigated, surprisingly, this phenomenon has not been so thoroughly elucidated for N-truncated Aβ4−x—probably the most common version of this biomolecule. This negligence also applies to mixed Cu–Zn complexes. From the structural in silico analysis presented in this work, it appears that there are two possible mixed Cu–Zn(Aβ4−x) complexes with different stoichiometries and, consequently, distinct properties. The Cu–Zn(Aβ4−x) complex with 1:1:1 stoichiometry may have a neuroprotective superoxide dismutase-like activity. On the other hand, another mixed 2:1:2 Cu–Zn(Aβ4−x) complex is perhaps a seed for toxic oligomers. Hence, this work proposes a novel research direction for our better understanding of AD development.

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All data generated or analyzed during this study are included in this published article.

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  1. Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a Street, 02-106, Warsaw, Poland

    Tomasz Frączyk

  2. Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA

    Piotr Cieplak

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TF conceived, designed, performed the literature search and analysis. PC performed in silico analyses of the simulated structures. Both authors wrote the article.

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Frączyk, T., Cieplak, P. Neglected N-Truncated Amyloid-β Peptide and Its Mixed Cu–Zn Complexes. Protein J 41, 361–368 (2022). https://doi.org/10.1007/s10930-022-10056-7

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