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Insight on thermal behaviour of new complexes of Ni(II), Cu(II) and Zn(II) with a bismacrocyclic ligand developed as biologically active species

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Abstract

A multi-component reaction involving metal ion, amines and formaldehyde has been used for a series of decaaza bismacrocyclic complexes M2L(CH3COO)4·nH2O [(1) M: Ni, n = 2.5; (2) M:Cu, n = 1; (3) M:Zn, n = 10; L:1,3-bis(N,N-1,3,6,9,12-pentaazacyclotridecane)-benzene] preparation. Elemental analyses, ESI-MS, IR, UV–Vis–NIR, NMR and EPR spectra, magnetic susceptibility at room temperature, molar conductivities, as well as thermogravimetric analysis, provided data concerning complexes features. The macrocyclic ligand behaves as bischelate, resulting in either a square planar or an octahedral stereochemistry. The in vitro screening of the antimicrobial activity was performed against both reference and clinical isolates multi-drug-resistant strains. The overall antimicrobial potency of complexes was enhanced in comparison with the free ligand, against both planktonic and biofilm-embedded pathogenic strains. Complexes exhibit no cytotoxicity on the HCT 8 tumour cells. Thermogravimetric curves (TG, DTG and DTA) evidenced in air processes as water elimination, acetate into carbonate transformation as well as oxidative degradation of the bismacrocyclic ligand. The powder X-ray diffraction data indicate MO (M: Ni, Cu, Zn) as final product.

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Acknowledgements

The authors thank for the magnetic measurements to researcher Nicolae Stanică from “Ilie Murgulescu” Physical Chemistry Institute of Romanian Academy.

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Authors and Affiliations

  1. Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., Sector 5, 050663, Bucharest, Romania

    Mihaela Badea, Cristina Bucur, Dana Marinescu & Rodica Olar

  2. Institute for Control of Biological Products and Veterinary Medicines, 39 Dudului Str., Sector 6, Bucharest, Romania

    Cristina Bucur

  3. Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalilor St., Bucharest, Romania

    Mariana Carmen Chifiriuc & Veronica Lazar

  4. Research Institute of the University of Bucharest, Spl. Independentei 91-95, Bucharest, Romania

    Mariana Carmen Chifiriuc & Veronica Lazar

  5. Stefan S Nicolau Institute of Virology, 285 Mihai Bravu Ave., Bucharest, Romania

    Coralia Bleotu

  6. National Institute for Materials Physics, P.O. Box MG-7, Bucharest-Magurele, Romania

    Maria-Nicoleta Grecu

Authors
  1. Mihaela Badea
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  2. Cristina Bucur
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  7. Dana Marinescu
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  8. Rodica Olar
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Correspondence to Rodica Olar.

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Badea, M., Bucur, C., Chifiriuc, M.C. et al. Insight on thermal behaviour of new complexes of Ni(II), Cu(II) and Zn(II) with a bismacrocyclic ligand developed as biologically active species. J Therm Anal Calorim 127, 487–497 (2017). https://doi.org/10.1007/s10973-016-5502-y

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  • DOI: https://doi.org/10.1007/s10973-016-5502-y

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