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Ureasil–polyether hybrid blend with tuneable hydrophilic/hydrophobic features based on U-PEO1900 and U-PPO400 mixtures

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Abstract

Urea-cross-linked polyether-siloxane hybrid blends with tuneable hydrophilic/hydrophobic features were prepared from a mixture of poly(ethylene oxide) (PEO1900) and poly(propylene oxide) (PPO400), hybridized by end-chain functionalization with (3-isocyanatopropyl)triethoxysilane. The aim of this study was to demonstrate that the combination of the different polyether phases produces materials with hydrophilic and hydrophobic properties. An anti-fog coating and a transparent monolithic swellable hydrogel were produced from the PEO1900 hybrid. Swellability and drug release profiles could be easily tuned by varying the ureasil–PEO/ureasil–PPO ratio in the hybrid matrix. Differential scanning calorimetry (DSC) and small angle X-ray scattering (SAXS) analyses indicated that the nanostructure of the hybrid blends could be described by the existence of a biphasic mixture of PEO1900-rich and PPO400-rich phases, with a fraction of the lamellar domains being derived from the PEO1900 crystallinity. A correlation between the nanoscopic features and the kinetics of the swelling mechanism is proposed, based on the results of in situ SAXS analyses. In vitro monitoring using UV–Vis spectroscopy indicated that the kinetics of drug release from the PEO1900:PPO400 hybrid blends could be controlled by varying the proportions of the hydrophilic (PEO1900) and hydrophobic (PPO400) hybrids. The response to pH change and to application of a magnetic field to the PEO1900-magnetite nanocomposite indicated that the production of stimuli-responsive delivery devices based on ureasil–PE should be feasible in the near future.

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Acknowledgments

Financial support for this work was provided by the Brazilian agencies CAPES, CNPq, and FAPESP, and the French agency COFECUB (Project Number: Ph. 564/07). SOLEIL (France) and LNLS (Brazil) are gratefully acknowledged for technical and financial assistance during the SAXS and XAS measurements. The authors would like to thank Dr. Edesia Martins Barros de Sousa (CDTN–CNEN–Belo Horizonte, MG–Brazil) for the help in the delivery profile measurements under magnetic field.

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Authors and Affiliations

  1. Chemistry Institute, UNESP, Rua Professor Francisco Degni 55, Araraquara, SP, 14800-900, Brazil

    Eduardo F. Molina, Celso R. Nogueira Jesus, Sandra H. Pulcinelli & Celso V. Santilli

  2. Synchrotron SOLEIL L’Orme des Merisiers, BP 48, Saint Aubin, Gif-sur-Yvette, 91192, France

    Eduardo F. Molina & Valérie Briois

  3. Pharmaceutical Sciences School, UNESP, Araraquara-Jaú Interstate Highway, Km 1, Araraquara, SP, Brazil

    Leila A. Chiavacci

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  1. Eduardo F. Molina
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  2. Celso R. Nogueira Jesus
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  3. Leila A. Chiavacci
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  4. Sandra H. Pulcinelli
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  5. Valérie Briois
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  6. Celso V. Santilli
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Correspondence to Celso V. Santilli.

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Molina, E.F., Jesus, C.R.N., Chiavacci, L.A. et al. Ureasil–polyether hybrid blend with tuneable hydrophilic/hydrophobic features based on U-PEO1900 and U-PPO400 mixtures. J Sol-Gel Sci Technol 70, 317–328 (2014). https://doi.org/10.1007/s10971-014-3300-1

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  • DOI: https://doi.org/10.1007/s10971-014-3300-1

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