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Thermal stability of new biologic active copper(II) complexes with 5,6-dimethylbenzimidazole

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Abstract

Three new coordinative compounds that contain mixed ligands (5,6-dimethylbenzimidazole and acrylato anion) were synthesized and characterized. The features of complexes have been assigned from microanalytical, IR, UV–Vis and EPR spectra as well as thermal analysis. IR data are in accordance with unidentate nature of 5,6-dimethylbenzimidazole while the acrilato ion acts as uni- or bidentate ligand. The electronic spectra display the characteristic pattern of square pyramidal or octahedral stereochemistry, which were confirmed by the EPR spectra. Antibacterial and antifungal activities of the complexes have been determined in vitro, against various Gram-negative and Gram-positive bacteria and fungi. The tested complexes exhibited different spectra of antimicrobial activity and inhibited the microbial ability to colonize the inert surfaces, acting as potential anti-adherence and biofilm-controlling agents. Thermal decomposition evidenced several well-defined steps as dehydration (complex 2), 5,6-dimethylbenzimidazole molecule release (all complexes) and the acrylate decomposition in carbonate (complex 3). The final residue is in all cases copper (II) oxide.

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Acknowledgements

This paper was supported by the Sectorial Operational Programme Human Resources Development (SOP HRD), financed from the European Social Fund and by the Romanian Government under the contract number SOP HRD/107/1.5/S/82514.

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Authors and Affiliations

  1. Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663, Bucharest, Romania

    Ioana Dorina Vlaicu, Madalina Constand, Rodica Olar, Dana Marinescu & Mihaela Badea

  2. National Institute of Materials Physics, P.O. Box MG-7, 077125, Măgurele-Ilfov, Romania

    Maria Nicoleta Grecu

  3. Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor Str., 060101, Bucharest, Romania

    Veronica Lazar & Mariana Carmen Chifiriuc

Authors
  1. Ioana Dorina Vlaicu
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  2. Madalina Constand
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  3. Rodica Olar
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  4. Dana Marinescu
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  5. Maria Nicoleta Grecu
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  7. Mariana Carmen Chifiriuc
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  8. Mihaela Badea
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Correspondence to Mihaela Badea.

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Vlaicu, I.D., Constand, M., Olar, R. et al. Thermal stability of new biologic active copper(II) complexes with 5,6-dimethylbenzimidazole. J Therm Anal Calorim 113, 1369–1377 (2013). https://doi.org/10.1007/s10973-013-2948-z

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  • DOI: https://doi.org/10.1007/s10973-013-2948-z

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