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A practical and efficient synthesis of bis(indolyl)methanes in water, and synthesis of di-, tri-, and tetra(bis-indolyl)methanes under thermal conditions catalyzed by oxalic acid dihydrate

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Abstract

A simple, clean, and highly efficient green protocol has been developed for synthesis of bis(indolyl), di(bis-indolyl), and tris-indolyl methanes by the reaction of indole with aldehydes and ketones irn the presence of oxalic acid dihydrate [(CO2H)2·2H2O] and N-cetyl-N, N, N-trimethylammonium bromide (CTAB) in water. Also, tri(bis-indolyl) and tetra(bis-indolyl)methanes as new bis(indolyl)methanes were prepared under thermal conditions.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, 65174, Hamadan, Iran

    Ramin Ghorbani-Vaghei, Hojat Veisi, Hassan Keypour & Ahmad Ali Dehghani-Firouzabadi

  2. Department of Chemistry, Faculty of Science, Yazd University, 89195-741, Yazd, Iran

    Ahmad Ali Dehghani-Firouzabadi

Authors
  1. Ramin Ghorbani-Vaghei
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  2. Hojat Veisi
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  3. Hassan Keypour
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  4. Ahmad Ali Dehghani-Firouzabadi
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Correspondence to Ramin Ghorbani-Vaghei.

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Ghorbani-Vaghei, R., Veisi, H., Keypour, H. et al. A practical and efficient synthesis of bis(indolyl)methanes in water, and synthesis of di-, tri-, and tetra(bis-indolyl)methanes under thermal conditions catalyzed by oxalic acid dihydrate. Mol Divers 14, 87–96 (2010). https://doi.org/10.1007/s11030-009-9150-z

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  • DOI: https://doi.org/10.1007/s11030-009-9150-z

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