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Organic synthesis in water: a green protocol for the synthesis of 2-(cyclohexylamino)-3- aryl- indeno[1,2-b]furan-4-ones

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Abstract

Aldehydes, 1,3-indandione and cyclohexylisocyanide undergo smooth coupling-cyclization in water to produce the corresponding 2-(cyclohexylamino)-3-aryl- indeno [1,2-b] furan-4-ones in good yields. Water was used as a solvent to avoid the use of other highly toxic and environmentally unfavorable solvents for this synthesis.

Graphical Abstract

A simple and efficient synthesis of 2-(cyclohexylamino)-3-aryl- indeno[1,2-b]furan-4-ones was achieved via a one-pot three-component reaction of cyclohexylisocyanide, aldehydes, and 1,3-indandione in water for 5 h in good yields. zFX

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Authors and Affiliations

  1. Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran

    Majid M. Heravi, Bita Baghernejad & Hossein A. Oskooie

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  1. Majid M. Heravi
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  2. Bita Baghernejad
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  3. Hossein A. Oskooie
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Correspondence to Majid M. Heravi.

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Heravi, M.M., Baghernejad, B. & Oskooie, H.A. Organic synthesis in water: a green protocol for the synthesis of 2-(cyclohexylamino)-3- aryl- indeno[1,2-b]furan-4-ones. Mol Divers 13, 385–387 (2009). https://doi.org/10.1007/s11030-009-9122-3

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  • DOI: https://doi.org/10.1007/s11030-009-9122-3

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