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Thermal, spectral and biological investigation of new nickel complexes with imidazole derivatives

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Abstract

Four new Ni(II) complexes with acrylate and imidazole (Him) or imidazole derivatives [2-methylimidazole(2-MeIm)/5-methylimidazole(5-MeIm)/2-ethylimidazole(2-EtIm)] as ligands were prepared and characterized. All coordination compounds were characterized by elemental analysis, infrared (FTIR) and ultraviolet-visible-near-infrared (UV-Vis-NIR) spectroscopy, mass spectroscopy, magnetic moments measurements and thermal analysis (TG). The resulted complexes were formulated as follows: [Ni(HIm)2(acr)2] (1), [Ni(2-MeIm)2(acr)2(H2O)]·H2O (2), [Ni(5-MeIm)2(acr)2]·H2O· (3), [Ni(2-EtIm)2(acr)2(H2O)]·H2O (4). On the basis of magnetic moments measurements and on UV–Vis–NIR spectra, for all Ni(II) complexes was proposed an octahedral stereochemistry. Acrylate ions act as bidentate in complexes (1) and (3); meanwhile, in (2) and (4) they behave as bidentate and unidentate. Antimicrobial activity of complexes was investigated on ATCC reference and clinical microbial strains. The MIC (minimum inhibitory concentration) values revealed moderate antimicrobial activity of complex (1) against Enterococcus faecium and of complex (2) against Pseudomonas aeruginosa and Bacillus subtilis.

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Acknowledgements

The authors thank to Mariana Carmen Chifiriuc from Faculty of Biology, University of Bucharest for the help with antimicrobial assay. I.D. Vlaicu acknowledges the financial support to the Sectorial Operational Programme Human Resources Development (SOP HRD), financed from the European Social Fund and by the Romanian Government under the contract number SOP HRD/107/1.5/S/82514. This work was partially supported by University of Bucharest.

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Authors and Affiliations

  1. National Institute of Materials Physics, Atomistilor Str. 405A, POB MG-7, 077125, Măgurele, Ilfov, Romania

    Ioana Dorina Vlaicu

  2. Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663, Bucharest, Romania

    Rodica Olar & Mihaela Badea

  3. Department of Soil Sciences, University of Agronomical Sciences and Veterinary Medicine, 59 Mărăşti Str., 011464, Bucharest, Romania

    Gina Vasile Scăeţeanu

  4. 3S-Pharmacological Consultation and Research GmbH, 1 Koenigsbergerstrasse, 27243, Harpstedt, Germany

    Luigi Silvestro & Martin Maurer

  5. “Ilie Murgulescu” Physical Chemistry Institute, Romanian Academy, 202 Splaiul Independentei, 77208, Bucharest, Romania

    Nicolae Stănică

Authors
  1. Ioana Dorina Vlaicu
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  2. Rodica Olar
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  3. Gina Vasile Scăeţeanu
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  4. Luigi Silvestro
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  5. Martin Maurer
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  6. Nicolae Stănică
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  7. Mihaela Badea
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Correspondence to Mihaela Badea.

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Vlaicu, I.D., Olar, R., Scăeţeanu, G.V. et al. Thermal, spectral and biological investigation of new nickel complexes with imidazole derivatives. J Therm Anal Calorim 134, 503–512 (2018). https://doi.org/10.1007/s10973-018-7133-y

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  • DOI: https://doi.org/10.1007/s10973-018-7133-y

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