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A novel synthesis of highly substituted imidazo[1,5-a]pyrazine derivatives by 3-CR/2-CR sequence

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Abstract

By combining a three-component reaction of 2, 3-diaminomaleonitrile, ketones and isocyanides with a subsequent reaction of 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives obtained from isocyanide-based three-component reaction with various alkyl and aryl isocyanates or isothiocyanates can be assembled a new class of highly substituted imidazo[1,5-a]pyrazine derivatives.

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Authors and Affiliations

  1. Department of Chemistry, Shahid Beheshti University, P. O. Box 19396-4716, Tehran, Iran

    Ahmad Shaabani, Ali Maleki & Hamid Mofakham

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  1. Ahmad Shaabani
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  2. Ali Maleki
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  3. Hamid Mofakham
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Correspondence to Ahmad Shaabani.

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Shaabani, A., Maleki, A. & Mofakham, H. A novel synthesis of highly substituted imidazo[1,5-a]pyrazine derivatives by 3-CR/2-CR sequence. Mol Divers 13, 63–67 (2009). https://doi.org/10.1007/s11030-008-9099-3

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  • DOI: https://doi.org/10.1007/s11030-008-9099-3

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