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A diversity-oriented synthesis of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities via microwave-assisted multi-component reactions

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Abstract

Six new series of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities were synthesized by the three-component reactions of aromatic aldehydes, 5-aminoindazole, and various cyclic 1,3-dicarbonyl compounds under microwave irradiation. This protocol has the valuable features of structural diversity of products, broader substrate scope, operational simplicity, high yields, and short reaction time. Moreover, the structure of compound 88a was confirmed by an X-ray crystallographic analysis and attested to the chemoselectivity of reaction where 1-methyl barbituric acid participated.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, 221116, People’s Republic of China

    Feng Shi, Shan-Shan Wu & Shu-Jiang Tu

  2. Clinical Research Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of China

    Shu Zhang

  3. College of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen, Guangdong, 518060, People’s Republic of China

    Yuan Gao

Authors
  1. Feng Shi
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  2. Shu Zhang
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  3. Shan-Shan Wu
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  4. Yuan Gao
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  5. Shu-Jiang Tu
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Corresponding authors

Correspondence to Yuan Gao or Shu-Jiang Tu.

Additional information

Feng Shi and Shu Zhang contributed equally to the work.

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Shi, F., Zhang, S., Wu, SS. et al. A diversity-oriented synthesis of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities via microwave-assisted multi-component reactions. Mol Divers 15, 497–505 (2011). https://doi.org/10.1007/s11030-010-9272-3

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  • DOI: https://doi.org/10.1007/s11030-010-9272-3

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