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Chitosan/(ureasil–PEO hybrid) blend for drug delivery

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Abstract

The effect of chitosan addition on the structure and drug release properties of ureasil–polyethylene oxide (U–PEO) hybrid materials was examined. The hybrids and the blends were prepared by the sol–gel route and their structural features were characterized by infrared spectroscopy, differential scanning calorimetry, X-ray powder diffraction, and small angle X-ray scattering. The different characterization techniques revealed the formation of transparent, rubbery, flexible, water-insoluble, and low crystalline chitosan/(U–PEO hybrid) blends, which could easily dissolve pramoxine (used as a model drug). The results showed that the combined addition of chitosan and pramoxine improved the compatibility of the organic and inorganic components of the U–PEO matrix, and provided a means of tailoring the amount of drug released at steady state equilibrium.

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Acknowledgments

This work received financial support from CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), and FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo).

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Authors and Affiliations

  1. Institute of Chemistry, São Paulo State University (UNESP), Rua Prof. Francisco Degni 55, Araraquara, SP, CEP 14800-900, Brazil

    Mayté Paredes, Sandra H. Pulcinelli, Vanessa Gonçalves & Celso V. Santilli

  2. Center for Technological Applications and Nuclear Development (CEADEN), Calle 30 No. 502 e/5ta y 7ma, Playa, Havana, Cuba

    Mayté Paredes

  3. Center for Biomaterials (BIOMAT), University of Havana, Ave. Universidad y Ronda, s/n, Vedado, Havana, Cuba

    Carlos Peniche

Authors
  1. Mayté Paredes
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  2. Sandra H. Pulcinelli
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  3. Carlos Peniche
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  4. Vanessa Gonçalves
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  5. Celso V. Santilli
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Correspondence to Mayté Paredes.

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Paredes, M., Pulcinelli, S.H., Peniche, C. et al. Chitosan/(ureasil–PEO hybrid) blend for drug delivery. J Sol-Gel Sci Technol 72, 233–238 (2014). https://doi.org/10.1007/s10971-014-3314-8

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  • DOI: https://doi.org/10.1007/s10971-014-3314-8

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