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Thermal behaviour and characterisation of new biologically active Cu(II) complexes with benzimidazole as main ligand

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Abstract

Four coordination compounds of copper(II) were synthesised and characterised in solid state by elemental analysis, infrared, electronic and EPR spectroscopy, as well as by thermal analysis (TG/DTA). The complexes were formulated on the basis of experimental data as: [Cu(BzIm)2(H2O)]·H2O (1), [Cu2(Acr)4(HBzIm)2] (2), [Cu(Acr)2(HBzIm)2] (3) and [Cu(Acr)2(HBzIm)2(H2O)]·H2O (4). IR data are in accordance with the unidentate nature of benzimidazole, in complexes (2), (3) and (4), and bridge bidentate nature of benzimidazole, in complex (1), while acrylato acts as uni- or bridge/chelate ligand. The electronic spectra display the characteristic pattern of square planar, square pyramidal, or octahedral stereochemistry, also confirmed by EPR spectra. Thermal decomposition evidenced several well-defined steps as dehydration of complexes (1) and (4), benzimidazole molecule releases for all complexes and acrylate decomposition in carbonate for complexes (3) and (4). In all four cases, the final residue after thermal treatment in air flow is copper(II) oxide, formed during the decomposition steps for complexes (3) and (4), and, respectively, after the oxidation of the metallic copper for complexes (1) and (2). Antimicrobial activities of the complexes have been determined by in vitro assays, against various Gram-negative and Gram-positive bacterial and fungal strains. Copper(II) complexes were also evaluated for their cytotoxicity on eukaryotic cells.

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Acknowledgements

I. D. Vlaicu would like to thank to the Sectorial Operational Programme Human Resources Development (SOP HRD), financed from the European Social Fund and by the Romanian Government under the contract number SOP HRD/107/1.5/S/82514.

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Authors and Affiliations

  1. Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663, Bucharest, Romania

    Mihaela Badea, Ioana Dorina Vlaicu, Rodica Olar, Madalina Constand & Dana Marinescu

  2. National Institute of Materials Physics, 105bis Atomistilor Str., Măgurele-Ilfov, POB MG-7, 077125, Bucharest, Romania

    Ioana Dorina Vlaicu & Maria Nicoleta Grecu

  3. Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Ave., Bucharest, Romania

    Coralia Bleotu

  4. Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor Str., 060101, Bucharest, Romania

    Mariana Carmen Chifiriuc, Luminita Marutescu & Veronica Lazar

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  1. Mihaela Badea
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  2. Ioana Dorina Vlaicu
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Correspondence to Ioana Dorina Vlaicu.

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Badea, M., Vlaicu, I.D., Olar, R. et al. Thermal behaviour and characterisation of new biologically active Cu(II) complexes with benzimidazole as main ligand. J Therm Anal Calorim 118, 1119–1133 (2014). https://doi.org/10.1007/s10973-014-3745-z

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